Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center
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Citações na Scopus
11
Tipo de produção
article
Data de publicação
2019
Editora
SPRINGER
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Lymphangioleiomyomatosis Angiomyol
Editores
Coordenadores
Organizadores
Citação
LUNG, v.197, n.2, p.139-146, 2019
Resumo
IntroductionSerum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement.MethodsWe conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers. Clinical and functional parameters were assessed and correlated with their respective serum VEGF-D levels.ResultsOne hundred and four patients were included in the analysis. Serum VEGF-D levels were higher in LAM patients compared to healthy controls: 796 (404-1588) versus 162 (117-232)pg/mL, respectively (p<0.001). Patients with tuberous sclerosis complex-LAM, TSC-LAM (20%), had higher levels of VEGF-D when compared to patients with sporadic LAM (80%) [1005 (641-2732) vs. 772 (370-1383), p=0.05]. Serum VEGF-D levels were weakly correlated with DLCO (r=-0.26, p=0.001) and lymphatic involvement was more frequent in those with serum VEGF-D levels equal or above 800pg/mL (35% vs. 13%, p=0.02).ConclusionsIn LAM, serum VEGF-D is weakly associated with lung function impairment and strongly associated with lymphatic involvement. VEGF-D is validated for use in Brazilian patients with LAM whose characteristics must be accounted for when evaluating their serum VEGF-D levels.
Palavras-chave
Interstitial lung disease, Lymphangioleiomyomatosis, Pulmonary function tests, Vascular endothelial growth factor
Referências
- Baldi BG, 2014, LUNG, V192, P967, DOI 10.1007/s00408-014-9641-2
- Carsillo T, 2000, P NATL ACAD SCI USA, V97, P6085, DOI 10.1073/pnas.97.11.6085
- Chang WYC, 2012, RESP RES, V13, DOI 10.1186/1465-9921-13-34
- Crapo RO, 2002, AM J RESP CRIT CARE, V166, P111, DOI 10.1164/rccm.166/1/111
- Freitas CSG, 2017, ORPHANET J RARE DIS, V12, DOI 10.1186/s13023-017-0626-0
- Glasgow CG, 2009, CHEST, V135, P1293, DOI 10.1378/chest.08-1160
- Glassberg MK, 2004, CLIN CHEST MED, V25, P573, DOI 10.1016/j.ccm.2004.05.003
- Baldi BG, 2014, SARCOIDOSIS VASC DIF, V31, P129
- Gupta N, 2017, AM J RESP CRIT CARE, V196, P1337, DOI 10.1164/rccm.201709-1965ST
- Johnson SR, 2010, EUR RESPIR J, V35, P14, DOI 10.1183/09031936.00076209
- Kumasaka T, 2004, AM J SURG PATHOL, V28, P1007, DOI 10.1097/01.pas.0000126859.70814.6d
- MacIntyre N, 2005, EUR RESPIR J, V26, P720, DOI 10.1183/09031936.05.00034905
- McCormack FX, 2016, AM J RESP CRIT CARE, V194, P748, DOI 10.1164/rccm.201607-1384ST
- Miller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805
- Neder JA, 1999, BRAZ J MED BIOL RES, V32, P729, DOI 10.1590/S0100-879X1999000600008
- Pereira Carlos Alberto de Castro, 2007, J. bras. pneumol., V33, P397, DOI 10.1590/S1806-37132007000400008
- Radzikowska E, 2015, RESP MED, V109, P1469, DOI 10.1016/j.rmed.2015.09.005
- Radzikowska E, 2013, POL ARCH MED WEWN, V123, P533, DOI 10.20452/pamw.1927
- Ryu JH, 2006, AM J RESP CRIT CARE, V173, P105, DOI 10.1164/rccm.200409-1298OC
- Sengupta S, 2010, MOL CELL, V40, P310, DOI 10.1016/j.molcel.2010.09.026
- Seyama Kuniaki, 2006, Lymphatic Research and Biology, V4, P143, DOI 10.1089/lrb.2006.4.143
- Taveira-DaSilva AM, 2018, CHEST, V153, P124, DOI 10.1016/j.chest.2017.05.012
- do Nascimento ECT, 2018, RESP RES, V19, DOI 10.1186/s12931-018-0797-9
- Wanger J, 2005, EUR RESPIR J, V26, P511, DOI 10.1183/09031936.05.00035005
- Xu KF, 2013, RESP MED, V107, P263, DOI 10.1016/j.rmed.2012.10.006
- Young LR, 2008, NEW ENGL J MED, V358, P199, DOI 10.1056/NEJMc0707517
- Young LR, 2013, LANCET RESP MED, V1, P445, DOI 10.1016/S2213-2600(13)70090-0
- Young LR, 2010, CHEST, V138, P674, DOI 10.1378/chest.10-0573
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Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - FM/MCM
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Artigos e Materiais de Revistas Científicas - LIM/09
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Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
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Artigos e Materiais de Revistas Científicas - LIM/09