Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy
Carregando...
Citações na Scopus
47
Tipo de produção
article
Data de publicação
2018
Editora
FRONTIERS MEDIA SA
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
CHEVILLARD, Christophe
FRADE, Amanda Farage
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
FRONTIERS IN IMMUNOLOGY, v.9, article ID 2791, 14p, 2018
Resumo
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects over 8 million people worldwide. In spite of a powerful innate and adaptive immune response in acute infection, the parasite evades eradication, leading to a chronic persistent infection with low parasitism. Chronically infected subjects display differential patterns of disease progression. While 30% develop chronic Chagas disease cardiomyopathy (CCC)-a severe inflammatory dilated cardiomyopathy-decades after infection, 60% of the patients remain disease-free, in the asymptomatic/indeterminate (ASY) form, and 10% develop gastrointestinal disease. Infection of genetically deficient mice provided a map of genes relevant for resistance to T. cruzi infection, leading to the identification of multiple genes linked to survival to infection. These include pathogen resistance genes (PRG) needed for intracellular parasite destruction, and genes involved in disease tolerance (protection against tissue damage and acute phase death-DTG). All identified DTGs were found to directly or indirectly inhibit IFN-gamma production or Th1 differentiation. We hypothesize that the absolute need for DTG to control potentially lethal IFN-gamma PRG activity leads to T. cruzi persistence and establishment of chronic infection. IFN-gamma production is higher in CCC than ASY patients, and is the most highly expressed cytokine in CCC hearts. Key DTGs that downmodulate IFN-gamma, like IL-10, and Ebi3/IL27p28, are higher in ASY patients. Polymorphisms in PRG and DTG are associated with differential disease progression. We thus hypothesize that ASY patients are disease tolerant, while an imbalance of DTG and IFN-gamma PRG activity leads to the inflammatory heart damage of CCC.
Palavras-chave
disease tolerance gene, pathogen resistance genes, Tripanosoma cruzi, chagas cardiomyopathy, interferon gamma
Referências
- Abel LCJ, 2001, J AUTOIMMUN, V17, P99, DOI 10.1006/jaut.2001.0523
- Abrahamsohn IA, 1996, EXP PARASITOL, V84, P231, DOI 10.1006/expr.1996.0109
- Aggarwal S, 2003, J BIOL CHEM, V278, P1910, DOI 10.1074/jbc.M207577200
- Machuca MA, 2014, HUM IMMUNOL, V75, P1210, DOI 10.1016/j.humimm.2014.09.023
- Antonio CSE, 2008, MOL IMMUNOL, V45, P3580, DOI 10.1016/j.molimm.2008.05.004
- Arantes RME, 2004, AM J PATHOL, V164, P1361, DOI 10.1016/S0002-9440(10)63222-1
- Aukrust P, 1998, CIRCULATION, V97, P1136, DOI 10.1161/01.CIR.97.12.1136
- Bafica A, 2006, J IMMUNOL, V177, P3515, DOI 10.4049/jimmunol.177.6.3515
- Benatar AF, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0004148
- Beraun Y, 1998, TISSUE ANTIGENS, V52, P81, DOI 10.1111/j.1399-0039.1998.tb03028.x
- Bestetti RB, 1997, INT J CARDIOL, V60, P187, DOI 10.1016/S0167-5273(97)00083-1
- Bohme J, 2016, IMMUNOLOGY, V147, P338, DOI 10.1111/imm.12565
- Bombeiro AL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049022
- Brown DA, 2017, NAT REV CARDIOL, V14, P238, DOI 10.1038/nrcardio.2016.203
- Caetano BC, 2011, J IMMUNOL, V187, P1903, DOI 10.4049/jimmunol.1003911
