Persistent pain is a risk factor for frailty: a systematic review and meta-analysis from prospective longitudinal studies

Imagem de Miniatura
Arquivos
art_SARAIVA_Persistent_pain_is_a_risk_factor_for_frailty_2018.PDF (325.29 KB)
Citações na Scopus
62
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
Citação
AGE AND AGEING, v.47, n.6, p.785-793, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: pain is prevalent in frail older adults; however, the association of pain and frailty has not been evaluated yet by a systematic assessment of prospective longitudinal studies. Objective: we aimed to assess the association of persistent pain as a risk factor for frailty incidence, using data from longitudinal studies in a systematic review and meta-analysis. Methods: publications were identified using a systematic search on PubMed, Embase, Cochrane Library and clinicaltrials. gov databases from inception to October 2017. Since heterogeneity across studies was high, we used random-effects metaanalysis to calculate the pooled relative risk for the association between persistent pain and the incidence of frailty. We investigated sources of heterogeneity among studies using meta-regression and stratified analyses. Results: we included five prospective longitudinal studies with 13,120 participants (46% women, mean age from 59 to 85 years old). Participants with persistent pain at baseline had twice the risk of developing frailty during the follow-up (pooled RR = 2.22, 95% CI = 1.14-4.29). No variables were related to study heterogeneity in sensitivity analyses. Conclusion: persistent pain was a risk factor for the development of frailty in a meta-analysis of longitudinal studies. Better understanding of the association between pain and frailty with proper evaluation of potential confounders could allow the development of targeted interventions.
Palavras-chave
frailty, frail older people, meta-analysis, pain, persistent pain, systematic review
URI
https://observatorio.fm.usp.br/handle/OPI/30791
Referências
  1. Blyth FM, 2008, PAIN, V140, P224, DOI 10.1016/j.pain.2008.08.011
  2. Brown L, 2015, REV CLIN GERONTOL, V25, P159, DOI 10.1017/S0959259815000143
  3. Collard RM, 2012, J AM GERIATR SOC, V60, P1487, DOI 10.1111/j.1532-5415.2012.04054.x
  4. Dapp U, 2014, BMC GERIATR, V14, DOI 10.1186/1471-2318-14-141
  5. de Andrade DC, 2011, ARQ NEURO-PSIQUIAT, V69, P387, DOI 10.1590/S0004-282X2011000300023
  6. Ensrud KE, 2009, J AM GERIATR SOC, V57, P492, DOI 10.1111/j.1532-5415.2009.02137.x
  7. Ferrell B, 2002, J AM GERIATR SOC, V50, pS205
  8. Ferrer A, 2015, QUAL LIFE RES, V24, P2701, DOI 10.1007/s11136-015-1004-9
  9. Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
  10. Fried LP, 2004, J GERONTOL A-BIOL, V59, P255
  11. Gibson SJ, 2004, CLIN J PAIN, V20, P227, DOI 10.1097/00002508-200407000-00004
  12. Hadjistavropoulos T, 2007, CLIN J PAIN, V23, pS1, DOI 10.1097/AJP.0b013e31802be869
  13. Harris RJ, 2008, STATA J, V8, P3, DOI 10.1177/1536867X0800800102
  14. Higgins JPT, 2003, BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
  15. Higgins JPT, 2011, COCHRANE HDB SYSTEMA, DOI 10.1002/9780470712184
  16. Lariviere M, 2007, CLIN J PAIN, V23, P506, DOI 10.1097/AJP.0b013e31806a23e8
  17. Ferreira KASL, 2016, ARQ NEURO-PSIQUIAT, V74, P990, DOI [10.1590/0004-282x20160156, 10.1590/0004-282X20160156]
  18. Lohman MC, 2017, J GERONTOL A-BIOL, V72, P216, DOI 10.1093/gerona/glw212
  19. Maxwell CJ, 2008, PAIN, V138, P208, DOI 10.1016/j.pain.2008.04.007
  20. Morley JE, 2012, J NUTR HEALTH AGING, V16, P601, DOI 10.1007/s12603-012-0084-2
  21. Rastogi R, 2013, CLIN INTERV AGING, V8, P37, DOI 10.2147/CIA.S30165
  22. Rockwood K, 2007, J GERONTOL A-BIOL, V62, P738, DOI 10.1093/gerona/62.7.738
  23. Shega JW, 2012, J AM GERIATR SOC, V60, P113, DOI 10.1111/j.1532-5415.2011.03769.x
  24. Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
  25. Thomas E, 2007, PAIN, V129, P21, DOI 10.1016/j.pain.2006.09.027
  26. Van Kan GA, 2008, J NUTR HEALTH AGING, V12, P29, DOI 10.1007/BF02982161
  27. Veronese N, 2017, PAIN MED, V18, P414, DOI 10.1093/pm/pnw163
  28. Wade KF, 2017, J GERONTOL A-BIOL, V72, P403, DOI 10.1093/gerona/glw226
  29. Wade KF, 2016, AGE AGEING, V45, P268, DOI 10.1093/ageing/afv170
  30. Wells GA, 2013, NEWCASTLE OTTAWA SCA

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - LIM/26