Non-alcoholic fatty liver disease presence and severity are associated with aortic stiffness beyond abdominal obesity: The ELSA-Brasil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author HARADA, Paulo H. FMUSP-HC
BENSENOR, Isabela J. M. FMUSP-HC
DRAGER, Luciano F. FMUSP-HC
GOULART, Alessandra C. FMUSP-HC
MILL, Jose G.
LOTUFO, Paulo A. FMUSP-HC
dc.date.issued 2019
dc.identifier.citation ATHEROSCLEROSIS, v.284, p.59-65, 2019
dc.identifier.issn 0021-9150
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/32408
dc.description.abstract Background and aims: It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with aortic stiffness in a racial/ethnically diverse and admixed society. We addressed whether NAFLD presence and severity were associated with carotid-femoral pulse wave velocity (cf-PWV) in individuals free of cardiovascular disease. Methods: In 7196 individuals free of cardiovascular disease at the baseline Brazilian longitudinal study of adult health, we classified NAFLD presence and severity (mild, moderate and severe) by ultrasound hepatic attenuation. We measured cf-PWV using a non-invasive validated device (Complior SP, Artech Medicale France). We compared cf-PWV of NAFLD individuals to those without by analysis of covariance adjusted for demographics, life style, waist circumference, and arterial pressure. We also analyzed the cf-PWV trend from no-NAFLD to severe NAFLD. Results: In unadjusted analysis, from no-NAFLD to severe NAFLD, there were slightly older individuals, lower frequency of smokers, more prevalent diabetes and hypertension. In adjusted analysis, there was slightly higher cf-PWV (m/s) (95% CI) in NAFLD vs. no-NAFLD, respectively 9.32 (9.22, 9.41) and 9.24 (9.15, 9.33) (p= 0.037). Across NAFLD severity spectrum, adjusted cf-PWV increased from 9.24 (9.15, 9.33) in no-NAFLD to 9.69 (9.46, 9.93) in severe NAFLD (p for trend association= 0.001). In sensitivity analysis, diabetes adjustment nullified the association of binary NAFLD with cf-PWV, but not that of increasingly severe NAFLD. Conclusions: In racial/ethnically diverse individuals free of cardiovascular disease, NAFLD is associated with aortic stiffness beyond abdominal obesity. The specific NAFLD impact on CVD worldwide is potentially relevant.
dc.description.sponsorship · Brazil Health Ministry
· Brazil Science and Technology Ministry (Financiadora de Estudos e Projetos)
· Brazil Science and Technology Ministry (CNPq National Research Council) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
dc.language.iso eng
dc.publisher ELSEVIER IRELAND LTD
dc.relation.ispartof Atherosclerosis
dc.rights restrictedAccess
dc.subject Non-alcoholic fatty liver disease; Hepatic steatosis; Aortic stiffness; Carotid femoral pulse wave velocity; Subclinical cardiovascular disease; Obesity; Race/ethnical diversity
dc.subject.other increased arterial stiffness; pulse-wave velocity; cardiovascular events; follow-up; metabolic syndrome; risk; interleukin-6; mortality; atherosclerosis; organization
dc.title Non-alcoholic fatty liver disease presence and severity are associated with aortic stiffness beyond abdominal obesity: The ELSA-Brasil
dc.type article
dc.rights.holder Copyright ELSEVIER IRELAND LTD
dc.description.group LIM/09
dc.description.group LIM/20
dc.description.group LIM/51
dc.identifier.doi 10.1016/j.atherosclerosis.2019.02.005
dc.identifier.pmid 30875494
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author HARADA, Paulo H.:HU:
hcfmusp.author BENSENOR, Isabela J. M.:FM:MCM
hcfmusp.author DRAGER, Luciano F.:FM:MCM
hcfmusp.author GOULART, Alessandra C.:HU:SCPACEX-62
hcfmusp.author LOTUFO, Paulo A.:FM:MCM
hcfmusp.author.external · MILL, Jose G.:Univ Fed Espirito Santo, Dept Physiol Sci, 1468 Marechal Campos Ave, BR-29042755 Vitoria, ES, Brazil
hcfmusp.origem.id WOS:000466155400009
hcfmusp.origem.id 2-s2.0-85062821557
hcfmusp.publisher.city CLARE
hcfmusp.publisher.country IRELAND
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dc.description.index MEDLINE
dc.identifier.eissn 1879-1484
hcfmusp.citation.scopus 1
hcfmusp.citation.wos 1
hcfmusp.affiliation.country Brasil


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