Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load
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Citações na Scopus
13
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
ALKAN, E.
STERR, A.
SCHANTZ, M. von
POMPEIA, S.
Citação
SCIENTIFIC REPORTS, v.9, article ID 4356, 9p, 2019
Resumo
Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N=103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.
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Referências
- Akbaraly TN, 2010, DIABETES CARE, V33, P84, DOI 10.2337/dc09-1218
- Alfaro FJ, 2016, J NEUROL, V263, P2505, DOI 10.1007/s00415-016-8292-z
- Aribisala BS, 2014, HYPERTENSION, V63, P1011, DOI 10.1161/HYPERTENSIONAHA.113.02735
- Assuncao N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194990
- Banks WA, 2018, INT J OBESITY, V42, P391, DOI 10.1038/ijo.2017.231
- Basile AM, 2006, CEREBROVASC DIS, V21, P315, DOI 10.1159/000091536
- Bertolucci PHF, 2001, ARQ NEURO-PSIQUIAT, V59, P532, DOI 10.1590/S0004-282X2001000400009
- Bokura H, 2010, DEMENT GERIATR COGN, V30, P479, DOI 10.1159/000322057
- Bolandzadeh N, 2012, BMC NEUROL, V12, DOI 10.1186/1471-2377-12-126
- Boyle PA, 2016, ANN CLIN TRANSL NEUR, V3, P791, DOI 10.1002/acn3.343
- Cherbuin N, 2015, J NEUROL SCI, V357, pE44, DOI 10.1016/j.jns.2015.08.189
- Choi HS, 2009, CLIN ENDOCRINOL, V71, P184, DOI 10.1111/j.1365-2265.2008.03444.x
- de Oliveira CM, 2008, BMC MED GENET, V9, DOI 10.1186/1471-2350-9-32
- Debette S, 2010, BRIT MED J, V341, DOI 10.1136/bmj.c3666
- Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
- Dufouil C, 2001, NEUROLOGY, V56, P921, DOI 10.1212/WNL.56.7.921
- Egan KJ, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011598
- Egger C, 2017, NEUROIMAGE-CLIN, V13, P264, DOI 10.1016/j.nicl.2016.11.020
- Erten-Lyons D, 2013, NEUROLOGY, V81, P977, DOI 10.1212/WNL.0b013e3182a43e45
- Farfel JM, 2013, NEUROLOGY, V81, P650, DOI 10.1212/WNL.0b013e3182a08f1b
- Firbank MJ, 2007, J NEUROL, V254, P713, DOI 10.1007/s00415-006-0238-4
- Griffanti L, 2018, NEUROIMAGE, V170, P174, DOI 10.1016/j.neuroimage.2017.03.024
- Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
- Hopkins RO, 2006, J NEUROIMAGING, V16, P243, DOI 10.1111/j.1552-6569.2006.00047.x
- Iadecola C, 2008, CELL METAB, V7, P476, DOI 10.1016/j.cmet.2008.03.010
- Iadecola C, 2016, HYPERTENSION, V68, pE67, DOI 10.1161/HYP.0000000000000053
- Iadecola C, 2009, STROKE, V40, pS40, DOI 10.1161/STROKEAHA.108.533638
- Immink RV, 2004, CIRCULATION, V110, P2241, DOI 10.1161/01.CIR.0000144472.08647.40
- Kloppenborg RP, 2014, NEUROLOGY, V82, P2127, DOI 10.1212/WNL.0000000000000505
- Laudisio A, 2008, CLIN NUTR, V27, P747, DOI 10.1016/j.clnu.2008.07.001
- Livny A, 2016, DIABETES CARE, V39, P1056, DOI 10.2337/dc15-2331
- Lockhart SN, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00056
- Maldjian JA, 2013, AM J NEURORADIOL, V34, P2265, DOI 10.3174/ajnr.A3590
- Murray AD, 2005, RADIOLOGY, V237, P251, DOI 10.1148/radiol.2371041496
- Pantoni L, 2010, LANCET NEUROL, V9, P689, DOI 10.1016/S1474-4422(10)70104-6
- Park K, 2007, NEUROLOGY, V69, P974, DOI 10.1212/01.wnl.0000266562.54684.bf
- Portet Florence, 2012, Alzheimers Dement, V8, pS88, DOI 10.1016/j.jalz.2011.11.007
- Prins ND, 2015, NAT REV NEUROL, V11, DOI 10.1038/nrneurol.2015.10
- Reuter-Lorenz PA, 2014, NEUROPSYCHOL REV, V24, P355, DOI 10.1007/s11065-014-9270-9
- Rizvi B, 2018, NEUROBIOL AGING, V64, P25, DOI 10.1016/j.neurobiolaging.2017.12.006
- Ruud J, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15259
- Ryu WS, 2014, STROKE, V45, P3567, DOI 10.1161/STROKEAHA.114.006662
- Sachdev P, 2007, NEUROLOGY, V68, P214, DOI 10.1212/01.wnl.0000251302.55202.73
- Sala M, 2014, DIABETES CARE, V37, P493, DOI 10.2337/dc13-1160
- Schmidt P, 2012, NEUROIMAGE, V59, P3774, DOI 10.1016/j.neuroimage.2011.11.032
- Schneider AL, 2017, DIABETES CARE, V40, P1514, DOI 10.2337/dc17-1185
- Schuur M, 2010, EUR J EPIDEMIOL, V25, P561, DOI 10.1007/s10654-010-9476-y
- Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
- Sims RC, 2014, DIABETIC MED, V31, P691, DOI 10.1111/dme.12385
- Stern Y, 2012, LANCET NEUROL, V11, P1006, DOI 10.1016/S1474-4422(12)70191-6
- Swardfager W, 2018, NEUROLOGY, V90, pE673, DOI 10.1212/WNL.0000000000004983
- Tournoy J, 2010, DIABETES-METAB RES, V26, P668, DOI 10.1002/dmrr.1144
- van den Berg E, 2007, NEUROLOGY, V69, P979, DOI 10.1212/01.wnl.0000271381.30143.75
- VANSWIETEN JC, 1991, BRAIN, V114, P761
- Verhaaren BFJ, 2013, HYPERTENSION, V61, P1354, DOI 10.1161/HYPERTENSIONAHA.111.00430
- Viscogliosi G, 2015, PSYCHIAT CLIN NEUROS, V69, P620, DOI 10.1111/pcn.12296
- Yin ZX, 2012, AGE AGEING, V41, P600, DOI 10.1093/ageing/afs033
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - LIM/23