Omega-3 multiple effects increasing glucocorticoid-induced muscle atrophy: autophagic, AMPK and UPS mechanisms
Carregando...
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
KAWASAKI, Karine A.
BACELAR, Luana
Citação
PHYSIOLOGICAL REPORTS, v.7, n.1, article ID e13966, 18p, 2019
Resumo
Muscle atrophy occurs in many conditions, including use of glucocorticoids. N-3 (omega-3) is widely consumed due its healthy properties; however, concomitant use with glucocorticoids can increase its side effects. We evaluated the influences of N-3 on glucocorticoid atrophy considering IGF-1, Myostatin, MEK/ERK, AMPK pathways besides the ubiquitin-proteasome system (UPS) and autophagic/lysosomal systems. Sixty animals constituted six groups: CT, N-3 (EPA 100 mg/kg/day for 40 days), DEXA 1.25 (DEXA 1.25 mg/kg/day for 10 days), DEXA 1.25 + N3 (EPA for 40 days + DEXA 1.25 mg/kg/day for the last 10 days), DEXA 2.5 (DEXA 2.5 mg/kg/day for 10 days), and DEXA 2.5 + N3 (EPA for 40 days + DEXA 2.5 mg/kg/day for 10 days). Results: N-3 associated with DEXA increases atrophy (fibers 1 and 2A), FOXO3a, P-SMAD2/3, Atrogin-1/MAFbx (mRNA) expression, and autophagic protein markers (LC3II, LC3II/LC3I, LAMP-1 and acid phosphatase). Additionally, N-3 supplementation alone decreased P-FOXO3a, PGC1-alpha, and type 1 muscle fiber area. Conclusion: N-3 supplementation increases muscle atrophy caused by DEXA in an autophagic, AMPK and UPS process.
Palavras-chave
autophagy, eicosapentaenoic acid, glucocorticoid, IGF-1 pathway, MEK/ERK pathway, muscle atrophy, Myostatin/Smad2/3 pathway, omega-3 fatty acid
Referências
- Andersson A, 2002, AM J CLIN NUTR, V76, P1222
- Aversa Z, 2012, BIOCHEM BIOPH RES CO, V423, P739, DOI 10.1016/j.bbrc.2012.06.029
- Bak DH, 2015, SCI REP-UK, V5, DOI 10.1038/srep15465
- Bodine SC, 2001, NAT CELL BIOL, V3, P1014, DOI 10.1038/ncb1101-1014
- Boonyarom O, 2006, ACTA PHYSIOL, V188, P77, DOI 10.1111/j.1748-1716.2006.01613.x
- Braun T. P., 2015, FRONT PHYSIOL, V6, DOI [10.3389/fphys.2015.00012, DOI 10.3389/FPHYS.2015.00012]
- Britto FA, 2014, AM J PHYSIOL-ENDOC M, V307, pE983, DOI 10.1152/ajpendo.00234.2014
- Bushby K, 2010, LANCET NEUROL, V9, P77, DOI 10.1016/S1474-4422(09)70271-6
- Chen WY, 2012, J NUTR BIOCHEM, V23, P252, DOI 10.1016/j.jnutbio.2010.11.022
- Daviglus ML, 1997, NEW ENGL J MED, V336, P1046, DOI 10.1056/NEJM199704103361502
- Fappi A, 2014, BIOMED RES INT, DOI 10.1155/2014/961438
- Gao B, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.144
- Giron MD, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117520
- Glass DJ, 2003, TRENDS MOL MED, V9, P344, DOI 10.1016/S1471-4914(03)00138-2
- Gupta Anu, 2013, Indian J Endocrinol Metab, V17, P913, DOI 10.4103/2230-8210.117215
- Gwon DH, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102081
- Hasselgren P O, 1999, Curr Opin Clin Nutr Metab Care, V2, P201, DOI 10.1097/00075197-199905000-00002
- Hess TM, 2012, J ANIM SCI, V90, P3023, DOI 10.2527/jas.2011-4412
- Hu SW, 2014, J BIOSCI BIOENG, V117, P457, DOI 10.1016/j.jbiosc.2013.09.005
- Hudson MB, 2014, AM J PHYSIOL-CELL PH, V307, pC314, DOI 10.1152/ajpcell.00395.2013
- Inoue T, 2017, BBA-MOL CELL BIOL L, V1862, P552, DOI 10.1016/j.bbalip.2017.02.010
- Jeng JY, 2009, J AGR FOOD CHEM, V57, P11455, DOI 10.1021/jf902021h
- Jesinkey SR, 2014, J PHARMACOL EXP THER, V351, P663, DOI 10.1124/jpet.114.217380
- Kandarian SC, 2006, MUSCLE NERVE, V33, P155, DOI 10.1002/mus.20442
