Effect of male-specific childhood trauma on telomere length

Imagem de Miniatura
Arquivos
art_XAVIER_Effect_of_malespecific_childhood_trauma_on_telomere_length_2018.PDF (453.63 KB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
XAVIER, Gabriela
SPINDOLA, Leticia M.
OTA, Vanessa K.
CARVALHO, Carolina M.
MAURYA, Pawan Kumar
TEMPAKU, Priscila F.
MORETTI, Patricia N.
MAZOTTI, Diego R.
SATO, Joao Ricardo
BRIETZKE, Elisa
Citação
JOURNAL OF PSYCHIATRIC RESEARCH, v.107, p.104-109, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Child maltreatment (CM) is a global issue with serious lifelong consequences. In fact, maltreatment during childhood might be an important risk factor for the development of psychiatric disorders. Furthermore, previous studies showed a strong relationship between telomere length (TL) and early life stress. Considering that only a few studies have evaluated this relationship in children and that even fewer considered the sex as a possible moderator, we investigated whether TL in the blood of both children and adolescents was associated with psychopathology and with a history of CM, and whether these associations were moderated by the sex. In this cross-sectional study, 561 individuals (ranging between 6 and 14 years of age) from a large prospective community school-based study, i.e., the Brazilian High-Risk Cohort (HRC), were evaluated. The Child Behavior Checklist (CBCL) score was used to assess psychopathology, whereas a latent variable encompassing some questions about history of adverse environment and trauma was employed to determine the CM history. TL was measured in blood cells using a multiplex quantitative polymerase chain reaction. Additionally, TL was inserted in two moderation models, in which the CBCL score/CM, TL and sex were the independent variables, the outcome, and the moderator variable, respectively. Although an association between psychiatric symptoms and TL was not observed, a relation between CM and TL moderated by the sex was seen, indicating that males with higher CM scores presented with shorter telomeres than did females. Our results suggest that child maltreatment could influence telomere length in both children and adolescents and that this effect is mediated by the sex.
Palavras-chave
Psychopathology, Child maltreatment, Children, Adolescents, Telomere length, Sex moderation
URI
https://observatorio.fm.usp.br/handle/OPI/30050
Referências
  1. Alonso-Alvarez C, 2007, P R SOC B, V274, P819, DOI 10.1098/rspb.2006.3764
  2. Anda RF, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-106
  3. Asok A, 2013, DEV PSYCHOPATHOL, V25, P577, DOI 10.1017/S0954579413000011
  4. Barnett D, 1993, ADV APPL DEV PSYCHOL, P7, DOI 10.1016/J.CHIABU.2008.12.003
  5. Bauer Moises E, 2018, Ann N Y Acad Sci, DOI 10.1111/nyas.13712
  6. Benetos A, 2001, HYPERTENSION, V37, P381, DOI 10.1161/01.HYP.37.2.381
  7. Blackburn EH, 2001, CELL, V106, P661, DOI 10.1016/S0092-8674(01)00492-5
  8. Bordin IA, 2013, CAD SAUDE PUBLICA, V29, P13, DOI 10.1590/S0102-311X2013000100004
  9. BROWNE A, 1986, PSYCHOL BULL, V99, P66, DOI 10.1037/0033-2909.99.1.66
  10. Cawthon RM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkn1027
  11. Cen JP, 2015, GYNECOL ENDOCRINOL, V31, P582, DOI 10.3109/09513590.2015.1065478
  12. Chen W, 2011, J GERONTOL A-BIOL, V66, P312, DOI 10.1093/gerona/glq223
