Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/31870
Title: | Systemic dissemination of glioblastoma: literature review |
Authors: | CARVALHO, Juliana Arcangelo Di Vita; BARBOSA, Caroline Chaul de Lima; FEHER, Olavo; MALDAUN, Marcos Vinicius Calfat; CAMARGO, Veridiana Pires de; MORAES, Fabio Y.; MARTA, Egustavo Nader |
Citation: | REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.65, n.3, p.460-468, 2019 |
Abstract: | INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant tumor from the central nervous system in adults. However, the presence of systemic metastasis is an extremely rare event. The objective of this study was to review the literature, evaluating the possible biological mechanisms related to the occurrence of systemic metastasis in patients diagnosed with GBM. RESULTS: The mechanisms that may be related to GBM systemic dissemination are the blood-brain barrier breach, often seen in GBM cases, by the tumor itself or by surgical procedures, gaining access to blood and lymphatic vessels, associated with the acquisition of mesenchymal features of invasiveness, resistance to the immune mechanisms of defense and hostile environment through quiescence. CONCLUSIONS: Tumor cells must overcome many obstacles until the development of systemic metastasis. The physiologic mechanisms are not completely clear. Although not fully understood, the pathophysiological understanding of the mechanisms that may be associated with the systemic spread is salutary for a global understanding of the disease. In addition, this knowledge may be used as a basis for a therapy to be performed in patients diagnosed with GBM distant metastasis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_CARVALHO_Systemic_dissemination_of_glioblastoma_literature_review_2019.PDF | publishedVersion (English) | 264.24 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.