Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation

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Arquivos
art_ALVES_KininB2_Receptor_Activity_in_Skeletal_Muscle_Regeneration_and_2019.PDF (5.26 MB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HUMANA PRESS INC
Autores
ALVES, Janaina M.
MARTINS, Antonio H.
LAMEU, Claudiana
GLASER, Talita
BOUKLI, Nawal M.
BASSANEZE, Vinicius
NASCIMENTO, Isis C.
MARTINS, Poliana C. M.
SOUZA, Hellio D. N. de
Citação
STEM CELL REVIEWS AND REPORTS, v.15, n.1, p.48-58, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The bioactive peptide bradykinin obtained from cleavage of precursor kininogens activates the kinin-B2 receptor functioning in induction of inflammation and vasodilatation. In addition, bradykinin participates in kidney and cardiovascular development and neuronal and muscle differentiation. Here we show that kinin-B2 receptors are expressed throughout differentiation of murine C2C12 myoblasts into myotubes. An autocrine loop between receptor activation and bradykinin secretion is suggested, since bradykinin secretion is significantly reduced in the presence of the kinin-B2 receptor antagonist HOE-140 during differentiation. Expression of skeletal muscle markers and regenerative capacity were decreased after pharmacological inhibition or genetic ablation of the B2 receptor, while its antagonism increased the number of myoblasts in culture. In summary, the present work reveals to date no functions described for the B2 receptor in muscle regeneration due to the control of proliferation and differentiation of muscle precursor cells.
Palavras-chave
Mouse myoblast differentiation, Muscle repair, Kinin-B2 receptor, HOE-140
URI
https://observatorio.fm.usp.br/handle/OPI/30816
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13