Epicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America

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art_LIMA-MARTINEZ_Epicardial_adipose_tissue_thickness_and_type_2_diabetes_2019.PDF (662.82 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2019
Editora
ELSEVIER SCIENCE BV
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
LIMA-MARTINEZ, Marcos M.
COLMENARES, Leomar
CAMPANELLI, Yanei
PAOLI, Mariela
RODNEY, Marianela
IACOBELLIS, Gianluca
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS, v.31, n.1, p.15-22, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The Finnish Diabetes Risk Score (FINDRISC) is a tool to predict 10-year risk of type 2 diabetes mellitus (T2DM), and visceral adiposity is associated with higher cardio-metabolic risk. The objective of the study was to assess the relationship of epicardial adipose tissue (EAT) thickness with T2DM risk according to the FINDRISC tool. Methods: The study was conducted in Ciudad Bolivar, Venezuela, and included 55 subjects of whom 37 (67.3%) were women and 18 (32.7%) men with ages between 18 and 75 years. A record was made of weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, baseline insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and EAT thickness. The FINDRISC tool, with WC cut-off points modified for Latin America (LA-FINDRISC) was used. Results: BMI, WC, plasma insulin concentration, HOMA-IR index, and EAT thickness were higher (P < 0.0001) in the high-risk group compared to subjects in the low-moderate risk group according to the LA-FINDRISC. LA-FINDRISC was positively correlated with BMI (r=0.513; P=0.0001), WC (r=0.524; P=0.0001), fasting blood glucose (r=0.396; P=0.003); baseline plasma insulin (r=0.483; P=0.0001); HOMA-IR index (r=0.545; P=.0.0001);and EAT thickness (r=0.702; P=0.0001). The multivariate regression analysis showed that fasting blood glucose (P=0.023) and EAT thickness (P=0.007) remained independently associated with high T2DM risk. Conclusions: LA-FINDRISC was associated with EAT thickness and insulin resistance markers. Both were independently and directly associated with high risk for diabetes in the LA-FINDRISC category.
Palavras-chave
FINDRISC, Diabetes, Epicardial fat, Epicardial adipose tissue
URI
https://observatorio.fm.usp.br/handle/OPI/31127
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03