Bullous pemphigoid

Imagem de Miniatura
Arquivos
art_MIYAMOTO_Bullous_pemphigoid_2019.PDF (1.25 MB)
Citações na Scopus
126
Tipo de produção
article
Data de publicação
2019
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASILEIRA DERMATOLOGIA
Autores
Autor de Grupo de pesquisa
Citação
ANAIS BRASILEIROS DE DERMATOLOGIA, v.94, n.2, p.133-146, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Bullous pemphigoid is the most frequent autoimmune bullous disease and mainly affects elderly individuals. Increase in incidence rates in the past decades has been attributed to population aging, drug-induced cases and improvement in the diagnosis of the nonbullous presentations of the disease. A dysregulated T cell immune response and synthesis of IgG and IgE autoantibodies against hemidesmosomal proteins (BP180 and BP230) lead to neutrophil chemotaxis and degradation of the basement membrane zone. Bullous pemphigoid classically manifests with tense blisters over urticarial plaques on the trunk and extremities accompanied by intense pruritus. Mucosal involvement is rarely reported. Diagnosis relies on (1) the histopathological evaluation demonstrating eosinophilic spongiosis or a subepidermal detachment with eosinophils; (2) the detection of IgG and/or C3 deposition at the basement membrane zone using direct or indirect immunofluorescence assays; and (3) quantification of circulating autoantibodies against BP180 and/or BP230 using ELISA. Bullous pemphigoid is often associated with multiple comorbidities in elderly individuals, especially neurological disorders and increased thrombotic risk, reaching a 1-year mortality rate of 23%. Treatment has to be tailored according to the patient's clinical conditions and disease severity. High potency topical steroids and systemic steroids are the current mainstay of therapy. Recent randomized controlled studies have demonstrated the benefit and safety of adjuvant treatment with doxycycline, dapsone and immunosuppressants aiming a reduction in the cumulative steroid dose and mortality.
Palavras-chave
Antibodies, Autoimmunity, Hemidesmosomes, Pemphigoid, bullous, Skin diseases, vesiculobullous
URI
https://observatorio.fm.usp.br/handle/OPI/32468
Referências
  1. Ahmed AR, 2016, J AM ACAD DERMATOL, V74, P700, DOI 10.1016/j.jaad.2015.11.030
  2. Alpsoy E, 2015, ARCH DERMATOL RES, V307, P291, DOI 10.1007/s00403-014-1531-1
  3. Amagai M, 2017, J DERMATOL SCI, V85, P77, DOI 10.1016/j.jdermsci.2016.11.003
  4. Amber KT, 2017, JAMA DERMATOL, V153, P1137, DOI 10.1001/jamadermatol.2017.2808
  5. Atzmony L, 2017, J AM ACAD DERMATOL, V77, P691, DOI 10.1016/j.jaad.2017.05.006
  6. Baican A, 2010, INT J DERMATOL, V49, P768, DOI 10.1111/j.1365-4632.2009.04345.x
  7. Barrick BJ, 2016, J INVEST DERMATOL, V136, P2090, DOI 10.1016/j.jid.2016.06.015
  8. Bastuji-Garin S, 2011, J INVEST DERMATOL, V131, P637, DOI 10.1038/jid.2010.301
  9. Bene J, 2016, BRIT J DERMATOL, V175, P296, DOI 10.1111/bjd.14601
  10. Benzaquen M, 2018, J AM ACAD DERMATOL, V78, P1090, DOI 10.1016/j.jaad.2017.12.038
  11. BROWN LF, 1995, J INVEST DERMATOL, V104, P744, DOI 10.1111/1523-1747.ep12606974
  12. Bystryn JC, 2005, J INVEST DERMATOL, V124, pXX, DOI 10.1111/j.0022-202X.2005.23677.x
  13. Cai SCS, 2015, JAMA DERMATOL, V151, P665, DOI 10.1001/jamadermatol.2014.5263
  14. Chimanovitch I, 2000, ARCH DERMATOL, V136, P527, DOI 10.1001/archderm.136.4.527
