Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP PORTO, F. H. G. FMUSP-HC
DURAN, Fabio Luis de Souza FMUSP-HC
PINTO, Ana Lucia de Sa FMUSP-HC
BRUCKI, Sonia Maria Dozzi FMUSP-HC 2018
dc.identifier.citation NEUROIMAGE-CLINICAL, v.19, p.616-624, 2018
dc.identifier.issn 2213-1582
dc.description.abstract Aerobic training (AT) is a promising intervention to improve cognitive functioning. However, its modulatory effects on brain networks are not yet entirely understood. Sixty-five subjects with mild cognitive impairment performed a moderate intensity, 24-week AT program. Differences in resting regional brain glucose metabolism (rBGM) with FDG-PET were assessed before and after AT on a voxel-by-voxel basis. Structural equation modeling was used to create latent variables based on regions with significant rBGM changes and to test a hypothetical model about the inter-relationships between these changes. There were significant rBGM reductions in both anterior temporal lobes (ATL), left inferior frontal gyrus, left anterior cingulate cortex, right hippocampus, left meddle frontal gyrus and bilateral caudate nuclei. In contrast, there was an increase in rBGM in the right precuneus and left inferior frontal gyrus. Latent variables reflecting the salience network and ATL were created, while the precuneus represented the default mode network. In the model, salience network rBGM was decreased after AT. In contrast, rBGM in the default mode network increased as a final outcome. This result suggested improved salience network efficacy and increased control over other brain functional networks. The ATL network decreased its rBGM and connected to the salience network and default mode network with positive and negative correlations, respectively. The model fit values reached statistical significance, demonstrating that this model explained the variance in the measured data. In mild cognitive impairment subjects, AT modulated rBGM in salience network and default mode network nodes. Such changes were in the direction of the normally expected resting-state metabolic patterns of these networks.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/18245-4]
· Coordination for the Improvement of Higher Education Personnel (CAPES)/Brazil [99999.003029/2014-00]
dc.language.iso eng
dc.publisher ELSEVIER SCI LTD
dc.relation.ispartof Neuroimage-Clinical
dc.rights openAccess
dc.subject Mild cognitive impairment; Aerobic training; Salience network; Default mode network; FDG-PET; Non-pharmacological interventions; Structural equation modeling
dc.subject.other cerebral-blood-flow; mini-mental-state; alzheimers-disease; functional connectivity; older-adults; physical-activity; brain networks; glucose-metabolism; clinical-trials; youthful memory
dc.title Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment
dc.type article
dc.rights.holder Copyright ELSEVIER SCI LTD LIM/15 LIM/17 LIM/21 LIM/43 LIM/45
dc.identifier.doi 10.1016/j.nicl.2018.05.002
dc.identifier.pmid 29984169
dc.type.category original article
dc.type.version publishedVersion PORTO, F. H. G.:HC:IPQ COUTINHO, Artur Martins:HC:ICESP DURAN, Fabio Luis de Souza:FM: PINTO, Ana Lucia de Sa:HC:ICHC GUALANO, Bruno:FM:MCM BUCHPIGUEL, Carlos Alberto:FM:MDR BUSATTO, Geraldo:FM:MPS NITRINI, Ricardo:FM:MNE BRUCKI, Sonia Maria Dozzi:HC:ICHC WOS:000441936300063 2-s2.0-85047464029 OXFORD ENGLAND
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