Combined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopause

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Arquivos
art_SHIMOJO_Combined_Aerobic_and_Resistance_Exercise_Training_Improve_Hypertension_2018.PDF (1.56 MB)
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
SHIMOJO, Guilherme Lemos
DIAS, Danielle da Silva
MALFITANO, Christiane
SANCHES, Iris Callado
LLESUY, Susana
ULLOA, Luis
ANGELIS, Katia De
Autor de Grupo de pesquisa
Citação
FRONTIERS IN PHYSIOLOGY, v.9, article ID 1471, 11p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HRO), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HRO group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.
Palavras-chave
combined exercise training, ovariectomy, hypertension, cardiovascular autonomic dysfunction, oxidative stress, inflammation, kidney
URI
https://observatorio.fm.usp.br/handle/OPI/30230
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/59