Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/30829
Title: Effects of ketamine/xylazine and isoflurane on rat brain glucose metabolism measured by F-18-fluorodeoxyglucose-positron emission tomography
Authors: PRANDO, SilvanaCARNEIRO, Camila de GodoiOTSUKI, Denise AyaSAPIENZA, Marcelo Tatit
Citation: EUROPEAN JOURNAL OF NEUROSCIENCE, v.49, n.1, p.51-61, 2019
Abstract: The aim of the present study was to investigate changes in glucose metabolism in male Wistar rats induced by the anesthetics isoflurane and ketamine combined with xylazine via F-18-fluorodeoxyglucose-positron emission tomography. We analyzed the differential effects of the anesthetics on F-18-fluorodeoxyglucose uptake and pharmacokinetics in 33 rats using quantification methods: (a) the standardized uptake value, (b) voxel-based analyses, and (c) kinetic analysis. Both anesthetics reduced glucose uptake in the entire brain. The voxel-based analyses detected smaller uptake reductions in the bilateral primary somatosensory system cortex and part of the limbic system in the ketamine-xylazine (KX) group and in the vestibular nucleus in the isoflurane group. Through kinetic analysis, we found that the volume of distribution and the membrane transport rate K-1 were reduced in the KX group. Through various methods of F-18-fluorodeoxyglucose-positron emission tomography quantification, the present study found that anesthesia with the ketamine-xylazine combination induced a global reduction of glucose metabolism compared with isoflurane; this reduction of metabolism was relatively lower in the primary somatosensory cortex and part of the limbic system. The volume of distribution of F-18-fluorodeoxyglucose and its Glut1-mediated transport across the brain membranes (K-1) were decreased in the KX group.
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Instituto do Câncer do Estado de São Paulo - HC/ICESP

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