Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes

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art_GRATIVVOL_Updates_in_the_Diagnosis_and_Treatment_of_Paraneoplastic_2018.PDF (469.99 KB)
Citações na Scopus
59
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
Citação
CURRENT ONCOLOGY REPORTS, v.20, n.11, article ID 92, 11p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.
Palavras-chave
Limbic encephalitis, Onconeuronal antibodies, Paraneoplastic neurological syndromes, Paraneoplastic encephalomyelitis, Paraneoplastic cerebellar degeneration, Autoimmune encephalitis, Stiff person syndrome, Progressive encephalomyelitis with rigidity and myoclonus, Opsoclonus-myoclonus syndrome, Morvan syndrome, Ophelia syndrome, N-methyl-d-aspartate receptor (NMDAR) encephalitis, Anti-AMPA receptor (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) encephalitis, Anti-GABAbR (gamma-aminobutyric acid receptor-B) encephalitis, Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis, Anti-Caspr2 encephalitis (contactin-associated protein-like 2), Anti-glycine receptor (GlyR) antibodies, Anti-mGluR5 (metabotropic glutamate receptor 5), Anti-mGLUR1 (metabotropic glutamate receptor 1), Anti-Hu antibodies, Anti-Ma2 antibodies, Anti-DNER (Delta, Notch-like epidermal growth factor-related receptor) antibodies, Anti-CV2/CRMP5 antibodies
URI
https://observatorio.fm.usp.br/handle/OPI/29956
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/45
Artigos e Materiais de Revistas Científicas - ODS/03