  15. Cozzani E, 2015, AUTOIMMUN REV, V14, P438, DOI 10.1016/j.autrev.2015.01.006
  16. Cugno M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129456
  17. Cunha PR, 1998, INT J DERMATOL, V37, P935, DOI 10.1046/j.1365-4362.1998.00615.x
  18. de Vega IF, 2014, ACTAS DERMO-SIFILOGR, V105, P328, DOI 10.1016/j.ad.2012.10.022
  19. Eming R, 2015, J DTSCH DERMATOL GES, V13, P833, DOI 10.1111/ddg.12606
  20. Feliciani C, 2015, BRIT J DERMATOL, V172, P867, DOI 10.1111/bjd.13717
  21. Fisler RE, 2003, AM J DERMATOPATH, V25, P183, DOI 10.1097/00000372-200306000-00001
  22. Fontaine J, 2003, J DERMATOL, V30, P83, DOI 10.1111/j.1346-8138.2003.tb00353.x
  23. Grantham HJ, 2017, LANCET, V389, P1586, DOI 10.1016/S0140-6736(17)30549-4
  24. Holgate S, 2009, ALLERGY, V64, P1728, DOI 10.1111/j.1398-9995.2009.02201.x
  25. Holtsche MM, 2018, BRIT J DERMATOL, V179, P918, DOI 10.1111/bjd.16553
  26. Iwashita Kenichi, 2007, Tokai J Exp Clin Med, V32, P42
  27. Johnson P, 2003, SEMIN ONCOL, V30, P3, DOI 10.1053/sonc.2003.50025
  28. Joly P, 2005, J INVEST DERMATOL, V124, P664, DOI 10.1111/j.0022-202X.2005.23626.x
  29. Joly P, 2002, NEW ENGL J MED, V346, P321, DOI 10.1056/NEJMoa011592
  30. Joly P, 2009, J INVEST DERMATOL, V129, P1681, DOI 10.1038/jid.2008.412
  31. Kershenovich R, 2014, AUTOIMMUN REV, V13, P477, DOI 10.1016/j.autrev.2014.01.011
  32. Kibsgaard L, 2017, BRIT J DERMATOL, V176, P1486, DOI 10.1111/bjd.15405
  33. Kirtschig G, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002292.pub3
  34. Kobayashi TT, 2002, CUTIS, V70, P283
  35. Kokkonen N, 2017, J INVEST DERMATOL, V137, P71, DOI 10.1016/j.jid.2016.09.010
  36. Kridin K, 2018, J AM ACAD DERMATOL
  37. Kridin K, 2019, ACTA DERM-VENEREOL, V99, P72, DOI 10.2340/00015555-2930
  38. Kridin K, 2018, J DERMATOL, V45, P1094, DOI 10.1111/1346-8138.14503
  39. Lai YC, 2016, J EUR ACAD DERMATOL, V30, P2007, DOI 10.1111/jdv.13660
  40. Lamberts A, 2018, J AM ACAD DERMATOL, V78, P989, DOI 10.1016/j.jaad.2017.10.035
  41. Langan SM, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a180
  42. Li L, 2009, BRIT J DERMATOL, V160, P1343, DOI 10.1111/j.1365-2133.2009.09122.x
  43. Li N, 2005, J CLIN INVEST, V115, P3440, DOI 10.1172/JCI24394
  44. Li N, 2018, J INVEST DERMATOL, V138, P1249, DOI 10.1016/j.jid.2018.02.020
  45. Lin L, 2018, J INVEST DERMATOL, V138, P1032, DOI 10.1016/j.jid.2017.11.031
  46. Liu YD, 2017, ARCH DERMATOL RES, V309, P335, DOI 10.1007/s00403-017-1736-1
  47. Lloyd-Lavery A, 2013, JAMA DERMATOL, V149, P58, DOI 10.1001/2013.jamadermatol.376
  48. Lopez AT, 2018, ONCOLOGIST, V23, P1119, DOI 10.1634/theoncologist.2018-0128
  49. Lopez AT, 2018, INT J DERMATOL, V57, P664, DOI 10.1111/ijd.13984
  50. Messingham KAN, 2009, J IMMUNOL METHODS, V346, P18, DOI 10.1016/j.jim.2009.04.013
  51. Messingham KN, 2011, J IMMUNOL, V187, P553, DOI 10.4049/jimmunol.1001753
  52. Meurer M, 2012, CLIN DERMATOL, V30, P78, DOI 10.1016/j.clindermatol.2011.03.013
  53. Miyamoto D, 2016, INT J DERMATOL, V55, pE112, DOI 10.1111/ijd.13034
  54. Monk E, 2011, PHARMACOL RES, V63, P130, DOI 10.1016/j.phrs.2010.10.007
  55. Moosbauer C, 2007, BLOOD, V109, P995, DOI 10.1182/blood-2006-02-004945
  56. MOREL P, 1984, ANN DERMATOL VENER, V111, P925
  57. MURAMATSU T, 1994, ARCH DERMATOL RES, V286, P142, DOI 10.1007/BF00374209
