In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ASSONE, Tatiane FMUSP-HC
KANASHIRO, Tatiana M. FMUSP-HC
BALDASSIN, Maira P. M. FMUSP-HC
PAIVA, Arthur FMUSP-HC
HAZIOT, Michel E.
SMID, Jerusa
OLIVEIRA, Augusto Penalva de
FONSECA, Luiz Augusto M. FMUSP-HC
NORRIS, Philip J.
CASSEB, Jorge FMUSP-HC
dc.date.issued 2018
dc.identifier.citation BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.22, n.2, p.106-112, 2018
dc.identifier.issn 1413-8670
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/29733
dc.description.abstract Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood. Objective: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1. Material and methods: From 610 Human T cell Leukemia Virus-infected patients of the Human T cell Leukemia Virus outpatient clinic from Institute of Infectious Diseases ""Emilio Ribas"" in Sao Paulo, 273 agreed to participate: 72 had HAM/TSP (excluded from this analysis) and 201 were asymptomatic, a classification performed during a regular neurological appointment. We selected the subgroup made up only by the 201 asymptomatic subjects to avoid bias by the clinical status as a confounder effect, who had laboratory results of Human T cell Leukemia Virus type 1 proviral load and T-cell proliferation assay in our database. They were further grouped according to their serological status in four categories: 121 Human T cell Leukemia Virus type 1 asymptomatic mono-infected carriers; 32 Human T cell Leukemia Virus type 1/Hepatitis C Virus, 29 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1, and 19 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1/Hepatitis C Virus co-infected patients. Clinical data were obtained from medical records and interviews. DNA Human T cell Leukemia Virus type 1 proviral load (PVL) and T-cell proliferation (LPA) assay were performed for all samples. Results: From a total of 273 subjects with Human T cell Leukemia Virus type 1, 80 presented co-infections: 29 had Human Immunodeficiency Virus type 1, 32 had Hepatitis C Virus, and 19 had Human Immunodeficiency Virus type 1 and Hepatitis C Virus. Comparing the groups based on their serological status, independently of being asymptomatic carriers, we observed a significant increase of PVL (p < 0.001) and LPA (p =0.001). However, when groups were stratified according to their clinical and serological status, there was no significant increase in Human T cell Leukemia Virus type 1 PVL and LPA. Conclusion: No significant increase of basal T-cell proliferation among Human T cell Leukemia Virus type 1 co-infected was observed. This interaction may be implicated in liver damage, worsening the prognosis of co-infected patients or, on the contrary, inducing a higher spontaneous clearance of Hepatitis C Virus infection in Human T cell Leukemia Virus type 1 co-infected patients. (C) 2018 Sociedade Brasileira de Infectologia.
dc.description.sponsorship · CNPq [234058/2014-5]
· FAPESP [2012/23397-0, 2014/22827-7]
dc.language.iso eng
dc.publisher ELSEVIER BRAZIL
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights openAccess
dc.subject HCV; HTLV-1; HIV-1; T-cell proliferation
dc.subject.other lymphotropic virus; htlv-i; disease progression; aids progression; proviral load; viral load; hiv; coinfection; impact; brazil
dc.title In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1
dc.type article
dc.rights.holder Copyright ELSEVIER BRAZIL
dc.description.group LIM/38
dc.description.group LIM/56
dc.identifier.doi 10.1016/j.bjid.2018.02.002
dc.identifier.pmid 29499169
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author ASSONE, Tatiane:IMT:
hcfmusp.author KANASHIRO, Tatiana M.:HC:ICHC
hcfmusp.author BALDASSIN, Maira P. M.:HC:ICHC
hcfmusp.author PAIVA, Arthur:IMT:
hcfmusp.author FONSECA, Luiz Augusto M.:HC:ICHC
hcfmusp.author CASSEB, Jorge:IMT:DVCIENT-83
hcfmusp.author.external · HAZIOT, Michel E.:Inst Doencas Infecciosas Emilio Ribas IIER, Sao Paulo, SP, Brazil
· SMID, Jerusa:Inst Doencas Infecciosas Emilio Ribas IIER, Sao Paulo, SP, Brazil
· OLIVEIRA, Augusto Penalva de:Inst Doencas Infecciosas Emilio Ribas IIER, Sao Paulo, SP, Brazil
· NORRIS, Philip J.:Blood Syst Res Inst, San Francisco, CA USA; Univ Calif San Francisco, San Francisco, CA 94143 USA
hcfmusp.origem.id WOS:000443206900005
hcfmusp.origem.id 2-s2.0-85046167377
hcfmusp.origem.id SCIELO:S1413-86702018000200106
hcfmusp.publisher.city RIO DE JANEIRO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
dc.identifier.eissn 1678-4391
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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