Comesis in patients with breast neoplasia submitted to the hypofractionated radiotherapy with of intensity-modulated beam

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MIRANDA, Fabiana Accioli
VIEIRA, Marina Tamm Lannes
MORAES, Fabio Ynoe de
MARTA, Gustavo Nader FMUSP-HC
CARVALHO, Heloisa de Andrade FMUSP-HC
HANNA, Samir Abdallah
dc.date.issued 2018
dc.identifier.citation REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.64, n.11, p.1023-1030, 2018
dc.identifier.issn 0104-4230
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/29893
dc.description.abstract OBJECTIVE: To assess the cosmetic satisfaction of patients diagnosed with breast cancer submitted to the hypofractionated radiotherapy with IMRT (hIMRT) technique and its correlation with dosimetric data of the radiotherapy planning. MATERIALS AND METHODS: The retrospective cohort study that assessed women with a diagnosis of malignant breast neoplasia submitted to the conservative treatment or radical mastectomy and treated with hIMRT. In the period between August 2007 to December 2014, in a philanthropic/private institution, 170 records were selected. The cosmetic assessment was corned out by means of the Harvard/RTOG/NSABP scale with one-year minimum range after treatment. The collected dosimetric data were: breast/chest wall volume, volume that received 95% (V95%) and 107% (V107%) of the prescribed dose. RESULTS: The volume of the treated breasts ranged from 169 to 2.103 ml (median = 702; IQR: 535 to 914 ml). Median V95% was 86.7% (54.6-96.6%; IQR: 80.0% to 90.6%); eight (5.7%) patients had V95% higher than 95%. Median V107% was 0% (0%-16.3%; IQR: 0.0% to 0.3% and 13); 9.3% patients had V107% higher than 2%. One hundred and thirty-three (78.2%) patients responded to the cosmetic assessment: 99 (74.4%) considered the cosmetic results excellent. Significant associations between cosmetic assessment and breast volume (p=0.875), V95% (p=0.294) e V107% (p=0.301) were not found. CONCLUSION: The cosmetic results showed favorable when using hIMRT, and the lack of correlation with usual the dosimetric data illustrates the capacity of hIMRT to minimize the heterogeneity of the dose in this endpoint, even in voluminous breasts.
dc.language.iso eng
dc.publisher ASSOC MEDICA BRASILEIRA
dc.relation.ispartof Revista da Associacao Medica Brasileira
dc.rights openAccess
dc.subject Hypofractionation; Breast neoplasia; Radiotherapy
dc.subject.other radiation-therapy; randomized-trial; dose-response; cancer; irradiation; fractionation; standard; women; size; rtog
dc.title Comesis in patients with breast neoplasia submitted to the hypofractionated radiotherapy with of intensity-modulated beam
dc.type article
dc.rights.holder Copyright ASSOC MEDICA BRASILEIRA
dc.identifier.doi 10.1590/1806-9282.64.11.1023
dc.identifier.pmid 30570055
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MARTA, Gustavo Nader:HC:ICESP
hcfmusp.author CARVALHO, Heloisa de Andrade:FM:MDR
hcfmusp.author.external · MIRANDA, Fabiana Accioli:Hosp Sirio Libanes SP, Radiote, Sao Paulo, SP, Brazil
· VIEIRA, Marina Tamm Lannes:COI Clin Oncol Integradas RJ, Rio De Janeiro, RJ, Brazil
· MORAES, Fabio Ynoe de:Univ Toronto, Radiat Med Program, Princess Margaret Hosp, Toronto, ON, Canada
· HANNA, Samir Abdallah:Hosp Sirio Libanes SP, Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000453021400012
hcfmusp.origem.id 2-s2.0-85058864530
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 3
hcfmusp.citation.wos 3
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Canadá


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