Altered cortical excitability in persistent idiopathic facial pain

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art_GALHARDONI_Altered_cortical_excitability_in_persistent_idiopathic_facial_pain_2019.PDF (390.19 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS LTD
Autores
Citação
CEPHALALGIA, v.39, n.2, p.219-228, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction Persistent idiopathic facial pain is a refractory and disabling condition of unknown mechanism and etiology. It has been suggested that persistent idiopathic facial pain patients have not only peripheral generators of pain, but also central nervous system changes that would contribute to the persistence of symptoms. We hypothesized that persistent idiopathic facial pain would have changes in brain cortical excitability as measured by transcranial magnetic stimulation compared to healthy controls. Methods Twenty-nine persistent idiopathic facial pain patients were compared to age- and sex-matched healthy controls and underwent cortical excitability measurements by transcranial magnetic stimulation applied to the cortical representation of the masseter muscle of both hemispheres. Single-pulse stimulation was used to measure the resting motor threshold and suprathreshold motor-evoked potentials. Paired-pulse stimulation was used to assess short intracortical inhibition and intracortical facilitation. Clinical pain and associated symptoms were assessed with validated tools. Results Spontaneous pain was found in 27 (93.1%) and provoked pain was found in two (6.9%) persistent idiopathic facial pain patients. The motor-evoked potentials at 120% and 140% were significantly lower for both hemispheres compared to controls. Persistent idiopathic facial pain patients had lower short-interval intracortical inhibition compared with controls. These changes were correlated with some aspects of quality of life, and higher mood symptoms. These neurophysiological alterations were not influenced by analgesic medication, as similar changes were observed in patients with or without central-acting drugs. Conclusions Persistent idiopathic facial pain is associated with changes in intracortical modulation involving GABAergic mechanisms, which may be related to certain aspects of the pathophysiology of this chronic pain condition. Trial registration: NTC01746355.
Palavras-chave
Persistent idiopathic facial pain, cortical excitability, chronic pain, neuropathic pain, transcranial magnetic stimulation, atypical facial pain
URI
https://observatorio.fm.usp.br/handle/OPI/31089
Referências
  1. Agostoni E, 2005, NEUROL SCI, V26, pS71, DOI 10.1007/s10072-005-0412-y
  2. Bes A, 2013, CEPHALALGIA, V33, P629, DOI 10.1177/0333102413485658
  3. Bouhassira D, 2011, PAIN, V152, pS74, DOI 10.1016/j.pain.2010.11.027
  4. Ciconelli R, 2004, REV BRAS REUMATOL, V39, P143
  5. Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
  6. Cueva AS, 2016, NEUROPHYSIOL CLIN, V46, P43, DOI 10.1016/j.neucli.2015.12.003
  7. de Andrade DC, 2017, PAIN, V158, P1473, DOI 10.1097/j.pain.0000000000000932
  8. de Andrade DC, 2014, PAIN, V155, P598, DOI 10.1016/j.pain.2013.12.022
  9. de Andrade DC, 2011, HEALTH QUAL LIFE OUT, V9, DOI 10.1186/1477-7525-9-107
  10. de Andrade DC, 2011, PAIN, V152, P320, DOI 10.1016/j.pain.2010.10.032
  11. de Siqueira JTT, 2004, ARQ NEURO-PSIQUIAT, V62, P988, DOI 10.1590/S0004-282X2004000600011
  12. Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
  13. Ferreira KA, 2011, SUPPORT CARE CANCER, V19, P505, DOI 10.1007/s00520-010-0844-7
  14. Garcia O, 1999, P 9 WORLD C PAIN 22
  15. Graff-Radford SB, 2009, NEUROLOGIST, V15, P171, DOI 10.1097/NRL.0b013e31819827d8
  16. Groppa S, 2012, CLIN NEUROPHYSIOL, V123, P858, DOI 10.1016/j.clinph.2012.01.010
  17. Hashmi JA, 2013, BRAIN, V136, P2751, DOI 10.1093/brain/awt211
  18. Huang H, 2014, NEUROSCI LETT, V558, P82, DOI 10.1016/j.neulet.2013.11.014
  19. Koratkar HPJ, 2008, NW DENT, V87, P37
  20. Lefaucheur JP, 2006, NEUROLOGY, V67, P1568, DOI 10.1212/01.wnl.0000242731.10074.3c
  21. Lefaucheur JP, 2006, NEUROPHYSIOL CLIN, V36, P117, DOI 10.1016/j.neurcli.2006.08.002
  22. Lefaucheur JP, 2006, NEUROLOGY, V67, P1998, DOI 10.1212/01.wnl.0000247138.85330.88
  23. List T, 2007, J OROFAC PAIN, V21, P89
  24. Manzoni GC, 2005, NEUROL SCI, V26, pS65, DOI 10.1007/s10072-005-0410-0
  25. Marcolino José Álvaro Marques, 2007, Rev. Bras. Anestesiol., V57, P52, DOI 10.1590/S0034-70942007000100006
  26. Nobrega JCM, 2007, ARQ NEURO-PSIQUIAT, V65, P256, DOI 10.1590/S0004-282X2007000200013
  27. Melis Marcello, 2007, J Contemp Dent Pract, V8, P81
  28. Mhalla A, 2010, PAIN, V149, P495, DOI 10.1016/j.pain.2010.03.009
  29. PFAFFENRATH V, 1993, CEPHALALGIA, V13, P84, DOI 10.1177/0333102493013S1218
  30. Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
  31. ROSSINI PM, 1994, ELECTROEN CLIN NEURO, V91, P79, DOI 10.1016/0013-4694(94)90029-9
  32. Santos JG, 2010, J PAIN, V11, P484, DOI 10.1016/j.jpain.2009.09.014
  33. Ferreira KAS, 2013, PAIN MANAG NURS, V14, P210, DOI 10.1016/j.pmn.2011.04.006
  34. Schwenkreis P, 2003, NEUROLOGY, V61, P515, DOI 10.1212/WNL.61.4.515
  35. Silberstein SD, 2004, CEPHALALGIA, V24, P2, DOI 10.1111/j.1468-2982.2004.00892.x
  36. Sullivan MJL, 1995, PSYCHOL ASSESSMENT, V7, P524, DOI 10.1037/1040-3590.7.4.524
  37. Woda A, 2003, J DENT RES, V82, P764, DOI 10.1177/154405910308201001
  38. Woda A, 2000, J OROFAC PAIN, V14, P196
  39. Woda A, 2007, J OROFAC PAIN, V22, P257
  40. Woda A, 2009, J OROFAC PAIN, V23, P89
  41. Ziemann U, 2004, CLIN NEUROPHYSIOL, V115, P1717, DOI 10.1016/j.clinph.2004.03.006
  42. ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/26
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