Effects of ketamine/xylazine and isoflurane on rat brain glucose metabolism measured by F-18-fluorodeoxyglucose-positron emission tomography
Carregando...
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2019
Editora
WILEY
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
EUROPEAN JOURNAL OF NEUROSCIENCE, v.49, n.1, p.51-61, 2019
Resumo
The aim of the present study was to investigate changes in glucose metabolism in male Wistar rats induced by the anesthetics isoflurane and ketamine combined with xylazine via F-18-fluorodeoxyglucose-positron emission tomography. We analyzed the differential effects of the anesthetics on F-18-fluorodeoxyglucose uptake and pharmacokinetics in 33 rats using quantification methods: (a) the standardized uptake value, (b) voxel-based analyses, and (c) kinetic analysis. Both anesthetics reduced glucose uptake in the entire brain. The voxel-based analyses detected smaller uptake reductions in the bilateral primary somatosensory system cortex and part of the limbic system in the ketamine-xylazine (KX) group and in the vestibular nucleus in the isoflurane group. Through kinetic analysis, we found that the volume of distribution and the membrane transport rate K-1 were reduced in the KX group. Through various methods of F-18-fluorodeoxyglucose-positron emission tomography quantification, the present study found that anesthesia with the ketamine-xylazine combination induced a global reduction of glucose metabolism compared with isoflurane; this reduction of metabolism was relatively lower in the primary somatosensory cortex and part of the limbic system. The volume of distribution of F-18-fluorodeoxyglucose and its Glut1-mediated transport across the brain membranes (K-1) were decreased in the KX group.
Palavras-chave
anesthetics, brain energy metabolism, F-18-Fluorodeoxyglucose, positron emission tomography, Wistar
Referências
- Alstrup AKO, 2013, LAB ANIM-UK, V47, P12, DOI 10.1258/la.2012.011173
- Bergeron M, 2014, PHYS MED BIOL, V59, P661, DOI 10.1088/0031-9155/59/3/661
- Bergeron M, 2009, IEEE T NUCL SCI, V56, P10, DOI 10.1109/TNS.2008.2010257
- Brown E. N., 2015, MILLERS ANESTHESIA, P1524
- CARRUBA MO, 1987, EUR J PHARMACOL, V134, P15, DOI 10.1016/0014-2999(87)90126-9
- Freo U, 2004, ANESTHESIOLOGY, V100, P1172, DOI 10.1097/00000542-200405000-00020
- Hemmings HC, 2005, TRENDS PHARMACOL SCI, V26, P503, DOI 10.1016/j.tips.2005.08.006
- Jespersen B, 2012, JOVE-J VIS EXP, DOI 10.3791/3496
- Lancelot S, 2010, TRENDS PHARMACOL SCI, V31, P411, DOI 10.1016/j.tips.2010.06.002
- Langsjo JW, 2005, ANESTHESIOLOGY, V103, P258
- Lee MS, 2010, VET RADIOL ULTRASOUN, V51, P130, DOI 10.1111/j.1740-8261.2009.01636.x
- Matsumura A, 2003, NEUROIMAGE, V20, P2040, DOI 10.1016/j.neuroimage.2003.08.020
- Mizuma H, 2010, J NUCL MED, V51, P1068, DOI 10.2967/jnumed.110.075184
- Noda A, 2003, J CEREBR BLOOD F MET, V23, P1441, DOI 10.1097/01.WCB.0000090623.86921.47
- ORZI F, 1988, J CEREBR BLOOD F MET, V8, P346, DOI 10.1038/jcbfm.1988.70
- PATLAK CS, 1985, J CEREBR BLOOD F MET, V5, P584, DOI 10.1038/jcbfm.1985.87
- PATLAK CS, 1983, J CEREBR BLOOD F MET, V3, P1, DOI 10.1038/jcbfm.1983.1
- Paxinos G, 2007, RAT BRAIN STEREOTAXI
- Purdon PL, 2015, ANESTHESIOLOGY, V123, P937, DOI 10.1097/ALN.0000000000000841
- Saha JK, 2005, EXP BIOL MED, V230, P777, DOI 10.1177/153537020523001012
- Sano Y, 2016, AM J PHYSIOL-HEART C, V311, pH1360, DOI 10.1152/ajpheart.00181.2016
- Schwarz AJ, 2006, NEUROIMAGE, V32, P538, DOI 10.1016/j.neuroimage.2006.04.214
- Shimoji K, 2004, J NUCL MED, V45, P665
- SOKOLOFF L, 1977, J NEUROCHEM, V28, P897, DOI 10.1111/j.1471-4159.1977.tb10649.x
- Spangler-Bickell MG, 2016, EJNMMI RES, V6, DOI 10.1186/s13550-016-0242-3
- STRAUSS LG, 1991, J NUCL MED, V32, P623
- Toyama H, 2004, NUCL MED BIOL, V31, P251, DOI 10.1016/S0969-8051(03)00124-0
- Toyama H, 2004, J NUCL MED, V45, P1398
- Vallez Garcia D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122363
- Viglianti BL, 2017, BIOMED PHARMACOTHER, V88, P1038, DOI 10.1016/j.biopha.2017.01.166
- Watson GDR, 2017, J COMP NEUROL, V525, P1363, DOI 10.1002/cne.23981
- Wu HM, 2007, J NUCL MED, V48, P837, DOI 10.2967/jnumed.106.038182
Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/43
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/43