Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

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art_BENTLEY_Multiancestry_genomewide_genesmoking_interaction_study_of_387272_individuals_2019.PDF (1.67 MB)
Citações na Scopus
75
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
BENTLEY, Amy R.
SUNG, Yun J.
BROWN, Michael R.
WINKLER, Thomas W.
KRAJA, Aldi T.
NTALLA, Ioanna
SCHWANDER, Karen
I, Daniel Chasman
LIM, Elise
DENG, Xuan
Citação
NATURE GENETICS, v.51, n.4, p.636-+, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
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URI
https://observatorio.fm.usp.br/handle/OPI/31639
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13