Increased hyaluroman syntehase-2 expression has impact in the idiopathic pulmonary fibrosis progression
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2012
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WILEY-BLACKWELL
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HISTOPATHOLOGY, v.61, suppl.1, Special Issue, p.207-208, 2012
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Introduction: Idiopathic pulmonary fibrosis (IPF) is a terminal illness characterized by unremitting extracellular matrix (ECM) deposition in the lung. Myofibroblasts and ECM components such as collagen and hyaluronan (HA) have an important role in fibrosis. The expression of HAS1 (HA synthase 1), HAS2, HAS3 and hyaluronic acid receptor (CD44) by epithelial and myofibroblastic cells in patients with IPF were analyzed and correlated with survival. Materials and Methods: Epithelial and myofibroblastic expression of HAS1, HAS2, HAS3 and CD44 were evaluated in 27 surgical lung biopsies from patients with IPF in minimal and severe fibrosis by the point-counting technique. The impact of these markers was tested by pulmonary functional tests and follow-up until IPF related death. Results: HAS2 and CD44 expression were significantly increased and directly associated with severe fibrosis. Myofibroblastic HAS2 activity was indirectly associated to DLO/VA (r=) 0.584; P = 0.05). Kaplan Maier curves determined a higher risk of death for patient with high HAS2 (>6.83%) expression than in low expression (Log Rank P = 0.05). Conclusion: Increased HAS2 activity in epithelial and myofibroblastic cells have an impact in the remodeling process as well as survival evolution, suggesting that strategies aimed at preventing the effect of this ECM component may have a greater impact in patient’s outcome.