Role of serum cholinesterase in patients treated with salvage radical prostatectomy

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP VARTOLOMEI, Mihai Dorin
SORIA, Francesco
ABUFARAJ, Mohammad
I, Pierre Karakiewicz
SHARIAT, Shahrokh F. 2019
dc.identifier.citation UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, v.37, n.2, p.123-129, 2019
dc.identifier.issn 1078-1439
dc.description.abstract Background: Serum cholinesterase (ChE) a serine hydrolase that catalyses the hydrolysis of esters of choline, is involved in cellular proliferation and differentiation, therefore affecting carcinogenesis. The aim of this study was to understand the prognostic role of preoperative serum ChE in patients with radiation-recurrent prostate cancer (CaP) treated with salvage radical prostatectomy (SRP). Material and methods: This retrospective study included 214 patients with radiation-recurrent CaP treated with SRP from January 2007 to December 2015 at 5 academic centers. Patients were considered with abnormal/decreased ChE levels if <5 kU/l. Biochemical recurrence-free and metastases-free (MFS) survival analyses were performed. Results: Median serum ChE level was 6.9 (interquartile range) 6-7.7) kU/l. Serum ChE level (<5 kU/l) was decreased in 25 (11.7%) patients. Decreased serum ChE level was associated with lower body mass index (P = 0.006) and metastasis to lymph nodes (P = 0.004). In multivariable analysis, continuous ChE was an independent predictor of MFS (hazard ratio [HR] 0.48, confidence interval [CI] 0.33-0.71, P < 0.001), overall survival (HR 0.68, CI 0.48-0.96, P = 0.03) and cancer-specific survival (HR 0.41, CI 0.2-0.84, P = 0.01). Serum ChE improved the C-index (by 2.54%) to 87.8% for prediction of overall survival and (by 3%) to 92% for prediction of MFS. Conclusion: Preoperative serum ChE is associated with the development of metastasis in patients with radiation-recurrent CaP who underwent SRP. The biological underpinning of this association with the biological and clinical aggressiveness of CaP needs to be further elucidated.
dc.description.sponsorship · EAU (European Association of Urology)
· OeAD, Austria
dc.language.iso eng
dc.relation.ispartof Urologic Oncology-Seminars and Original Investigations
dc.rights restrictedAccess
dc.subject Radiation-recurrent; Prostate cancer; Salvage radical prostatectomy; Serum cholinesterase; Biomarker
dc.subject.other cancer; men
dc.title Role of serum cholinesterase in patients treated with salvage radical prostatectomy
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE INC LIM/55
dc.identifier.doi 10.1016/j.urolonc.2018.11.013
dc.identifier.pmid 30522902
dc.type.category original article
dc.type.version publishedVersion CHADE, Daher C.:HC:ICESP · VARTOLOMEI, Mihai Dorin:Med Univ Vienna, Dept Urol, Vienna, Austria; Univ Med Pharm Sci & Technol, Dept Cell & Mol Biol, Targu Mures, Romania
· D'ANDREA, David:Med Univ Vienna, Dept Urol, Vienna, Austria
· SORIA, Francesco:Med Univ Vienna, Dept Urol, Vienna, Austria
· KIMURA, Shoji:Med Univ Vienna, Dept Urol, Vienna, Austria; Jikei Univ, Dept Urol, Sch Med, Tokyo, Japan
· FOERSTER, Beat:Med Univ Vienna, Dept Urol, Vienna, Austria; Kantonsspital Winterthur, Dept Urol, Winterthur, Switzerland
· ABUFARAJ, Mohammad:Med Univ Vienna, Dept Urol, Vienna, Austria; Univ Jordan, Jordan Univ Hosp, Dept Special Surg, Div Urol, Amman, Jordan
· MATHIEU, Romain:Med Univ Vienna, Dept Urol, Vienna, Austria; Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria
· MOSCHINI, Marco:Med Univ Vienna, Dept Urol, Vienna, Austria; Rennes Univ Hosp, Dept Urol, Rennes, France; Luzerner Kantonsspital, Klin Urol, Luzern, Switzerland; Univ Vita Salute San Raffaele, Urol Res Inst, San Raffaele Sci Inst, Dept Urol, Milan, Italy
· ROUPRET, Morgan:Sorbonne Univ, Paris, France
· BRIGANTI, Alberto:Univ Vita Salute San Raffaele, Urol Res Inst, San Raffaele Sci Inst, Dept Urol, Milan, Italy
· I, Pierre Karakiewicz:Univ Montreal, Dept Urol, Montreal, PQ, Canada
· SHARIAT, Shahrokh F.:Med Univ Vienna, Dept Urol, Vienna, Austria; Karl Landsteiner Inst Urol & Androl, Vienna, Austria; Univ Texas Southwestern Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA; Weill Cornell Med Coll, Dept Urol, New York, NY 10065 USA WOS:000454818000004 2-s2.0-85057561233 NEW YORK USA
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dc.description.index MEDLINE
dc.identifier.eissn 1873-2496
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0 Brasil Romênia Áustria Japão Suíça Jordânia Itália França Canadá Estados Unidos

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