Does the RYGB common limb length influence hypertension remission and cardiometabolic risk factors? Data from the GATEWAY trial

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art_SCHIAVON_Does_the_RYGB_common_limb_length_influence_hypertension_2019.PDF (660.46 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
SCHIAVON, Carlos Aurelio
SANTOS, Renato Nakagawa
SANTUCCI, Eliana Vieira
NOUJAIM, Patricia Malvina
CAVALCANTI, Alexandre Biasi
Citação
SURGERY FOR OBESITY AND RELATED DISEASES, v.15, n.2, p.211-217, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Although Roux-en-Y gastric bypass (RYGB) results in significant weight loss and cardiometabolic risk factors improvements; there is no consensus whether limb lengths may influence these results. Objective: To evaluate the correlations between the common limb length (CLL) and hypertension remission rate, cardiometabolic risk factors, and nutritional parameters after RYGB. Settings: Private Hospital, Brazil. Methods: GATEWAY is a randomized trial designed to evaluate the efficacy of RYGB on hypertension improvement and other cardiometabolic risk factors in patients with grade I and II obesity compared with medical therapy. The follow-up was 1 year. We measured the entire bowel in all patients and used a 150-cm alimentary limb and a 100-cm biliopancreatic limb. Univariate logistic regression was used to estimate the relationship between CLL and hypertension remission. Pearson and Spearman correlation were used to evaluate the correlation between the CLL and the percentage changes of cardiometabolic risk factors and nutritional parameters. Results: From 100 randomized patients, 45 were submitted to RYGB and completed the follow-up. Mean CLL was 466.3 +/- 86.4 cm. Of patients, 55.6% from the RYGB group showed remission of hypertension. CLL length was not significantly associated with hypertension remission (odds ratio [95% confidence interval] for 50 units increase in CLL:.97 [.68; 1.38], P=.88). Consistently, we found no correlations between CLL and all changes in cardiometabolic risk factors and nutritional parameters. Conclusions: In a proximal RYGB, CLL does not influence hypertension remission, cardiometabolic risk factors, and nutritional parameters.
Palavras-chave
Gastric bypass, Limb lengths, Hypertension, Cardiometabolic risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/31622
Referências
  1. Adams ST, 2013, POSTGRAD MED J, V89, P411, DOI 10.1136/postgradmedj-2012-131310
  2. Adams TD, 2017, NEW ENGL J MED, V377, P1143, DOI 10.1056/NEJMoa1700459
  3. BROLIN RE, 1992, ANN SURG, V215, P387, DOI 10.1097/00000658-199204000-00014
  4. Buchwald H, 2017, OBES SURG, V27, P2293, DOI 10.1007/s11695-017-2658-x
  5. Choban PS, 2002, OBES SURG, V12, P540, DOI 10.1381/096089202762252316
  6. Christou NV, 2006, ANN SURG, V244, P734, DOI 10.1097/01.sla.0000217592.04061.d5
  7. Courcoulas AP, 2013, JAMA-J AM MED ASSOC, V310, P2416, DOI 10.1001/jama.2013.280928
  8. Ghiassi S, 2018, SURG OBES RELAT DIS, V14, P554, DOI 10.1016/j.soard.2018.01.004
  9. Gleysteen JJ, 2009, SURG OBES RELAT DIS, V5, P242, DOI 10.1016/j.soard.2008.08.005
  10. Hess DS, 2003, OBES SURG, V13, P966, DOI 10.1381/096089203322618885
  11. Livhits M, 2012, OBES SURG, V22, P70, DOI 10.1007/s11695-011-0472-4
  12. MacLean LD, 2001, J GASTROINTEST SURG, V5, P525, DOI 10.1016/S1091-255X(01)80091-3
  13. Madan AK, 2008, SURG OBES RELAT DIS, V4, P166, DOI 10.1016/j.soard.2007.08.006
  14. Mahawar KK, 2016, OBES SURG, V26, P660, DOI 10.1007/s11695-016-2050-2
  15. Mehaffey JH, 2016, ANN SURG, V264, P121, DOI 10.1097/SLA.0000000000001544
  16. Michell AR, 2008, ANNU REV PHYSIOL, V70, P379, DOI 10.1146/annurev.physiol.69.040705.141330
  17. Murad AJ, 2018, OBES SURG, V28, P599, DOI 10.1007/s11695-017-2933-x
  18. Navez B, 2016, OBES SURG, V26, P1705, DOI 10.1007/s11695-015-1992-0
  19. Orci L, 2011, OBES SURG, V21, P797, DOI 10.1007/s11695-011-0409-y
  20. Pinheiro JS, 2008, SURG OBES RELAT DIS, V4, P521, DOI 10.1016/j.soard.2007.12.016
  21. Rawlins ML, 2011, SURG OBES RELAT DIS, V7, P45, DOI 10.1016/j.soard.2010.08.013
  22. Savassi-Rocha AL, 2008, OBES SURG, V18, P1364, DOI 10.1007/s11695-008-9475-1
  23. Schiavon CA, 2018, CIRCULATION, V137, P1132, DOI 10.1161/CIRCULATIONAHA.117.032130
  24. Schiavon CA, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0598-x
  25. Schiavon CA, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005702
  26. Topart PA, 2015, SURG OBES RELAT DIS, V11, P965, DOI 10.1016/j.soard.2015.01.015
  27. 2016, JAMA SURG, V151, P1146, DOI 10.1001/JAMASURG.2016.2798

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/63
Artigos e Materiais de Revistas Científicas - ODS/03