Classic congenital adrenal hyperplasia and its impact on reproduction
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Citações na Scopus
39
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autor de Grupo de pesquisa
Citação
FERTILITY AND STERILITY, v.111, n.1, p.7-12, 2019
Resumo
Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11 beta-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a diminished desire to conceive. Optimal glucocorticoid and/or mineralocorticoid replacement, sufficient to normalize androgen and P levels in the follicular phase, allows natural conception in most cases. The remaining CAH forms exemplified by StAR, P450scc, P450-oxidoreductase, and 17 alpha-hydroxylase/17-20 lyase deficiencies are associated with impaired sex steroid production. Several factors are involved in the true low fertility rate in this group: folliculogenesis arrest, uterine hypoplasia, and inadequate endometrial thickness related to aberrant androgen, estrogen, and P secretion. There are several reports of successful term pregnancies achieved through controlled ovarian hyperstimulation, followed by estrogen replacement and IVF. Progress in female genitalia reconstructive surgery, individualized hormonal therapies, psychosexual evaluation, and assisted reproductive technology have improved fertility and pregnancy outcomes in women with classic CAH. Finally, successful gestational management in CAH patients requires the close coordination of care between endocrinologists and obstetricians. (C) 2018 by American Society for Reproductive Medicine.
Palavras-chave
Congenital adrenal hyperplasia, fertility, reproduction
Referências
- Alos N, 2000, J CLIN ENDOCR METAB, V85, P1968, DOI 10.1210/jc.85.5.1968
- Auchus RJ, 2004, TRENDS ENDOCRIN MET, V15, P432, DOI 10.1016/j.tem.2004.09.004
- Auchus RJ, 2001, ENDOCRIN METAB CLIN, V30, P101, DOI 10.1016/S0889-8529(08)70021-5
- Bachelot A, 2012, EUR J ENDOCRINOL, V167, P499, DOI 10.1530/EJE-12-0454
- Bonamichi BDSF, 2016, ARCH ENDOCRIN METAB, V60, P500, DOI 10.1590/2359-3997000000213
- Bose HS, 1996, NEW ENGL J MED, V335, P1870, DOI 10.1056/NEJM199612193352503
- Casteras A, 2009, CLIN ENDOCRINOL, V70, P833, DOI 10.1111/j.1365-2265.2009.03563.x
- Chien Y, 2013, BIOL REPROD, V89, DOI 10.1095/biolreprod.113.110833
- Costa EMF, 1997, FERTIL STERIL, V67, P229
- de Carvalho LC, 2016, FERTIL STERIL, V105, P1612, DOI 10.1016/j.fertnstert.2016.02.008
- Bianchi PHD, 2016, J CLIN ENDOCR METAB, V101, P345, DOI 10.1210/jc.2015-3201
- Fluck CE, 2004, NAT GENET, V36, P228, DOI 10.1038/ng1300
- Fluck CE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020178
- Fluck CE, 2011, ENDOCR DEV, V20, P63, DOI 10.1159/000321221
- Fujieda K, 1997, J CLIN INVEST, V99, P1265, DOI 10.1172/JCI119284
- Fukami M, 2009, J CLIN ENDOCR METAB, V94, P1723, DOI 10.1210/jc.2008-2816
- Guaragna G, 2012, ARQ BRAS ENDOCRINOL, V56, P578, DOI 10.1590/S0004-27302012000800020
- HAGUE WM, 1990, CLIN ENDOCRINOL, V33, P501, DOI 10.1111/j.1365-2265.1990.tb03887.x
- Hauffa B, 2011, ENDOCR DEV, V20, P54, DOI 10.1159/000321215
- Hershkovitz E, 2008, J CLIN ENDOCR METAB, V93, P3584, DOI 10.1210/jc.2008-0051
