Molecular characterization of viruses associated with encephalitis in Sao Paulo, Brazil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP FERREIRA, Jerenice E. FMUSP-HC
GOMES, Helio
SANTOSID, Raimunda Telma de Macedo
WITKIN, Steven S.
SABINO, Ester C. FMUSP-HC 2019
dc.identifier.citation PLOS ONE, v.14, n.1, article ID e0209993, 10p, 2019
dc.identifier.issn 1932-6203
dc.description.abstract The objective of this study was to characterize the prevalence of viral encephalitis due to arbovirus infection of the Togaviridae and Flaviviridae families in Sao Paulo, Brazil. A total of 500 cerebrospinal fluid (CSF) samples collected between August 2012 and January 2013, from patients with symptoms of acute encephalitis were analyzed. Findings suggestive of viral encephalitis-elevations in cell concentration, glucose and total protein-were observed in 234 (46.8%) samples, designated as Group 1. The remaining 266 samples comprised Group 2. All samples were tested for Flaviviruses (dengue virus 1, 2, 3 and 4, yellow fever virus and West Nile virus), Alphavirus (NS5 region) and enterovirus by RT-PCR and for herpesviruses and enteroviruses using CLART(-)Entherpex. A presumptive viral etiological agent was detected in 26 samples (5.2%), 18 (8.0%) in Group 1 and 8 (3.0%) in Group 2. In Group 1 human herpesviruses were detected in 9 cases, enteroviruses in 7 cases, dengue viruses (DENV) in 2 CSFs and St. Louis encephalitis virus (SLEV) in one case. In Group 2 there were 3 CSFs positive for human herpesviruses, 2 for enteroviruses, 2 for DENV and 1 for SLEV. Detection of arboviruses, even though present in a minority of infected patients, identifies these viruses as a probable etiological agent of encephalitis. This is of special concern in regions where this class of viruses is endemic and has been linked to other recent epidemics.
dc.description.sponsorship · Foundation for Research Support of the State of Sao Paulo (FAPESP) [2011/52094-3]
dc.language.iso eng
dc.relation.ispartof Plos One
dc.rights openAccess
dc.subject.other zika virus; pcr assays; dengue; infections; epidemiology; enterovirus; diseases
dc.title Molecular characterization of viruses associated with encephalitis in Sao Paulo, Brazil
dc.type article
dc.rights.holder Copyright PUBLIC LIBRARY SCIENCE LIM/03 LIM/21 LIM/46
dc.identifier.doi 10.1371/journal.pone.0209993
dc.identifier.pmid 30640927
dc.type.category original article
dc.type.version publishedVersion FERREIRA, Jerenice E.:IMT: ALMEIDA-NETO, Cesar:HC:ICHC ALENCAR, Cecilia S.:HC:ICHC GOUVEIA, Gisele R.:FM:MPS CAIAFFA-FILHO, Helio:HC:ICHC SABINO, Ester C.:FM:MIP · FERREIRA, Suzete C.:FPS HSP, Sao Paulo, Brazil
· NISHIYA, Anna S.:FPS HSP, Sao Paulo, Brazil
· GOMES, Helio:HCSP, DLC, Cent Lab Div, Sao Paulo, Brazil; Univ Sao Paulo, Med Sch, Dept Clin Hosp, Clin Lab, Sao Paulo, Brazil; Univ Sao Paulo, Med Sch, Dept Clin Hosp, LIM 03, Sao Paulo, Brazil
· SANTOSID, Raimunda Telma de Macedo:Adolf Lutz Inst IAL, Pathol Ctr, Sao Paulo, Brazil
· WITKIN, Steven S.:Weill Cornell Med, Dept Obstet & Gynecol, New York, NY USA
· MENDRONE-JUNIOR, Alfredo:FPS HSP, Sao Paulo, Brazil WOS:000455808000017 2-s2.0-85059890059 SAN FRANCISCO USA
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hcfmusp.citation.wos 0 Brasil Estados Unidos

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