  58. Murrell DF, 2012, J AM ACAD DERMATOL, V66, P479, DOI 10.1016/j.jaad.2011.06.032
  59. Naidoo J, 2016, CANCER IMMUNOL RES, V4, P383, DOI 10.1158/2326-6066.CIR-15-0123
  60. Nanda A, 2004, INT J DERMATOL, V43, P876, DOI 10.1111/j.1365-4632.2004.02292.x
  61. NEMETH AJ, 1991, ARCH DERMATOL, V127, P378, DOI 10.1001/archderm.127.3.378
  62. Nomura H, 2017, EUR J DERMATOL, V27, P95, DOI 10.1684/ejd.2016.2909
  63. OGAWA H, 1995, J DERMATOL SCI, V9, P136, DOI 10.1016/0923-1811(94)00371-K
  64. Ong E, 2014, ARCH DERMATOL RES, V306, P75, DOI 10.1007/s00403-013-1399-5
  65. PERSON JR, 1976, BRIT J DERMATOL, V95, P535, DOI 10.1111/j.1365-2133.1976.tb00865.x
  66. Pfutze M, 2007, EUR J DERMATOL, V17, P4
  67. Primka EJ, 1998, J AM ACAD DERMATOL, V39, P121, DOI 10.1016/S0190-9622(98)70414-1
  68. Ren Z, 2017, BRIT J DERMATOL, V176, P87, DOI 10.1111/bjd.14821
  69. Ronaghy A, 2014, J DERMATOL SCI, V74, P93, DOI 10.1016/j.jdermsci.2013.11.014
  70. Roujeau JC, 1998, ARCH DERMATOL, V134, P465, DOI 10.1001/archderm.134.4.465
  71. Saniklidou AH, 2018, ARCH DERMATOL RES, V310, P11, DOI 10.1007/s00403-017-1789-1
  72. Sardy M, 2013, J AM ACAD DERMATOL, V69, P748, DOI 10.1016/j.jaad.2013.07.009
  73. Schmidt E, 2001, CLIN EXP IMMUNOL, V124, P157, DOI 10.1046/j.1365-2249.2001.01503.x
  74. Schmidt E, 2013, LANCET, V381, P320, DOI 10.1016/S0140-6736(12)61140-4
  75. Schulze F, 2015, J INVEST DERMATOL, V135, P1445, DOI 10.1038/jid.2014.547
  76. Sekiya A, 2014, BRIT J DERMATOL, V171, P1230, DOI 10.1111/bjd.13097
  77. Seppanen AO, 2012, BRIT J DERMATOL, V166, P683, DOI 10.1111/j.1365-2133.2011.10641.x
  78. Sibaud V, 2018, AM J CLIN DERMATOL, V19, P345, DOI 10.1007/s40257-017-0336-3
  79. Sim B, 2017, J EUR ACAD DERMATOL, V31, P1709, DOI 10.1111/jdv.14312
  80. Stavropoulos PG, 2014, J EUR ACAD DERMATOL, V28, P1133, DOI 10.1111/jdv.12366
  81. Sticherling M, 2017, BRIT J DERMATOL, V177, P1299, DOI 10.1111/bjd.15649
  82. Taquin H, 2016, PEDIATR DERMATOL, V33, pE77, DOI 10.1111/pde.12779
  83. Thomsen K, 2018, CASE REP DERMATOL, V10, P154, DOI 10.1159/000489661
  84. Ujiie H, 2018, J INVEST DERMATOL, V138, P1201, DOI 10.1016/j.jid.2017.11.023
  85. Ujiie H, 2011, DERMATOL CLIN, V29, P439, DOI 10.1016/j.det.2011.03.008
  86. van Beek N, 2017, JAMA DERMATOL, V153, P30, DOI 10.1001/jamadermatol.2016.3357
  87. Vanderlugt CJ, 1996, CURR OPIN IMMUNOL, V8, P831, DOI 10.1016/S0952-7915(96)80012-4
  88. Venning VA, 2012, BRIT J DERMATOL, V167, P1200, DOI 10.1111/bjd.12072
  89. Voltan E, 2005, J DERMATOL, V32, P387, DOI 10.1111/j.1346-8138.2005.tb00912.x
  90. Waisbourd-Zinman O, 2008, J AM ACAD DERMATOL, V58, P41, DOI 10.1016/j.jaad.2007.08.010
  91. Washio K, 2013, CASE REP DERMATOL, V5, P84, DOI 10.1159/000350285
  92. Wijayanti A, 2017, ACTA DERM-VENEREOL, V97, P24, DOI 10.2340/00015555-2473
  93. Wilczek A, 2006, INT J DERMATOL, V45, P1353, DOI 10.1111/j.1365-4632.2006.02861.x
  94. Williams HC, 2017, LANCET, V389, P1630, DOI 10.1016/S0140-6736(17)30560-3
  95. Wong SN, 2002, BRIT J DERMATOL, V147, P476, DOI 10.1046/j.1365-2133.2002.04919.x
  96. Yang YW, 2011, STROKE, V42, P319, DOI 10.1161/STROKEAHA.110.596361
  97. Yayli S, 2011, BRIT J DERMATOL, V165, P1133, DOI 10.1111/j.1365-2133.2011.10481.x
  98. Zuo YG, 2016, J AUTOIMMUN, V73, P111, DOI 10.1016/j.jaut.2016.06.019

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - LIM/56