https://observatorio.fm.usp.br/handle/OPI/29384
Title: | Use of regional citrate anticoagulation for continuous venovenous hemodialysis in critically ill cancer patients with acute kidney injury |
Authors: | SILVA, Veronica Torres Costa e; CAIRES, Renato Antunes; BEZERRA, Juliana Silva; COSTALONGA, Elerson C.; OLIVEIRA, Ana Paula Leandro; COELHO, Fernanda Oliveira; FUKUSHIMA, Julia T.; SOARES, Cilene Muniz; OIKAWA, Luciane; HAJJAR, Ludhmila Abrahao; BURDMANN, Emmanuel A. |
Citation: | JOURNAL OF CRITICAL CARE, v.47, p.302-309, 2018 |
Abstract: | Purpose: This study aimed to evaluate the safety and efficacy of a regional citrate anticoagulation (RCA) protocol for continuous venovenous hemodialysis (CVVHD) in cancer patients with acute kidney injury (AKI) in the intensive care unit (ICU) setting. Material and methods: One hundred twenty two consecutive ICU cancer patients with AKI treated with citrate-based CVVHD were prospectively evaluated in this prospective observational study. Results: A total of 7198 h of CVVHD therapy (250 filters) were performed. Patients were 613 +/- 15.7 years old, 78% had solid cancer and the main AKI cause was sepsis (50%). The in-hospital mortality was 78.7%. Systemic ionized calcium (SCai) was 435 (4.10-4.60) mg/dL, severe hypocalcemia (SCai <3.6 mg/dL) was observed in 4.3% of procedures and post-filter ionized calcium was 1.60 (1.40-1.80) mg/dL. Median filter pa tency was 24.8 (11-43) hours. Factors related to filter clotting were: no tumor evidence (OR 0.44, C10.18-0.99); genitourinary tumor (OR 1.83, CI 1.18-2.81); platelets number (each 10,000/mm(3)) (OR 1.02, CI 1.00-1.04); International Normatized Ratio (INR) (OR 059, CI 0.41-0.85) and citrate dose (each 10 mL/h) (OR 0.88, CI 0.82-0.95). Conclusion: Filler plenty was relatively short and dotting was associated with active cancer disease, genitourinary tumor, lower citrate dose and lower INR. (C) 2018 Published by Elsevier Inc. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/08 Artigos e Materiais de Revistas Científicas - LIM/12 Artigos e Materiais de Revistas Científicas - LIM/29 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_SILVA_Use_of_regional_citrate_anticoagulation_for_continuous_venovenous_2018.PDF Restricted Access | publishedVersion (English) | 430.35 kB | Adobe PDF | View/Open Request a copy |
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