- Cai CW, 2016, PLOS PATHOG, V12, DOI 10.1371/journal.ppat.1005902
- Calzada JE, 2001, TISSUE ANTIGENS, V58, P154, DOI 10.1034/j.1399-0039.2001.580302.x
- Campos MA, 2004, J IMMUNOL, V172, P1711, DOI 10.4049/jimmunol.172.3.1711
- Cardoso MS, 2016, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00659
- Caruso R, 2014, MUCOSAL IMMUNOL, V7, P1467, DOI 10.1038/mi.2014.35
- Chae HJ, 2006, NITRIC OXIDE-BIOL CH, V14, P189, DOI 10.1016/j.niox.2005.11.008
- Costa GC, 2009, J INFECT DIS, V199, P451, DOI 10.1086/596061
- Couper KN, 2008, J IMMUNOL, V180, P5771, DOI 10.4049/jimmunol.180.9.5771
- Criado L, 2012, CYTOKINE, V57, P398, DOI 10.1016/j.cyto.2011.12.007
- Cummings KL, 2004, INFECT IMMUN, V72, P4081, DOI 10.1128/IAI.72.7.4081-4089.2004
- Cunha-Neto E, 2005, AM J PATHOL, V167, P305, DOI 10.1016/S0002-9440(10)62976-8
- Cura CI, 2012, PARASITOLOGY, V139, P516, DOI 10.1017/S0031182011002186
- Guedes PMD, 2010, PLOS NEGLECT TROP D, V4, DOI 10.1371/journal.pntd.0000604
- Dai B, 2013, CELL PHYSIOL BIOCHEM, V32, P960, DOI 10.1159/000354499
- De Alba-Alvarado M, 2018, ACTA TROP, V178, P134, DOI 10.1016/j.actatropica.2017.11.009
- de Oliveira AP, 2016, INFECT GENET EVOL, V45, P132, DOI 10.1016/j.meegid.2016.08.012
- de Oliveira AP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141847
- Dhiman M, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1004516
- Diehl S, 2002, MOL IMMUNOL, V39, P531, DOI 10.1016/S0161-5890(02)00210-9
- Dinkova-Kostova AT, 2015, FREE RADIC BIOL ME B, V88, P179, DOI 10.1016/J.FREERADBI0MED.2015.04.036
- Drigo SA, 2006, MICROBES INFECT, V8, P598, DOI 10.1016/j.micinf.2005.08.009
- Durand JL, 2009, AM J TROP MED HYG, V80, P782, DOI 10.4269/ajtmh.2009.80.782
- Ehrt S, 2001, J EXP MED, V194, P1123, DOI 10.1084/jem.194.8.1123
- Erdmann H, 2013, IMMUNOBIOLOGY, V218, P910, DOI 10.1016/j.imbio.2012.10.005
- Fernandes MC, 2012, FEMS MICROBIOL REV, V36, P734, DOI 10.1111/j.1574-6976.2012.00333.x
- Fernandez-Mestre MT, 2004, HUM IMMUNOL, V65, P725, DOI 10.1016/j.humimm.2004.05.002
- Florez O, 2011, PARASITE IMMUNOL, V33, P506, DOI 10.1111/j.1365-3024.2011.01314.x
- Florez O, 2012, HUM IMMUNOL, V73, P852, DOI 10.1016/j.humimm.2012.04.005
- Fonseca SG, 2007, SCAND J IMMUNOL, V66, P362, DOI 10.1111/j.1365-3083.2007.01987.x
- Frade AF, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-587
- Gaffen SL, 2014, NAT REV IMMUNOL, V14, P585, DOI 10.1038/nri3707
- Gao WD, 2002, INT J PARASITOL, V32, P167, DOI 10.1016/S0020-7519(01)00322-8
- Gomes JAS, 2005, INFECT IMMUN, V73, P7960, DOI 10.1128/IAI.73.12.7960-7966.2005
- Goncalves VM, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002469
- Gu CF, 2013, CYTOKINE, V64, P477, DOI 10.1016/j.cyto.2013.07.022
- Hamano S, 2003, IMMUNITY, V19, P657, DOI 10.1016/S1074-7613(03)00298-X
- Hardison JL, 2006, INFECT IMMUN, V74, P135, DOI 10.1128/IAI.74.1.135-143.2006
- Harris LD, 2010, BLOOD, V116, P4148, DOI 10.1182/blood-2010-05-283549
- Harris LD, 2010, J VIROL, V84, P7886, DOI 10.1128/JVI.02612-09
- He XB, 2013, PLOS PATHOG, V9, DOI 10.1371/journal.ppat.1003569
- HIGUCHI MD, 1993, VIRCHOWS ARCH A, V423, P157, DOI 10.1007/BF01614765
- Holscher C, 1998, INFECT IMMUN, V66, P1208
- Holscher C, 2000, INFECT IMMUN, V68, P4075, DOI 10.1128/IAI.68.7.4075-4083.2000
- Hunter CA, 1997, J IMMUNOL, V158, P3311
