Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury

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art_DOLAN_Beyond_muscle_the_effects_of_creatine_supplementation_on_2019.PDF (636.08 KB)
Citações na Scopus
71
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS LTD
Autores
RAWSON, Eric S.
Citação
EUROPEAN JOURNAL OF SPORT SCIENCE, v.19, n.1, Special Issue, p.1-14, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The ergogenic and therapeutic effects of increasing muscle creatine by supplementation are well-recognized. It appears that similar benefits to brain function and cognitive processing may also be achieved with creatine supplementation, however research in this area is more limited, and important knowledge gaps remain. The purpose of this review is to provide a comprehensive overview of the current state of knowledge about the influence of creatine supplementation on brain function in healthy individuals. It appears that brain creatine is responsive to supplementation, however higher, or more prolonged dosing strategies than those typically used to increase muscle creatine, may be required to elicit an increase in brain creatine. The optimal dosing strategy to induce this response, is currently unknown, and there is an urgent need for studies investigating this. When considering the influence of supplementation strategies on cognitive processes, it appears that creatine is most likely to exert an influence in situations whereby cognitive processes are stressed, e.g. during sleep deprivation, experimental hypoxia, or during the performance of more complex, and thus more cognitively demanding tasks. Evidence exists indicating that increased brain creatine may be effective at reducing the severity of, or enhancing recovery from mild traumatic brain injury, however, only limited data in humans are available to verify this hypothesis, thus representing an exciting area for further research.
Palavras-chave
Phosphorylcreatine, cerebral energy metabolism, dietary supplement, cognition, concussion
URI
https://observatorio.fm.usp.br/handle/OPI/30802
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/17