Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

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art_KAHLES_Comprehensive_Analysis_of_Alternative_Splicing_Across_Tumors_from_2018.PDF (40.72 MB)
Citações na Scopus
561
Tipo de produção
article
Data de publicação
2018
Editora
CELL PRESS
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
KAHLES, Andre
LEHMANN, Kjong-Van
TOUSSAINT, Nora C.
HUSER, Matthias
STARK, Stefan G.
SACHSENBERG, Timo
STEGLE, Oliver
KOHLBACHER, Oliver
SANDER, Chris
RATSCH, Gunnar
Autor de Grupo de pesquisa
Canc Genome Atlas Res Network
Editores
Coordenadores
Organizadores
Citação
CANCER CELL, v.34, n.2, p.211-224.e6, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alternative splicing events than normal samples. Association analysis of somatic variants with alternative splicing events confirmed known trans associations with variants in SF3B1 and U2AF1 and identified additional trans-acting variants (e.g., TADA1, PPP2R1A). Many tumors have thousands of alternative splicing events not detectable in normal samples; on average, we identified approximate to 930 exon-exon junctions (""neojunctions'') in tumors not typically found in GTEx normals. From Clinical Proteomic Tumor Analysis Consortium data available for breast and ovarian tumor samples, we confirmed approximate to 1.7 neojunction- and approximate to 0.6 single nucleotide variant-derived peptides per tumor sample that are also predicted major histocompatibility complex-I binders (""putative neoantigens'').
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URI
https://observatorio.fm.usp.br/handle/OPI/30091
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - ODS/03