- Khal J, 2008, BIOCHEM BIOPH RES CO, V375, P238, DOI 10.1016/j.bbrc.2008.08.004
- Kim S, 2018, ONCOL REP, V39, P239, DOI 10.3892/or.2017.6101
- Kolch W, 2000, BIOCHEM J, V351, P289, DOI 10.1042/0264-6021:3510289
- Koskela A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050284
- Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
- Lee Mak-Soon, 2016, Prev Nutr Food Sci, V21, P317, DOI 10.3746/pnf.2016.21.4.317
- Lin J, 2002, NATURE, V418, P797, DOI 10.1038/nature00904
- Liu YL, 2013, J NUTR, V143, P1331, DOI 10.3945/jn.113.176255
- LIVINGSTONE I, 1981, NEUROPATH APPL NEURO, V7, P381, DOI 10.1111/j.1365-2990.1981.tb00240.x
- Ljubicic V, 2011, HUM MOL GENET, V20, P3478, DOI 10.1093/hmg/ddr265
- Long YC, 2011, MOL CELL BIOL, V31, P430, DOI 10.1128/MCB.00983-10
- Martins AR, 2018, J NUTR BIOCHEM, V55, P76, DOI 10.1016/j.jnutbio.2017.11.012
- Marzuca-Nassr GN, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12958
- Matsakas A, 2009, HISTOL HISTOPATHOL, V24, P611, DOI 10.14670/HH-24.611
- Menezes LG, 2007, J APPL PHYSIOL, V102, P698, DOI 10.1152/japplphysiol.01188.2005
- Muldoon MF, 2010, J NUTR, V140, P848, DOI 10.3945/jn.109.119578
- Nader GA, 2005, INT J BIOCHEM CELL B, V37, P1985, DOI 10.1016/j.biocel.2005.02.026
- National Institutes of Health, 2018, N OM 3 FATT AC FACT
- Nicolaides NC, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-71
- Nicolaides NC, 2010, STEROIDS, V75, P1, DOI 10.1016/j.steroids.2009.09.002
- Nishida H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128805
- OGILVIE RW, 1990, STAIN TECHNOL, V65, P231, DOI 10.3109/10520299009105613
- Peng YQ, 2012, MOL CELL BIOCHEM, V367, P165, DOI 10.1007/s11010-012-1329-4
- Qin WP, 2010, BIOCHEM BIOPH RES CO, V403, P473, DOI 10.1016/j.bbrc.2010.11.061
- Pereira RMR, 2011, JOINT BONE SPINE, V78, P41, DOI 10.1016/j.jbspin.2010.02.025
- Rommel C, 1999, SCIENCE, V286, P1738, DOI 10.1126/science.286.5445.1738
- Rossmeisl M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038834
- Salto R, 2014, FEBS LETT, V588, P2246, DOI 10.1016/j.febslet.2014.05.004
- Sandri M, 2006, P NATL ACAD SCI USA, V103, P16260, DOI 10.1073/pnas.0607795103
- Schacke H, 2002, PHARMACOL THERAPEUT, V96, P23, DOI 10.1016/S0163-7258(02)00297-8
- Schakman O, 2013, INT J BIOCHEM CELL B, V45, P2163, DOI 10.1016/j.biocel.2013.05.036
- Schiaffino S, 2013, FEBS J, V280, P4294, DOI 10.1111/febs.12253
- Shen LL, 2017, J LIPID RES, V58, P1808, DOI 10.1194/jlr.M075879
- Su HM, 2010, J NUTR BIOCHEM, V21, P364, DOI 10.1016/j.jnutbio.2009.11.003
- Taouis M, 2002, AM J PHYSIOL-ENDOC M, V282, pE664, DOI 10.1152/ajpendo.00320.2001
- Tisdale MJ, 2007, CLIN NUTR, V26, P161, DOI 10.1016/j.clnu.2006.09.006
- Troncoso R, 2014, CELL CYCLE, V13, P2281, DOI 10.4161/cc.29272
- Tsuchida W, 2017, J CELL PHYSIOL, V232, P650, DOI 10.1002/jcp.25609
- Vannice G, 2014, J ACAD NUTR DIET, V114, P136, DOI 10.1016/j.jand.2013.11.001
- Ventro GJ, 2017, J PEDIATR SURG, V52, P1020, DOI 10.1016/j.jpedsurg.2017.03.031
- Voisin L, 1996, J CLIN INVEST, V97, P1610, DOI 10.1172/JCI118586
- Wang C, 2014, INT J MOL SCI, V15, P15412, DOI 10.3390/ijms150915412
- Wang RX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156225
- Whitehouse AS, 2001, CANCER RES, V61, P3604
- Wu Y, 2010, ENDOCRINOLOGY, V151, P1050, DOI 10.1210/en.2009-0530
- Yao QH, 2015, ONCOL LETT, V9, P2736, DOI 10.3892/ol.2015.3110
- You JS, 2010, APPL PHYSIOL NUTR ME, V35, P310, DOI 10.1139/H10-022
- Zheng B, 2010, FASEB J, V24, P2660, DOI 10.1096/fj.09-151480