Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author TENGAN, Fatima Mitiko FMUSP-HC
FIGUEIREDO, Gerusa M. FMUSP-HC
NUNES, Arielle K. S. FMUSP-HC
MANCHIERO, Carol FMUSP-HC
DANTAS, Bianca P. FMUSP-HC
MAGRI, Mariana C. FMUSP-HC
PRATA, Thamiris V. G. FMUSP-HC
NASCIMENTO, Marisa
MAZZA, Celso C. FMUSP-HC
ABDALA, Edson FMUSP-HC
BARONE, Antonio A. FMUSP-HC
BERNARDO, Wanderley M. FMUSP-HC
dc.date.issued 2019
dc.identifier.citation INFECTIOUS DISEASES OF POVERTY, v.8, article ID 3, 10p, 2019
dc.identifier.issn 2095-5162
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/30854
dc.description.abstract BackgroundHepatitis E virus (HEV) is a member of the Hepeviridae family; it has four main genotypes and one serotype. While genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route, genotypes 3 and 4 are zoonotic. In the various seroprevalence studies of hepatitis E in Brazil, the numbers reported vary widely and are difficult to interpret. The aim of this study was to analyze existing seroprevalence studies of hepatitis E in adults in Brazil.Main textWe searched the PubMed, Latin American and Caribbean Health Sciences and Embase databases for studies published from inception to May 12, 2018 concerning infection by HEV in Brazil without time period or language restrictions. We included studies that presented data concerning hepatitis E seroprevalence in adults in Brazil, had a sample size 50 patients and whose method used for the detection of anti-HEV was standardized and commercialized. We also evaluated the quality of the articles using a list of criteria that totalized 9 items. Of the 20 studies ultimately analyzed, 10 (50%) were from the southeast region of Brazil, 3 (15%) were from the central-west region, 3 (15%) were from the northern region, 2 (10%) were from the northeast region and 2 (10%) were from the southern region. Regarding the quality evaluation of the studies, the mean score was 5.6 (range: 4-8). The estimated overall seroprevalence of HEV infection in the adult population was 6.0% (95% CI: 5.0-7.0); in subgroup analyses, we observed that the prevalence of anti-HEV antibodies in blood donors was 7.0% (95% CI: 5.0-8.0), whereas in the general population, it was 3.0% (95% CI: 2.0-4.0).ConclusionsThe results of this systematic review indicate that there should be national investment in the prevention of hepatitis E virus infection in Brazil, including the implementation of improvements in basic sanitation and guidance regarding the appropriate handling of animal waste and the optimal cooking of vegetables, meat and their derivatives.
dc.language.iso eng
dc.publisher BMC
dc.relation.ispartof Infectious Diseases of Poverty
dc.rights openAccess
dc.subject Hepatitis E; Hepatitis E virus; Brazil; Prevalence; Systematic review
dc.subject.other e virus-infection; local grocery stores; pig livers sold; blood-donors; transplant recipients; high prevalence; risk-factors; 1st report; genotype 4; antibodies
dc.title Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis
dc.type article
dc.rights.holder Copyright BMC
dc.description.group LIM/47
dc.description.group LIM/52
dc.identifier.doi 10.1186/s40249-018-0514-4
dc.identifier.pmid 30646964
dc.type.category review
dc.type.version publishedVersion
hcfmusp.author TENGAN, Fatima Mitiko:FM:MIP
hcfmusp.author FIGUEIREDO, Gerusa M.:IMT:IMT
hcfmusp.author NUNES, Arielle K. S.:FM:
hcfmusp.author MANCHIERO, Carol:HC:ICHC
hcfmusp.author DANTAS, Bianca P.:HC:INCOR
hcfmusp.author MAGRI, Mariana C.:FM:
hcfmusp.author PRATA, Thamiris V. G.:FM:
hcfmusp.author MAZZA, Celso C.:HC:ICHC
hcfmusp.author ABDALA, Edson:FM:MIP
hcfmusp.author BARONE, Antonio A.:FM:MIP
hcfmusp.author BERNARDO, Wanderley M.:FM:
hcfmusp.author.external · NASCIMENTO, Marisa:Univ Sao Paulo, Sch Med, Clin Hosp, Nursing Div, Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000455822000001
hcfmusp.origem.id 2-s2.0-85060032636
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
dc.identifier.eissn 2049-9957
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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