Topography of C-11-Pittsburgh compound B uptake in Alzheimer's disease: a voxel-based investigation of cortical and white matter regions
Carregando...
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
ASSOC BRASILEIRA PSIQUIATRIA
Citação
REVISTA BRASILEIRA DE PSIQUIATRIA, v.41, n.2, p.101-111, 2019
Resumo
Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (C-11-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer's disease (AD), and explore possible group differences in C-11-PIB binding to white matter. Methods: C-11-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM). Results: Cerebellar normalization showed higher C-11-PIB uptake in the AD group relative to controls throughout the cerebral cortex, involving the lateral temporal, orbitofrontal, and superior parietal cortices. With global uptake normalization, greatest cortical binding was detected in the orbitofrontal cortex; decreased C-11-PIB uptake in white matter was found in the posterior hippocampal region, corpus callosum, pons, and internal capsule. Conclusion: The present case-control voxelwise C-11-PIB PET comparison highlighted the regional distribution of amyloid deposition in the cerebral cortex of mildly demented AD patients. Tracer uptake was highest in the orbitofrontal cortex. Decreased C-11-PIB uptake in white-matter regions in this patient population may be a marker of white-matter damage in AD.
Palavras-chave
Amyloid PET imaging, Alzheimer's disease, statistical parametric mapping
Referências
- Aalto S, 2009, EUR J NUCL MED MOL I, V36, P1651, DOI 10.1007/s00259-009-1174-1
- Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
- Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
- Benzinger TLS, 2013, P NATL ACAD SCI USA, V110, pE4502, DOI 10.1073/pnas.1317918110
- BLESSED G, 1968, BRIT J PSYCHIAT, V114, P797, DOI 10.1192/bjp.114.512.797
- Borghammer P, 2009, NEUROIMAGE, V46, P981, DOI 10.1016/j.neuroimage.2009.03.021
- Brucki SMD, 2003, ARQ NEURO-PSIQUIAT, V61, P777, DOI 10.1590/S0004-282X2003000500014
- Buckner RL, 2012, NEUROIMAGE, V62, P1137, DOI 10.1016/j.neuroimage.2011.10.035
- Del-Ben Cristina Marta, 2001, Revista Brasileira de Psiquiatria, V23, P156, DOI 10.1590/S1516-44462001000300008
- Drzezga A, 2008, NEUROIMAGE, V39, P619, DOI 10.1016/j.neuroimage.2007.09.020
- Dukart J, 2010, NEUROIMAGE, V49, P1490, DOI 10.1016/j.neuroimage.2009.09.017
- Duran FLS, 2007, CLINICS, V62, P377, DOI 10.1590/S1807-59322007000400002
- Edison P, 2013, NEUROIMAGE, V70, P423, DOI 10.1016/j.neuroimage.2012.12.014
- Fjell AM, 2014, PROG NEUROBIOL, V117, P20, DOI 10.1016/j.pneurobio.2014.02.004
- Formaglio M, 2011, J NEUROL, V258, P1841, DOI 10.1007/s00415-011-6030-0
- Gomperts SN, 2008, NEUROLOGY, V71, P903, DOI 10.1212/01.wnl.0000326146.60732.d6
- Griebe M, 2011, J NEUROL, V258, P1451, DOI 10.1007/s00415-011-5956-6
- Maia ALG, 2006, ARQ NEURO-PSIQUIAT, V64, P485, DOI 10.1590/S0004-282X2006000300025
- Grimmer T, 2009, BIOL PSYCHIAT, V65, P927, DOI 10.1016/j.biopsych.2009.01.027
- Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
- Hosokawa C, 2015, ANN NUCL MED, V29, P164, DOI 10.1007/s12149-014-0924-8
- Jack CR, 2018, ALZHEIMERS DEMENT, V14, P535, DOI 10.1016/j.jalz.2018.02.018
- Jack CR, 2017, ALZHEIMERS DEMENT, V13, P205, DOI 10.1016/j.jalz.2016.08.005
- Klunk WE, 2004, ANN NEUROL, V55, P306, DOI 10.1002/ana.20009
- Klunk WE, 2015, ALZHEIMERS DEMENT, V11, P1, DOI 10.1016/j.jalz.2014.07.003
- Kuntzelmann A, 2013, NEUROSCI LETT, V534, P12, DOI 10.1016/j.neulet.2012.11.026
- Lopresti BJ, 2005, J NUCL MED, V46, P1959
- Matsubara K, 2016, NEUROIMAGE, V143, P316, DOI 10.1016/j.neuroimage.2016.09.028
- McKhann GM, 2011, ALZHEIMERS DEMENT, V7, P263, DOI 10.1016/j.jalz.2011.03.005
- Meltzer CC, 2000, J NUCL MED, V41, P1842
- Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
- Mormino EC, 2014, JAMA NEUROL, V71, P1379, DOI 10.1001/jamaneurol.2014.2031
- Mosconi L, 2008, J NUCL MED, V49, P390, DOI 10.2967/jnumed.107.045385
- Pike KE, 2007, BRAIN, V130, P2837, DOI 10.1093/brain/awm238
- Price JC, 2005, J CEREBR BLOOD F MET, V25, P1528, DOI 10.1038/sj.jcbfm.9600146
- Quarantelli M, 2004, J NUCL MED, V45, P192
- Radanovic M, 2013, EXPERT REV NEUROTHER, V13, P483, DOI [10.1586/ERN.13.45, 10.1586/ern.13.45]
- Rieckmann A, 2016, NEUROBIOL AGING, V42, P177, DOI 10.1016/j.neurobiolaging.2016.03.016
- Sakono M, 2010, FEBS J, V277, P1348, DOI 10.1111/j.1742-4658.2010.07568.x
- Sepulcre J, 2013, BRAIN, V136, P2239, DOI 10.1093/brain/awt146
- Shin J, 2010, NEUROIMAGE, V52, P488, DOI 10.1016/j.neuroimage.2010.04.013
- Stankoff B, 2011, ANN NEUROL, V69, P673, DOI 10.1002/ana.22320
- Talairach J, 1988, COPLANAR STEREOTAXIC
- Thomas BA, 2011, EUR J NUCL MED MOL I, V38, P1104, DOI 10.1007/s00259-011-1745-9
- Tom SE, 2015, AM J PUBLIC HEALTH, V105, P408, DOI 10.2105/AJPH.2014.301935
- Toussaint PJ, 2012, NEUROIMAGE, V63, P936, DOI 10.1016/j.neuroimage.2012.03.091
- Wang PN, 2012, J ALZHEIMERS DIS, V30, P423, DOI 10.3233/JAD-2012-111304
- Yamane T, 2017, EUR J NUCL MED MOL I, V44, P850, DOI 10.1007/s00259-016-3591-2
- Yasuno F, 2015, INT J GERIATR PSYCH, V30, P919, DOI 10.1002/gps.4235
- Zhang Y, 2007, NEUROLOGY, V68, P13, DOI 10.1212/01.wnl.0000250326.77323.01
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15