  13. Coimbra BM, 2017, J PSYCHIATR RES, V92, P47, DOI 10.1016/j.jpsychires.2017.03.023
  14. Darrow SM, 2016, PSYCHOSOM MED, V78, P776, DOI 10.1097/PSY.0000000000000356
  15. Drury SS, 2012, MOL PSYCHIATR, V17, P719, DOI 10.1038/mp.2011.53
  16. DuMont KA, 2007, CHILD ABUSE NEGLECT, V31, P255, DOI 10.1016/j.chiabu.2005.11.015
  17. Ehrlenbach S, 2009, INT J EPIDEMIOL, V38, P1725, DOI 10.1093/ije/dyp273
  18. Frenck RW, 1998, P NATL ACAD SCI USA, V95, P5607, DOI 10.1073/pnas.95.10.5607
  19. Gardner M, 2014, EXP GERONTOL, V51, P15, DOI 10.1016/j.exger.2013.12.004
  20. Gilbert R, 2009, LANCET, V373, P68, DOI 10.1016/S0140-6736(08)61706-7
  21. Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
  22. Grippo AJ, 2009, STRESS, V12, P1, DOI 10.1080/10253890802046281
  23. Grodstein F, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001590
  24. Hager AD, 2012, CHILD ABUSE NEGLECT, V36, P393, DOI 10.1016/j.chiabu.2012.02.002
  25. Insel T, 2010, AM J PSYCHIAT, V167, P748, DOI 10.1176/appi.ajp.2010.09091379
  26. Insel TR, 2014, AM J PSYCHIAT, V171, P395, DOI 10.1176/appi.ajp.2014.14020138
  27. Ivanova MY, 2007, J CLIN CHILD ADOLESC, V36, P405, DOI 10.1080/15374410701444363
  28. Kaess M, 2018, PSYCHONEUROENDOCRINO, V98, P39, DOI 10.1016/j.psyneuen.2018.08.004
  29. Kawanishi S, 2004, ANN NY ACAD SCI, V1019, P278, DOI 10.1196/annals.1297.047
  30. Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
  31. Kessler RC, 1997, PSYCHOL MED, V27, P1101, DOI 10.1017/S0033291797005588
  32. Krug E. G, 2002, WORLD REPORT VIOLENC
  33. Kyo S, 1999, CANCER RES, V59, P5917
  34. McEwen BS, 2000, BRAIN RES, V886, P172, DOI 10.1016/S0006-8993(00)02950-4
  35. Moller P, 2009, AGING-US, V1, P733
  36. Monroy-Jaramillo N, 2018, WORLD J BIOL PSYCHIA, V19, pS2, DOI 10.1080/15622975.2016.1273550
  37. Muezzinler A, 2013, AGEING RES REV, V12, P509, DOI 10.1016/j.arr.2013.01.003
  38. Pietrek C, 2013, PSYCHIAT RES, V206, P103, DOI 10.1016/j.psychres.2012.11.003
  39. Powell TR, 2018, NEUROPSYCHOPHARMACOL, V43, P445, DOI 10.1038/npp.2017.125
  40. Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
  41. Rao SQ, 2016, J PSYCHIATR RES, V79, P50, DOI 10.1016/j.jpsychires.2016.04.010
  42. Ridout SJ, 2015, ADV PSYCHOSOM MED, V34, P92, DOI 10.1159/000369088
  43. Sahin E, 2011, NATURE, V470, P359, DOI 10.1038/nature09787
  44. Salim S, 2014, CURR NEUROPHARMACOL, V12, P140, DOI 10.2174/1570159X11666131120230309
  45. Salum GA, 2015, INT J METH PSYCH RES, V24, P58, DOI 10.1002/mpr.1459
  46. Samplin E, 2013, J PSYCHIATR RES, V47, P1174, DOI 10.1016/j.jpsychires.2013.05.008
  47. Schiavone S, 2013, ANTIOXID REDOX SIGN, V18, P1475, DOI 10.1089/ars.2012.4720
  48. Schutte NS, 2015, DEPRESS ANXIETY, V32, P229, DOI 10.1002/da.22351
  49. Shalev I, 2013, MOL PSYCHIATR, V18, P576, DOI 10.1038/mp.2012.32
  50. Steenstrup T, 2013, EUR J EPIDEMIOL, V28, P181, DOI 10.1007/s10654-013-9780-4
  51. Tiwari A, 2018, CLIN PSYCHOL REV
  52. Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
  53. Tyrka AR, 2010, BIOL PSYCHIAT, V67, P531, DOI 10.1016/j.biopsych.2009.08.014
  54. Weber K, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-63
  55. Wojcicki JM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.71
  56. Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
  57. Zalli A, 2014, P NATL ACAD SCI USA, V111, P4519, DOI 10.1073/pnas.1322145111

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - ODS/16