Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/31034
Title: | Imatinib-induced fulminant liver failure in chronic myeloid leukemia: Role of liver transplant and second-generation tyrosine kinase inhibitors: A case report |
Authors: | NACIF, L. S.; WAISBERG, D. R.; PINHEIRO, R. S.; LIMA, F. R.; ROCHA-SANTOS, V.; ANDRAUS, W.; D'ALBUQUERQUE, L. C. |
Citation: | JOURNAL OF MEDICAL CASE REPORTS, v.12, n.1, article ID 63, p, 2018 |
Abstract: | Background: There is a worldwide problem of acute liver failure and mortality associated with remaining on the waiting for a liver transplant. In this study, we highlight results published in recent years by leading transplant centers in evaluating imatinib-induced acute liver failure in chronic myeloid leukemia and follow-up in liver transplantation. Case presentation: A 36-year-old brown-skinned woman (mixed Brazilian race) diagnosed 1 year earlier with chronic myeloid leukemia was started after delivery of a baby and continued for 6 months with imatinib mesylate (selective inhibitor of Bcr-Abl tyrosine kinase), which induced liver failure. We conducted a literature review using the PubMed database for articles published through September 2017, and we demonstrate a role of liver transplant in this situation for imatinib-induced liver failure. We report previously published results and a successful liver transplant after acute liver failure due to imatinib-induced in chronic myeloid leukemia treatment. Conclusions: We report a case of a successful liver transplant after acute liver failure resulting from imatinib-induced chronic myeloid leukemia treatment. The literature reveals the importance of prompt acute liver failure diagnosis and treatment with liver transplant in selected cases. © 2018 The Author(s). |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/37 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_NACIF_Imatinibinduced_fulminant_liver_failure_in_chronic_myeloid_leukemia_2018.PDF | publishedVersion (English) | 3.48 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.