Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

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art_PULIT_Atrial_fibrillation_genetic_risk_differentiates_cardioembolic_stroke_from_2018.PDF (482.15 KB)
Citações na Scopus
35
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
PULIT, Sara L.
WENG, Lu-Chen
MCARDLE, Patrick F.
TRINQUART, Ludovic
CHOI, Seung Hoan
MITCHELL, Braxton D.
ROSAND, Jonathan
BAKKER, Paul I. W. de
BENJAMIN, Emelia J.
ELLINOR, Patrick T.
Autor de Grupo de pesquisa
Atrial Fibrillation Genetics Conso
Int Stroke Genetics Consortium
Citação
NEUROLOGY-GENETICS, v.4, n.6, article ID UNSP e293, 8p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. Methods We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Results We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Conclusions Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/30824
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/03