Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/30298
Title: | Salivary shedding of herpesviruses in renal transplant recipients |
Authors: | SARMENTO, Dmitry Jose de Santana; CALIENTO, Rubens; SOUZA, Amabile Oliveira de; TOZETTO-MENDOZA, Tania Regina; PALMIERI, Michelle; MARTINS, Victor Adriano de Oliveira; BRAZ-SILVA, Paulo Henrique; GALLOTTINI, Marina |
Citation: | JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY, v.9, n.4, article ID e12356, 6p, 2018 |
Abstract: | Aim The aim of the present study was to describe the salivary shedding of human herpesviruses (HHV) in renal transplant recipients and to observe the oral manifestations in this group. Methods A prospective case-control study was conducted with a study group of 20 renal transplant recipients and a control group of 20 non-transplanted, immunocompetent individuals. Clinical examination evaluated the presence of drug-induced gingival overgrowth (DIGO), salivary flow, and caries. Stimulated saliva was collected from both groups, with HHV being detected by using real-time polymerase chain reaction. Results The mean age of the study group was 45.90 +/- 9.89 years, with 55% (11/20) being female, 60% (12/20) being Caucasian, 65% (13/20) having a deceased donor, and 70% (14/20) having used tacrolimus as the main immunosuppressive drug. Renal transplant recipients had shedding of more herpesviruses compared to the control group, with the exception of HHV-7. Statistical significance was found for herpes simplex virus-1 (HSV-1) (P = 0.017) and cytomegalovirus (P = 0.035). DIGO was observed in seven patients (35%), with 35% (7/20) presenting with decreased salivary flow and four (20%) reporting xerostomia. Conclusion Renal transplant recipients excreted herpesviruses more often than control individuals, especially HSV-1. Decreased salivary flow and xerostomia were more frequent in patients who used tacrolimus, whereas those who used cyclosporine had more cases of DIGO. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/52 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SARMENTO_Salivary_shedding_of_herpesviruses_in_renal_transplant_recipients_2018.PDF Restricted Access | publishedVersion (English) | 288.45 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.