Evolution in the surgical management of colorectal liver metastases: Propensity score matching analysis (PSM) on the impact of specialized multidisciplinary care across two institutional eras

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art_KRUGER_Evolution_in_the_surgical_management_of_colorectal_liver_2018.PDF (178.25 KB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
Citação
JOURNAL OF SURGICAL ONCOLOGY, v.118, n.1, p.50-60, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and Objectives: Liver metastases are indicators of advanced disease in patients with colorectal cancer. Liver resection offers the best possibility of long-term survival. Surgical strategies have evolved in complexity in order to offer resection to a greater number of patients, requiring specialized multidisciplinary care. The current paper focused on analyzing outcomes of patients treated after the development of a dedicated cancer center in our institution. Methods: Patients operated on for CLM from our databank were paired through propensity score matching (PSM), and the initial experience of surgery for CLM was compared with the treatment performed after specialized multidisciplinary management. The demographic, oncological, and surgical features were analyzed between groups. Results: Overall, 355 hepatectomies were performed in 336 patients. Patients operated on during the second era of had greater use of preoperative chemotherapy (P<0.001) as well as exposure to more effective oxaliplatin-based regimens (P<0.001). Surgical management also changed, with minor (P=0.002) and non-anatomic (P=0.006) resections preferred over major operations. We also noted an increased number of minimally invasive resections (P<0.001). Conclusion: Treatment in a multidisciplinary cancer center led to changes in oncological and surgical management. Perioperative chemotherapy was frequently employed, and surgeons adopted a conservative approach to liver parenchyma.
Palavras-chave
chemotherapy, colorectal cancer, liver metastases, parenchymal sparing
URI
https://observatorio.fm.usp.br/handle/OPI/29453
Referências
  1. Adam R, 2004, ANN SURG, V240, P1052, DOI 10.1097/01.sla.0000145964.08365.01
  2. Adam R, 2004, ANN SURG, V240, P1061, DOI 10.1016/J.RECOT.2013.03.002
  3. Adam R, 2012, ONCOLOGIST, V17, P1225, DOI 10.1634/theoncologist.2012-0121
  4. Adams RB, 2013, HPB, V15, P91, DOI 10.1111/j.1477-2574.2012.00557.x
  5. ADSON MA, 1984, ARCH SURG-CHICAGO, V119, P647
  6. Andreou A, 2011, HPB, V13, P774, DOI 10.1111/j.1477-2574.2011.00370.x
  7. Asiyanbola B, 2008, J GASTROINTEST SURG, V12, P842, DOI 10.1007/s11605-008-0494-y
  8. Bipat S, 2005, RADIOLOGY, V237, P123, DOI 10.1148/radiol.2371042060
  9. Bird NC, 2006, J SURG ONCOL, V94, P68, DOI 10.1002/jso.20558
  10. BISMUTH H, 1982, WORLD J SURG, V6, P10, DOI 10.1007/BF01656369
  11. Brenner H, 2014, LANCET, V383, P1490, DOI 10.1016/S0140-6736(13)61649-9
  12. BRUNSCHWIG A, 1963, CANCER, V16, P277, DOI 10.1002/1097-0142(196303)16:3<277::AID-CNCR2820160302>3.0.CO;2-B
  13. Capussotti L, 2007, ANN SURG ONCOL, V14, P195, DOI 10.1245/s10434-006-9055-3
  14. Cremolini C, 2015, NAT REV CLIN ONCOL, V12, P607, DOI 10.1038/nrclinonc.2015.129
  15. Ribeiro HSD, 2016, ABCD-ARQ BRAS CIR DI, V29, P9, DOI 10.1590/0102-6720201600010003
  16. Dindo D, 2004, ANN SURG, V240, P205, DOI 10.1097/01.sla.0000133083.54934.ae
  17. EKBERG H, 1986, BRIT J SURG, V73, P727, DOI 10.1002/bjs.1800730917
  18. Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
  19. Fong Y, 1999, ANN SURG, V230, P309, DOI 10.1097/00000658-199909000-00004
  20. Fonseca GM, 2018, J SURG ONCOL, P1, DOI 10. 1002/jso. 25017
  21. Frankel TL, 2014, J SURG ONCOL, V109, P2, DOI 10.1002/jso.23371
  22. Hammond JS, 2011, BRIT J SURG, V98, P1188, DOI 10.1002/bjs.7630
  23. Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
  24. Herman P, 2013, ABCD-ARQ BRAS CIR DI, V26, P309, DOI 10.1590/S0102-67202013000400011
  25. Hoff PM, 2001, J CLIN ONCOL, V19, P2282, DOI 10.1200/JCO.2001.19.8.2282
  26. House MG, 2010, J AM COLL SURGEONS, V752, P745
  27. HUGHES KS, 1988, DIS COLON RECTUM, V31, P1, DOI 10.1007/BF02552560
  28. Khan AZ, 2009, J HEPATO-BILIARY-PAN, V16, P137, DOI 10.1007/s00534-008-0016-z
  29. Khatri VP, 2005, J CLIN ONCOL, V23, P8490, DOI 10.1200/JCO.2004.00.6155
  30. Kornprat P, 2007, ARCH SURG-CHICAGO, V142, P1087, DOI 10.1001/archsurg.142.11.1087
  31. Torres OJM, 2016, ABCD-ARQ BRAS CIR DI, V29, P173, DOI 10.1590/0102-6720201600030011
  32. May BJ, 2013, J VASC INTERV RADIOL, V24, P241, DOI 10.1016/j.jvir.2012.10.017
  33. McMillan DC, 2007, SURG ONCOL, V16, P3, DOI 10.1016/j.suronc.2007.04.008
  34. Nordlinger B, 2013, LANCET ONCOL, V14, P1208, DOI 10.1016/S1470-2045(13)70447-9
  35. Pawlik TM, 2008, ONCOLOGIST, V13, P51, DOI 10.1634/theoncologist.2007-0142
  36. PEDEN JC, 1963, CANCER, V16, P1133, DOI 10.1002/1097-0142(196309)16:9<1133::AID-CNCR2820160907>3.0.CO;2-F
  37. Poon RT, 2004, ANN SURG, V240, P698, DOI 10.1097/01.sla.0000141195.66155.0c
  38. Poultsides GA, 2010, HPB, V12, P43, DOI 10.1111/j.1477-2574.2009.00121.x
  39. Reissfelder C, 2014, SURGERY, V155, P245, DOI 10.1016/j.surg.2013.07.022
  40. Snowden Chris, 2015, Anesthesiol Clin, V33, P125, DOI 10.1016/j.anclin.2014.11.008
  41. STANGL R, 1994, LANCET, V343, P1405, DOI 10.1016/S0140-6736(94)92529-1
  42. Thirunavukarasu P, 2016, SURG CLIN N AM, V96, P197, DOI 10.1016/j.suc.2015.11.001
  43. Vauthey JN, 2006, J CLIN ONCOL, V24, P2065, DOI 10.1200/JCO.2005.05.3074
  44. von Elm E, 2007, BRIT MED J, V335, P806
  45. WAGNER JS, 1984, ANN SURG, V199, P502, DOI 10.1097/00000658-198405000-00002
  46. Wicherts DA, 2008, ANN SURG, V248, P994, DOI 10.1097/SLA.0b013e3181907fd9
  47. WILSON SM, 1976, ARCH SURG-CHICAGO, V111, P330

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/02
Artigos e Materiais de Revistas Científicas - LIM/37
Artigos e Materiais de Revistas Científicas - ODS/03