Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. A preliminary observation

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author PEDROSO, J. L.
BOR-SENG-SHU, E. FMUSP-HC
BRAGA-NETO, P.
FELICIO, A. C. FMUSP-HC
DUTRA, L. A.
FERRAZ, H. B.
TEIXEIRA, M. J. FMUSP-HC
PRADO, G. F. do
BARSOTTINI, O. G.
dc.date.issued 2012
dc.identifier.citation MOVEMENT DISORDERS, v.27, suppl.1, p.S404-S404, 2012
dc.identifier.issn 0885-3185
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2914
dc.description.abstract Objective: To verify whether the presence and severity of restless legs syndrome (RLS) is correlated with substantia nigra (SN) echogenicity, in Parkinson’s disease (PD) and Machado-Joseph disease (MJD) patients. Background: Hyperechogenicity of the SN is a frequent observation on TCS in PD and MJD patients. Additionally, RLS is a sleep disorder that is also frequently found in both diseases. Autopsy studies have demonstrated increased iron content in hyperechogenic SN. Iron storage is also known to be involved in RLS. Methods: A total of 120 subjects were recruited, divided into five groups: 20 MJD patients with RLS, 17 MJD without RLS, 10 PD patients with RLS, 10 PD without RLS, and 63 healthy subjects. RLS was ascertained based on a clinical face-to-face interview. Severity of RLS was assessed by applying the International RLS Rating Scale. TCS was performed through temporal acoustic bone window on both sides by applying a phased-array ultrasound system e quipped with a 5-1 MHz transducer. Results: Significant differences were seen among groups, with a general continuum in mean TCS echogenicity throughout the SN (Figure 1). Pearson’s test for L and R SN areas of echogenicity versus severity of RLS yielded significant inverse correlations among groups (Rp L-SN 5-0.568; p<0.001 and Rp R-SN 520.545; p< 0.001) (Figure 2). No significant correlations were detected for the presence of RLS and SN echogenicity. Conclusions: The present study confirmed that severity of RLS can be influenced by SN echogenicity in PD and MJD patients. This data allows us to suppose that echogenicity of the SN partially explains pathophysiological aspects of RLS in PD and MJD patients. Fig. 1 (1226). Box plots showing substantia nigra (SN) mean area of echogenicity in patient groups with Parkinson’s disease (PD) without restless legs syndrome (RLS), PD with RLS, Machado-Joseph disease (MJD) without RLS, MJD with RLS, and in healthy control group. *indicates outliers. Fig. 2 (1226). Pearson’s correlation test between severity of Restless Leg Syndrome (RLS) in Parkinson’s disease (PD) and in Machado-Joseph disease (MJD) for left and right SN areas of echogenicity.
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Movement Disorders
dc.rights restrictedAccess
dc.title Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. A preliminary observation
dc.type conferenceObject
dc.rights.holder Copyright WILEY-BLACKWELL
dc.description.conferencedate JUN 17-21, 2012
dc.description.conferencelocal Dublin, IRELAND
dc.description.conferencename 16th International Congress of Parkinson's Disease and Movement Disorders
dc.description.group LIM/26
dc.type.category meeting abstract
dc.type.version publishedVersion
hcfmusp.author BOR-SENG-SHU, E.:HC:ICHC
hcfmusp.author FELICIO, A. C.:FM:
hcfmusp.author TEIXEIRA, M. J.:FM:MNE
hcfmusp.origem.id WOS:000305507703348
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
dc.description.index MEDLINE
hcfmusp.citation.wos 0


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