Asymptomatic Plasmodium infection in a residual malaria transmission area in the Atlantic Forest region: Implications for elimination

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MIGUEL, Renata Bortolasse
ALBUQUERQUE, Hermano Gomes
SANCHEZ, Maria Carmen Arroyo FMUSP-HC
COURA, Jose Rodrigues
SANTOS, Simone da Silva
SILVA, Sidnei da
MOREIRA, Carlos Jose de Carvalho
SUAREZ-MUTIS, Martha Cecilia
dc.date.issued 2019
dc.identifier.citation REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, v.52, article ID UNSP e20180537, 9p, 2019
dc.identifier.issn 0037-8682
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/32034
dc.description.abstract Introduction: Elimination of malaria in areas of interrupted transmission warrants careful case assessment to avoid the reintroduction of this disease. Occasional malaria cases are reported among visitors of the Atlantic Forest area of Brazil, while data on residents of this area are scarce. Methods: A sectional study was carried out to examine 324 individuals living in a municipality where autochthonous cases were detected. Results: Asymptomatic Plasmodium infections were detected in 2.8% of the individuals by polymerase chain reaction (PCR), with one case of P. falciparum (0.3%), two cases of P. vivax (0.6%), and six cases of P. malariae (1.9%). The thick blood smears were negative in all individuals. Serological tests performed in 314 subjects were reactive in 11.1%, with 3.5% for P. falciparum and 7.7% for R. vivax. A subsample of 42 reactive individuals for any Plasmodium species showed R. malariae in 30.9% of specimens. Individuals who entered the Atlantic Forest region were 2.7 times more likely to exhibit reactive serology for P. vivax compared with individuals who did not enter this region (p<0.05). Children <15 years had a higher chance of reactive serology for P. falciparum and P. vivax than individuals >= 15 years of age (p<0.05). Individuals living in the Paraiso district had a higher chance of reactive serology for P. vivax compared to other districts (p<0.05). No associations were found between sex, past exposure to malaria, or serological response to antibodies of any Plasmodium species. Conclusions: The implications of these results for the elimination of malaria were discussed.
dc.description.sponsorship · Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [214879/E_06/2015]
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
dc.language.iso eng
dc.publisher SOC BRASILEIRA MEDICINA TROPICAL
dc.relation.ispartof Revista da Sociedade Brasileira de Medicina Tropical
dc.rights openAccess
dc.subject Malaria; Plasmodium infection; Extra-Amazonian region; Elimination; Rio de Janeiro State
dc.subject.other rio-de-janeiro; sao-paulo; autochthonous malaria; epidemiologic aspects; howler monkeys; state; brazil; identification
dc.title Asymptomatic Plasmodium infection in a residual malaria transmission area in the Atlantic Forest region: Implications for elimination
dc.type article
dc.rights.holder Copyright SOC BRASILEIRA MEDICINA TROPICAL
dc.description.group LIM/38
dc.identifier.doi 10.1590/0037-8682-0537-2018
dc.identifier.pmid 30942262
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SANCHEZ, Maria Carmen Arroyo:IMT:SCSORO-83
hcfmusp.author.external · MIGUEL, Renata Bortolasse:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil; Fiocruz MS, Inst Oswaldo Cruz, Programa Posgrad Med, Rio De Janeiro, RJ, Brazil
· ALBUQUERQUE, Hermano Gomes:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil; Fiocruz MS, Inst Oswaldo Cruz, Programa Posgrad Med, Rio De Janeiro, RJ, Brazil
· COURA, Jose Rodrigues:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil; Fiocruz MS, Inst Oswaldo Cruz, Programa Posgrad Med, Rio De Janeiro, RJ, Brazil
· SANTOS, Simone da Silva:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil
· SILVA, Sidnei da:Inst Nacl Infectol, Lab Parasitol, Rio De Janeiro, RJ, Brazil
· MOREIRA, Carlos Jose de Carvalho:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil
· SUAREZ-MUTIS, Martha Cecilia:Fiocruz MS, Inst Oswaldo Cruz, Lab Doencas Parasitarias, Rio De Janeiro, RJ, Brazil; Fiocruz MS, Inst Oswaldo Cruz, Programa Posgrad Med, Rio De Janeiro, RJ, Brazil
hcfmusp.origem.id WOS:000463233500001
hcfmusp.origem.id 2-s2.0-85064194704
hcfmusp.origem.id SCIELO:S0037-86822019000100316
hcfmusp.publisher.city BRASILIA
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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