Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus
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Citações na Scopus
9
Tipo de produção
article
Data de publicação
2018
Editora
MDPI
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Título da Revista
ISSN da Revista
Título do Volume
Autores
COSTA, Antonio Charlys da
LUCHS, Adriana
MILAGRES, Flavio Augusto de Padua
KOMNINAKIS, Shirley Vasconcelos
GILL, Danielle Elise
LOBATO, Marcia Cristina Alves Brito Sayao
BRUSTULIN, Rafael
CHAGAS, Rogerio Togisaki das
ABRAO, Maria de Fatima Neves dos Santos
SOARES, Cassia Vitoria de Deus Alves
Autor de Grupo de pesquisa
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Organizadores
Citação
VIRUSES-BASEL, v.10, n.10, article ID 520, 12p, 2018
Resumo
Here we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus genomes showed that the breakpoint found in the Brazilian strain (SAFV-BR-193) is indeed a recombination hotspot. Notably, this hotspot is located just one nucleotide after the ribosomal frameshift GGUUUUU motif in the SAFV genome. Empirical studies will be necessary to determine if this motif also affects the binding affinity of RNA-dependent RNA-polymerase (RdRp) and therefore increases the changes of RdRp swap between molecules during the synthesis of viral genomes.
Palavras-chave
saffold virus, cardiovirus, virome, picornavirus, ribosomal frameshifting, GGUUUUU motif, RNA-dependent RNA-polymerase
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