Characterization of scrotal involvement in children and adolescents with IgA vasculitis
Carregando...
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2018
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
ABRAO, Henrique M.
GOMES, Roberta C.
Citação
ADVANCES IN RHEUMATOLOGY, v.58, article ID 38, 5p, 2018
Resumo
Objective: To characterize scrotal involvement in children and adolescents with IgA vasculitis. Methods: A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Results: Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0-12) vs. 6 (1.3-13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p < 0.0001) and ranitidine use (63% vs. 30%, p = 0.003) were significantly higher in the former group. Conclusions: The scrotal involvement occurred in almost one fifth of IgA vasculitis patients and was commonly evidenced as acute subtype at diagnosis. Scrotal signs/symptoms improved after a prompt use of glucocorticoid and was associated with low frequency of elevated IgA serum levels.
Palavras-chave
IgA vasculitis, Henoch-Schonlein purpura, Scrotal vasculitis, Children, Glucocorticoid, Testicular ultrasound
Referências
- Akcan-Arikan A, 2007, KIDNEY INT, V71, P1028, DOI 10.1038/sj.ki.5002231
- Ben-Sira L, 2000, PEDIATR RADIOL, V30, P125, DOI 10.1007/s002470050029
- Buscatti IM, 2018, CLIN RHEUMATOL, V37, P1319, DOI 10.1007/s10067-017-3972-3
- Calvo-Rio V, 2014, MEDICINE, V93, P106, DOI 10.1097/MD.0000000000000019
- CHAMBERLAIN RS, 1992, PEDIATR EMERG CARE, V8, P213, DOI 10.1097/00006565-199208000-00010
- Chan James C M, 2002, Pediatr Rev, V23, P47, DOI 10.1542/pir.23-2-47
- de Almeida JLJ, 2007, J PEDIAT, V83, P259, DOI [10.2223/JPED.1638, 10.1590/S0021-75572007000400012]
- Gunes M, 2012, TURKISH J PEDIATR, V54, P194
- Ha TS, 2007, ACTA PAEDIATR, V96, P552, DOI 10.1111/j.1651-2227.2006.00173.x
- Jauhola O, 2010, ARCH DIS CHILD, V95, P871, DOI 10.1136/adc.2009.167874
- Kawasaki Yukihiko, 2013, Fukushima J Med Sci, V59, P15
- Kiryluk K, 2011, KIDNEY INT, V80, P79, DOI 10.1038/ki.2011.16
- Lim Y, 2015, ULTRASONOGRAPHY, V34, P144, DOI 10.14366/usg.14042
- Modi S, 2016, UROL CASE REP, V6, P9, DOI 10.1016/j.eucr.2016.01.004
- National Kidney Foundation, 2002, Am J Kidney Dis, V39, pS1
- Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
- Ozen S, 2017, CURR OPIN RHEUMATOL, V29, P530, DOI 10.1097/BOR.0000000000000424
- Ozen S, 2010, ANN RHEUM DIS, V69, P798, DOI 10.1136/ard.2009.116657
- Pacheva IH, 2017, CASE REP PEDIAT, DOI 10.1155/2017/5483543
- Rabelo C, 2008, ACTA REUMATOL PORT, V33, P452
- Rottenstreich Misgav, 2017, BMC Res Notes, V10, P241, DOI 10.1186/s13104-017-2590-0
- Silva CA, 2012, CLIN REV ALLERG IMMU, V42, P256, DOI 10.1007/s12016-011-8281-z
- Suehiro RM, 2007, TURKISH J PEDIATR, V49, P189
- Tabel Y, 2012, IRAN J KIDNEY DIS, V6, P269
- Verim L, 2013, ARCH ITAL UROL ANDRO, V85, P50, DOI 10.4081/aiua.2013.1.50
- Zhao LX, 2017, UROLOGY, V107, P223, DOI 10.1016/j.urology.2017.05.005