Are women living with HIV prone to osteoporosis in postmenopause? A systematic review

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP CEZARINO, Persio Yvon Adri FMUSP-HC
SIMOES, Ricardo dos Santos FMUSP-HC
dc.identifier.citation REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.64, n.5, p.469-473, 2018
dc.identifier.issn 0104-4230
dc.description.abstract BACKGROUND: Some researchers have suggested that HIV infections can increase the cytokines, which might interfere with the bone metabolism and increase the risk of bone mass loss. However, this issue has yet to be consolidated in postmenopausal women. OBJECTIVE: To analyze studies that evaluated the loss of bone mass through DEXA in women living with HIV. MATERIALS AND METHODS: A systematic review was conducted following the PRISMA guideline. The MEDLINE, EMBASE and Cochrane databases were consulted from January 1987 to March 2017. Studies assessing bone mineral density (BMD) in postmenopausal women living with HIV were included. The secondary outcome was to evaluate the impact of antiretroviral on BMD. RESULTS: Sixty percent of the manuscripts suggested that women living with HIV had more bone loss than women in the control group, mainly in the lumbar spine. Forty percent did not observe any difference between groups. One study reported the influence of antiretroviral drugs on bone mass but did not find any difference between groups. CONCLUSION: Our data suggest that HIV infections may have a negative influence on bone mass loss in women. Further studies on the mechanism of this HIV consequence are necessary to clarify the connection as well as the impact of the antiretroviral action on BMD in postmenopausal women.
dc.language.iso eng
dc.relation.ispartof Revista da Associacao Medica Brasileira
dc.rights openAccess
dc.subject Climacteric; Osteoporosis; HIV; Bone Density
dc.subject.other bone-mineral density; active antiretroviral therapy; infected women; immunodeficiency; prevalence; osteopenia; markers
dc.title Are women living with HIV prone to osteoporosis in postmenopause? A systematic review
dc.type article
dc.rights.holder Copyright ASSOC MEDICA BRASILEIRA LIM/58
dc.identifier.doi 10.1590/1806-9282.64.05.469
dc.identifier.pmid 30304148
dc.type.category review
dc.type.version publishedVersion CEZARINO, Persio Yvon Adri:HU:SCGINEC-62 SIMOES, Ricardo dos Santos:HC:ICHC BARACAT, Edmund Chadat:FM:MOG SOARES JUNIOR, Jose Maria:FM:MOG WOS:000446591800014 2-s2.0-85054883906 SCIELO:S0104-42302018000500469 SAO PAULO BRAZIL
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dc.description.index MEDLINE
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