- Jansen AM, 2015, ACTA TROP, V151, P1, DOI 10.1016/j.actatropica.2015.07.018
- KALOVIDOURIS AE, 1993, J RHEUMATOL, V20, P1718
- Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
- Khor CC, 2007, NAT GENET, V39, P523, DOI 10.1038/ng1976
- Koga R, 2006, J IMMUNOL, V177, P7059, DOI 10.4049/jimmunol.177.10.7059
- Koo SJ, 2016, INFECT IMMUN, V84, P3527, DOI 10.1128/IAI.00809-16
- Kovac S, 2015, BBA-GEN SUBJECTS, V1850, P794, DOI 10.1016/j.bbagen.2014.11.021
- Krause CD, 2006, CELL RES, V16, P113, DOI 10.1038/sj.cr.7310015
- Kulkarni MM, 2015, IMMUNOLOGY, V145, P225, DOI 10.1111/imm.12438
- Lee HJ, 2007, J MOL BIOL, V369, P967, DOI 10.1016/j.jmb.2007.03.072
- Levick S, 2014, HEART FAIL REV, V19, P227, DOI 10.1007/s10741-013-9393-8
- Meza SKL, 2014, EXP PARASITOL, V146, P34, DOI 10.1016/j.exppara.2014.08.014
- LUSS H, 1995, J MOL CELL CARDIOL, V27, P2015, DOI 10.1016/0022-2828(95)90023-3
- Machado FS, 2000, CIRCULATION, V102, P3003
- Machado FS, 2005, J INFECT DIS, V191, P627, DOI 10.1086/427515
- MacMurray J, 2014, BRAIN BEHAV IMMUN, V35, P169, DOI 10.1016/j.bbi.2013.09.012
- Magalhaes LMD, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0003816
- Marinho CRF, 2007, SCAND J IMMUNOL, V66, P297, DOI 10.1111/j.1365-3083.2007.01958.x
- Martins GA, 2004, MICROBES INFECT, V6, P1133, DOI 10.1016/j.micinf.2004.07.002
- Martins GA, 1999, INFECT IMMUN, V67, P3864
- Medina TS, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01213
- Michailowsky V, 2004, J IMMUNOL, V173, P463, DOI 10.4049/jimmunol.173.1.463
- Michailowsky V, 2001, AM J PATHOL, V159, P1723, DOI 10.1016/S0002-9440(10)63019-2
- Miyazaki Y, 2010, J IMMUNOL, V185, P1150, DOI 10.4049/jimmunol.0900047
- Muller U, 2001, J IMMUNOL, V167, P3346, DOI 10.4049/jimmunol.167.6.3346
- Munoz-San Martin C, 2018, ACTA TROP, V185, P280, DOI 10.1016/j.actatropica.2018.05.004
- Alvarez MN, 2011, J BIOL CHEM, V286, P6627, DOI 10.1074/jbc.M110.167247
- Nogueira LG, 2014, MEDIAT INFLAMM, DOI 10.1155/2014/914326
- Nogueira LG, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001867
- Oliveira AC, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1000870
- Paiva CN, 2018, PLOS PATHOG, V14, DOI 10.1371/journal.ppat.1006928
- Paiva CN, 2009, J LEUKOCYTE BIOL, V86, P1239, DOI 10.1189/jlb.0309187
- Pall ML, 2013, INT J MOL SCI, V14, P22274, DOI 10.3390/ijms141122274
- Parissis JT, 2002, J INTERF CYTOK RES, V22, P223, DOI 10.1089/107999002753536194
- Patten M, 2001, PFLUG ARCH EUR J PHY, V442, P920
- Perez AR, 2007, BRAIN BEHAV IMMUN, V21, P890, DOI 10.1016/j.bbi.2007.02.004
- Ferreira LRP, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-18080-9
- Ferreira LRP, 2014, WORLD J CARDIOL, V6, P782, DOI 10.4330/wjc.v6.i8.782
- Pissetti CW, 2013, J INTERF CYTOK RES, V33, P130, DOI 10.1089/jir.2012.0024
- Pissetti CW, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0000976
- Poncini CV, 2015, J IMMUNOL, V195, P3311, DOI 10.4049/jimmunol.1403019
- Rakshit S, 2014, BBA-MOL CELL RES, V1843, P2645, DOI 10.1016/j.bbamcr.2014.06.014
- Ramasawmy R, 2006, CLIN INFECT DIS, V43, P305, DOI 10.1086/505395
- Ramasawmy R, 2009, J INFECT DIS, V199, P1838, DOI 10.1086/599212
- Reifenberg K, 2007, AM J PATHOL, V171, P463, DOI 10.2353/ajpath.2007.060906
- REIS DD, 1993, AM J TROP MED HYG, V48, P637, DOI 10.4269/ajtmh.1993.48.637
- Reis MM, 1997, CLIN IMMUNOL IMMUNOP, V83, P165, DOI 10.1006/clin.1997.4335
