THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
COLEGIO BRASILEIRO CIRURGIA DIGESTIVA-CBCD
Autores
SOLER, Wangles Vasconcellos
D'ALBUQUERQUE, Eugenia Machado Carneiro
CAPELHUCHNICK, Peretz
LANCELOTTI, Carmem Penteado
Citação
ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY, v.32, n.1, article ID UNSP e1417, 5p, 2019
Resumo
Background: Short bowel syndrome is a harmful condition that needs experimental research. Aim: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. Method: Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30""' postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. Results: Group I and II presented progressive loss of weight. in Group I was observed diarrhea, perinea! hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. in Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. Conclusion: This short bowel syndrome model is relevant and achieve 100% of survival. Animal's weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve.
Palavras-chave
Short bowel syndrome, Protein malnutrition, Intestinal mucosa
Referências
- ALLEN AC, 1971, AM J GASTROENTEROL, V55, P347
- Barra Ângela Aparecida, 2012, Rev. Col. Bras. Cir., V39, P521, DOI 10.1590/S0100-69912012000600013
- Collins J B, 1995, Semin Pediatr Surg, V4, P60
- Galvao FHF, 2012, MICROSURG, V32, P77, DOI 10.1002/micr.20958
- Galvao FHF, 2005, TRANSPLANTATION, V80, P1522, DOI 10.1097/01.tp.000018448.86704.c8
- Goulet O, 1998, NUTRITION, V14, P784, DOI 10.1016/S0899-9007(98)00084-7
- HANSON WR, 1977, GASTROENTEROLOGY, V72, P692
- Brito MVH, 2017, ABCD-ARQ BRAS CIR DI, V30, P27, DOI 10.1590/0102-6720201700010008
- Jeejeebhoy KN, 2006, GASTROENTEROLOGY, V130, pS60, DOI 10.1053/j.gastro.2005.10.065
- LOPES Lilian Pinheiro, 2018, ABCD, arq. bras. cir. dig., V31, pe1359, DOI 10.1590/0102-672020180001e1359
- Mazaki T, ENTERAL VERSUS PAREN
- Milone E, 1982, Minerva Chir, V37, P641
- NUNDY S, 1977, GASTROENTEROLOGY, V72, P263
- OBERTOP H, 1977, GASTROENTEROLOGY, V72, P267
- Rasslan S, 1984, AN PAUL MED CIR, V111, P13
- Rasslan S, 1990, ACTA CIR BRAS, V5, P99
- Saad Junior R, 1985, Rev Paul Med, V103, P171
- THOMPSON JS, 1994, GASTROENTEROL CLIN N, V23, P403
- Waisberg DR, 2011, ACTA CIR BRAS, V26, P496, DOI 10.1590/S0102-86502011000600015
- WARNER BW, 1993, PEDIATR CLIN N AM, V40, P1335
- 1989, REV ESP ENFERM APAR, V75, P7
- 2005, ANN SURG, V242, P403, DOI 10.1097/01.SLA.0000179647.24046.03