Mitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC)

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP RILEY, Vivienne
BONILLA, Carolina FMUSP-HC 2018
dc.identifier.citation GENES, v.9, n.8, article ID 395, 31p, 2018
dc.identifier.issn 2073-4425
dc.description.abstract The relationship between mitochondrial DNA (mtDNA) and breast cancer has been frequently examined, particularly in European populations. However, studies reporting associations between mtDNA haplogroups and breast cancer risk have had a few shortcomings including small sample sizes, failure to account for population stratification and performing inadequate statistical tests. In this study we investigated the association of mtDNA haplogroups of European origin with several breast cancer risk factors in mothers and children of the Avon Longitudinal Study of Parents and Children (ALSPAC), a birth cohort that enrolled over 14,000 pregnant women in the Southwest region of the UK. Risk factor data were obtained from questionnaires, clinic visits and blood measurements. Information on over 40 independent breast cancer risk factor-related variables was available for up to 7781 mothers and children with mtDNA haplogroup data in ALSPAC. Linear and logistic regression models adjusted for age, sex and population stratification principal components were evaluated. After correction for multiple testing we found no evidence of association of European mtDNA haplogroups with any of the breast cancer risk factors analysed. Mitochondrial DNA haplogroups are unlikely to underlie susceptibility to breast cancer that occurs via the risk factors examined in this study of a population of European ancestry.
dc.description.sponsorship · UK Medical Research
· Wellcome Trust [102215/2/13/2]
· University of Bristol
· Medical Research Council [MR/K002767/1]
· Cancer Research UK [C18281/A19169]
· MSc/PgDip/PgCert Genomic Medicine program at the University of Exeter
· University of Bristol [G0600705, MC_UU_12013/19),]
· Integrative Cancer Epidemiology Programme - Cancer Research UK program [C18281/A19169]
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Genes
dc.rights openAccess
dc.subject mitochondrial DNA; haplogroups; breast cancer; risk factors; ALSPAC; Europeans
dc.subject.other human mtdna haplogroups; association; testosterone; metaanalysis; childhood; mutations; receptor; insulin; height; repair
dc.title Mitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC)
dc.type article
dc.rights.holder Copyright MDPI LIM/38
dc.identifier.doi 10.3390/genes9080395
dc.identifier.pmid 30071701
dc.type.category original article
dc.type.version publishedVersion BONILLA, Carolina:FM: · RILEY, Vivienne:Univ Exeter, MSc Genom Med Programme, G7,Coll House,St Lukes Campus, Exeter EX2 4TE, Devon, England
· ERZURUMLUOGLU, A. Mesut:Univ Leicester, Dept Hlth Sci, Genet Epidemiol Grp, Leicester LE1 7RH, Leics, England; Univ Bristol, Bristol Med Sch, Populat Hlth Sci, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England
· RODRIGUEZ, Santiago:Univ Bristol, Bristol Med Sch, Populat Hlth Sci, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England WOS:000443615400025 2-s2.0-85051300625 BASEL SWITZERLAND
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