- Hoepffner W, 2004, FERTIL STERIL, V81, P1314, DOI 10.1016/j.fertnstert.2003.10.024
- HOLMESWALKER DJ, 1995, CLIN ENDOCRINOL, V43, P291
- Idkowiak J, 2011, J CLIN ENDOCR METAB, V96, pE453, DOI 10.1210/jc.2010-1607
- Jaaskelainen J, 2000, ACTA OBSTET GYN SCAN, V79, P687, DOI 10.1034/j.1600-0412.2000.079008687.x
- Khattab A, 2017, P NATL ACAD SCI USA, V114, pE1933, DOI [10.1073/pnas.1621082114, 10.1073/pnas.1621082114/-/DCSupplemental]
- Khoury K, 2009, J CLIN ENDOCR METAB, V94, P1333, DOI 10.1210/jc.2008-1694
- Kim Chan Jong, 2014, Ann Pediatr Endocrinol Metab, V19, P179, DOI 10.6065/apem.2014.19.4.179
- Levran D, 2003, J ASSIST REPROD GEN, V20, P21, DOI 10.1023/A:1021206704958
- Lim JJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09880-0
- Lo JC, 2001, ENDOCRIN METAB CLIN, V30, P207, DOI 10.1016/S0889-8529(08)70027-6
- Marsh CA, 2014, FERTIL STERIL, V101, P317, DOI 10.1016/j.fertnstert.2013.11.011
- Martin RM, 2003, J CLIN ENDOCR METAB, V88, P5739, DOI 10.1210/jc.2003-030988
- Mermejo LM, 2005, J CLIN ENDOCR METAB, V90, P1287, DOI 10.1210/jc.2004-1552
- Meyer-Bahlburg HFL, 2008, ARCH SEX BEHAV, V37, P85, DOI 10.1007/s10508-007-9265-1
- Meyer-Bahlburg HFL, 2006, ARCH SEX BEHAV, V35, P667, DOI 10.1007/s10508-006-9068-9
- Miller WL, 1998, CLIN PERINATOL, V25, P799
- Miller WL, 2005, ENDOCRINOLOGY, V146, P2544, DOI 10.1210/en.2005-0096
- Miura K, 1996, J CLIN ENDOCR METAB, V81, P3797, DOI 10.1210/jc.81.10.3797
- Moore AM, 2016, J STEROID BIOCHEM, V160, P106, DOI 10.1016/j.jsbmb.2015.10.002
- MULAIKAL RM, 1987, NEW ENGL J MED, V316, P178, DOI 10.1056/NEJM198701223160402
- Nordenstrom A, 2010, J CLIN ENDOCR METAB, V95, P3633, DOI 10.1210/jc.2009-2639
- Ogilvie CM, 2006, EUR J ENDOCRINOL, V154, P405, DOI 10.1530/eje.1.02096
- Peter M, 2002, SEMIN REPROD MED, V20, P249, DOI 10.1055/s-2002-35389
- Pielecka J, 2006, ENDOCRINOLOGY, V147, P1474, DOI 10.1210/en.2005-1029
- Reichman DE, 2014, FERTIL STERIL, V101, P301, DOI 10.1016/j.fertnstert.2013.11.002
- Sertedaki A, 2009, FERTIL STERIL, V91, DOI 10.1016/j.fertnstert.2008.07.1770
- Simard J, 1996, J ENDOCRINOL, V150, pS189
- Simitsidellis I, 2018, MOL CELL ENDOCRINOL, V465, P48, DOI 10.1016/j.mce.2017.09.022
- Simm PJ, 2007, HORM RES, V68, P294, DOI 10.1159/000107651
- Sircili Maria Helena Palma, 2006, Clinics, V61, P209, DOI 10.1590/S1807-59322006000300005
- Solorzano CMB, 2010, BJOG-INT J OBSTET GY, V117, P143, DOI 10.1111/j.1471-0528.2009.02383.x
- Song TR, 2018, GYNECOL ENDOCRINOL, V34, P385, DOI 10.1080/09513590.2017.1393663
- Sowikowska-Hilczer J, 2017, FERTIL STERIL, V108, P822, DOI 10.1016/j.fertnstert.2017.08.013
- Speiser PW, 2018, J CLIN ENDOCR METAB, V103, P4043, DOI 10.1210/jc.2018-01865
- Speiser PW, 2010, J CLIN ENDOCR METAB, V95, P4133, DOI 10.1210/jc.2009-2631
- Walters KA, 2018, MOL CELL ENDOCRINOL, V465, P36, DOI 10.1016/j.mce.2017.06.026
- White PC, 2012, SEMIN REPROD MED, V30, P400, DOI 10.1055/s-0032-1324724
- Wisniewski AB, 2004, J UROLOGY, V171, P2497, DOI 10.1097/01.ju.0000125269.91938.f7
- ZACHMANN M, 1970, J CLIN ENDOCR METAB, V30, P719, DOI 10.1210/jcem-30-6-719
- ZACHMANN M, 1979, HORM RES, V11, P292, DOI 10.1159/000179067