- Risso MG, 2011, AM J TROP MED HYG, V84, P78, DOI 10.4269/ajtmh.2011.10-0177
- Rocha Rodrigues Denise Bertulucci, 2012, Clin Dev Immunol, V2012, P361730, DOI 10.1155/2012/361730
- Rodrigues Mauricio M., 2012, Journal of Parasitology Research, P507874, DOI 10.1155/2012/507874
- Rodriguez-Perez JM, 2005, IMMUNOL LETT, V98, P97, DOI 10.1016/j.imlet.2004.10.017
- Roy BA, 2000, EVOLUTION, V54, P51, DOI 10.1111/j.0014-3820.2000.tb00007.x
- Sales-Campos H, 2015, ACTA PARASITOL, V60, P435, DOI 10.1515/ap-2015-0060
- Santiago HC, 2005, J IMMUNOL, V175, P8165, DOI 10.4049/jimmunol.175.12.8165
- Savan R, 2009, CYTOKINE GROWTH F R, V20, P115, DOI 10.1016/j.cytogfr.2009.02.006
- Schroder K, 2004, J LEUKOCYTE BIOL, V75, P163, DOI 10.1189/jlb.0603252
- Schroder K, 2007, J LEUKOCYTE BIOL, V81, P1577, DOI 10.1189/jlb.0107036
- Sharma J, 2013, INFECT IMMUN, V81, P2278, DOI 10.1128/IAI.00497-12
- Sieve AN, 2010, EUR J IMMUNOL, V40, P2236, DOI 10.1002/eji.200939759
- Silva GK, 2013, J IMMUNOL, V191, P3373, DOI 10.4049/jimmunol.1203293
- SILVA JS, 1995, INFECT IMMUN, V63, P4862
- Silva MC, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03986-3
- Silva RR, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118600
- Soares MP, 2014, TRENDS IMMUNOL, V35, P483, DOI 10.1016/j.it.2014.08.001
- Sousa GR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172833
- Stahl P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110512
- STEIN RW, 1989, MOL CELL BIOL, V9, P4531, DOI 10.1128/MCB.9.10.4531
- Talvani A, 2004, CLIN INFECT DIS, V38, P943, DOI 10.1086/381892
- Talvani A, 2003, MICROBES INFECT, V5, P789, DOI 10.1016/S1286-4579(03)00146-1
- Tarleton RL, 2000, J IMMUNOL, V165, P1520, DOI 10.4049/jimmunol.165.3.1520
- Teixeira MMG, 2006, TROP MED INT HEALTH, V11, P294, DOI 10.1111/j.1365-3156.2006.01575.x
- Teixeira PC, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0001205
- Torres OA, 2010, INFECT GENET EVOL, V10, P682, DOI 10.1016/j.meegid.2010.03.009
- Torzewski M, 2012, AM J PATHOL, V180, P73, DOI 10.1016/j.ajpath.2011.09.006
- Boari JT, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002658
- Van Linthout Sophie, 2017, Curr Heart Fail Rep, V14, P251, DOI 10.1007/s11897-017-0337-9
- VESPA GNR, 1994, INFECT IMMUN, V62, P5177
- Vila-del Sol V, 2008, J IMMUNOL, V181, P4461, DOI 10.4049/jimmunol.181.7.4461
- Vilar-Pereira G, 2016, PLOS PATHOG, V12, DOI 10.1371/journal.ppat.1005947
- Wan XX, 2016, PLOS PATHOG, V12, DOI 10.1371/journal.ppat.1005954
- Wan XX, 2012, J AM HEART ASSOC, V1, DOI 10.1161/JAHA.112.003855
- Wang DC, 1996, LAB INVEST, V75, P809
- Wang ZY, 2002, BIOCHEM PHARMACOL, V63, P1197, DOI 10.1016/S0006-2952(02)00853-5
- Weitzel T, 2012, AM J TROP MED HYG, V86, P229, DOI 10.4269/ajtmh.2012.11-0539
- Wen JJ, 2017, ANTIOXID REDOX SIGN, V27, P550, DOI 10.1089/ars.2016.6831
- West AP, 2011, NAT REV IMMUNOL, V11, P389, DOI 10.1038/nri2975
- Wu AJ, 1997, J CELL PHYSIOL, V171, P117, DOI 10.1002/(SICI)1097-4652(199705)171:2<117::AID-JCP1>3.0.CO;2-R
- Wu YZ, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.191031
- Zafra G, 2007, MICROBES INFECT, V9, P1049, DOI 10.1016/j.micinf.2007.04.010
- ZICKER F, 1990, AM J TROP MED HYG, V43, P498, DOI 10.4269/ajtmh.1990.43.498
- Zorova LD, 2018, ANAL BIOCHEM, V552, P50, DOI 10.1016/j.ab.2017.07.009
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/49