PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ZUMARRAGA, Juan Pablo FMUSP-HC
BATISTA, Felipe Augusto Ribeiro FMUSP-HC
BAPTISTA, Andre Mathias FMUSP-HC
CAIERO, Marcelo Tadeu FMUSP-HC
MARTINO, Luis Pablo De La Rosa FMUSP-HC
CAMARGO, Olavo Pires De FMUSP-HC
dc.date.issued 2018
dc.identifier.citation ACTA ORTOPEDICA BRASILEIRA, v.26, n.5, p.320-324, 2018
dc.identifier.issn 1413-7852
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/30003
dc.description.abstract Objective: Myxofibrosarcoma (MFS) is a common soft tissue sarcoma (STS) that affects the extremities in elderly patients. The objective was to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution. Methods: We retrospectively reviewed the records of 75 patients with MFS. We compared age, sex, tumor size and location, grade and stage of the disease. Median age was 49.7 years (range, 1 to 88 y). Location: upper extremity (25.4%), lower extremity (66.6%) and pelvis (8%). Patients had high-grade tumors in 46.7% of the reports. Margins were negative in 76% of the cases. Bivariate Cox regression analysis was used to determine associations between clinical and treatment factors with local recurrence (LR). Results: Median follow-up time was 30.7 months (range, 1.8 to 383.8 m). We found 26.7% of LR. Distant metastasis (DM) was reported in 27 (36%) patients. Lung was the most common site of DM, reported in 92.6% of patients. Overall survival (OS) with metastasis was 21.2 months (range, 4.8 to 114.8 m). Predictors of OS were grade, LR (hazard ratio [FIR] 5.13, 95% confidence interval, 2.15-12.24, P <0.001), and DM (HR 540.97, 95% confidence interval, 5.04-58112.03, P< 0.001). Conclusions: Tumor grade, LR, positive margins and DM were significant predictors of poor OS prognosis.
dc.language.iso eng
dc.publisher ATHA COMUNICACAO & EDITORA
dc.relation.ispartof Acta Ortopedica Brasileira
dc.rights openAccess
dc.subject Sarcoma; Excision margins; Recurrence; Radiotherapy; Neoplasm metastasis
dc.subject.other high-grade myxofibrosarcoma; sarcoma; variant; impact
dc.title PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA
dc.type article
dc.rights.holder Copyright ATHA COMUNICACAO & EDITORA
dc.description.group LIM/41
dc.identifier.doi 10.1590/1413-785220182605208644
dc.identifier.pmid 30464713
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author ZUMARRAGA, Juan Pablo:FM:
hcfmusp.author BATISTA, Felipe Augusto Ribeiro:HC:IOT
hcfmusp.author BAPTISTA, Andre Mathias:HC:IOT
hcfmusp.author CAIERO, Marcelo Tadeu:HC:IOT
hcfmusp.author MARTINO, Luis Pablo De La Rosa:HC:IOT
hcfmusp.author CAMARGO, Olavo Pires De:FM:MOT
hcfmusp.origem.id WOS:000448984100007
hcfmusp.origem.id 2-s2.0-85056165998
hcfmusp.origem.id SCIELO:S1413-78522018000500320
hcfmusp.publisher.city SAO PAULO SP
hcfmusp.publisher.country BRAZIL
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dc.description.index PubMed
dc.identifier.eissn 1809-4406
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0


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