First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP KOSTIC, Dusan FMUSP-HC
BEOZZO, Glenda Priscila Neves dos Santos FMUSP-HC
COUTO, Saulo Brasil do FMUSP-HC
KATO, Andre Henrique Teruaki FMUSP-HC
KREBS, Vera Lucia Jornada FMUSP-HC
FRANCISCO, Rossana Pulcineli Vieira FMUSP-HC
CARVALHO, Werther Brunow de FMUSP-HC
KOCH, Vera Hermina Kalika FMUSP-HC 2019
dc.identifier.citation PEDIATRIC NEPHROLOGY, v.34, n.6, p.1117-1128, 2019
dc.identifier.issn 0931-041X
dc.description.abstract Background Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage. Methods This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-beta 1), retinol-binding protein (RBP), cystatin C (mu CyC), and microalbuminuria (ALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Results All urine biomarkers showed significantly higher values at the first month of life (p <= 0.009), while NGAL (p = 0.005), TGF-beta 1 (p<0.001), and mu ALB (p<0.001) were high since birth compared to controls. Best single biomarker performances were RBP in bilateral hydronephrosis and LUTO subgroups and KIM-1 in unilateral hydronephrosis subgroup. Best biomarker combination results for all subgroups were obtained by matching RBP with TGF-beta 1 or KIM-1 and NGAL with CyC ([AUC] <= 0.934; sensitivity <= 92.4%; specificity <= 92.8%). Conclusions RBP, NGAL, KIM-1, TGF-beta 1, and CyC, alone and especially in combination, are relatively efficient in identifying surgically amenable congenital UTO and could be of practical use in indicating on-time surgery.
dc.description.sponsorship · Sao Paulo Research Foundation-FAPESP Grant [2012/50337-9]
dc.language.iso eng
dc.publisher SPRINGER
dc.relation.ispartof Pediatric Nephrology
dc.rights restrictedAccess
dc.subject Congenital urinary tract obstruction; Hydronephrosis; Renal biomarkers; Infants
dc.subject.other ureteropelvic junction obstruction; cystatin-c; children; newborn; kidney; hydronephrosis; classification; dilatation; creatinine; management
dc.title First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction
dc.type article
dc.rights.holder Copyright SPRINGER LIM/36 LIM/57
dc.identifier.doi 10.1007/s00467-019-4195-4
dc.identifier.pmid 30694385
dc.type.category original article
dc.type.version publishedVersion KOSTIC, Dusan:HC:ICR BEOZZO, Glenda Priscila Neves dos Santos:HC:ICR COUTO, Saulo Brasil do:FM: KATO, Andre Henrique Teruaki:HC:ICHC LIMA, Laila:HC:INCOR PALMEIRA, Patricia:FM: KREBS, Vera Lucia Jornada:HC:ICR BUNDUKI, Victor:FM:MOG FRANCISCO, Rossana Pulcineli Vieira:FM:MOG ZUGAIB, Marcelo:FM:MOG CARVALHO, Werther Brunow de:FM:MPE KOCH, Vera Hermina Kalika:HC:ICR WOS:000468519900017 2-s2.0-85061047209 NEW YORK USA
hcfmusp.relation.reference · Abitbol CL, 2016, PEDIATR NEPHROL, V31, P2213, DOI 10.1007/s00467-016-3320-x
· Anumba DO, 2005, PRENATAL DIAG, V25, P7, DOI 10.1002/pd.1074
· BANGSTAD HJ, 1995, PEDIATR NEPHROL, V9, P299, DOI 10.1007/BF02254190
· Chevalier RL, 2008, PEDIATR RADIOL, V38, pS35, DOI 10.1007/s00247-007-0585-z
· Chevalier RL, 2006, CURR OPIN PEDIATR, V18, P153, DOI 10.1097/01.mop.0000193287.56528.a4
· Chevalier Robert L., 2003, Pediatric Nephrology, V18, P576
· Chevalier RL, 2010, PEDIATR NEPHROL, V25, P687, DOI 10.1007/s00467-009-1316-5
· Decramer S, 2006, NAT MED, V12, P398, DOI 10.1038/nm1384
· Decramer S, 2008, CONTRIB NEPHROL, V160, P127, DOI 10.1159/000125956
· Dell KM, 2000, UROLOGY, V56, P311, DOI 10.1016/S0090-4295(00)00591-4
· El-Sherbiny MT, 2002, J UROLOGY, V168, P1798, DOI 10.1097/01.ju.0000027231.84450.8f
· Finney H, 2000, ARCH DIS CHILD, V82, P71, DOI 10.1136/adc.82.1.71
· Fiorini F, 2007, J Ultrasound, V10, P161, DOI 10.1016/j.jus.2007.09.001
· Freedman AL, 1997, FETAL DIAGN THER, V12, P1, DOI 10.1159/000264415
· Gerber C, 2016, J PEDIATR UROL, V12, DOI 10.1016/j.jpurol.2015.10.008
· GRIGNON A, 1986, RADIOLOGY, V160, P645, DOI 10.1148/radiology.160.3.3526402
· Hossain MA, 2009, AM J NEPHROL, V29, DOI 10.1159/000168486
· Huang WY, 2006, KIDNEY INT, V69, P137, DOI 10.1038/
· Ismaili K, 2003, AM J OBSTET GYNECOL, V188, P242, DOI 10.1067/mob.2003.81
· Jetton JG, 2012, CURR OPIN PEDIATR, V24, P191, DOI 10.1097/MOP.0b013e32834f62d5
· Karakus S, 2016, UROLOGY, V87, P185, DOI 10.1016/j.urology.2015.09.007
· Klein J, 2011, INT J EXP PATHOL, V92, P168, DOI 10.1111/j.1365-2613.2010.00727.x
· Lee RS, 2006, PEDIATRICS, V118, P586, DOI 10.1542/peds.2006-0120
· Lee RS, 2009, CURR OPIN UROL, V19, P397, DOI 10.1097/MOU.0b013e32832c90ec
· Madsen MG, 2013, DAN MED J, V60
· Madsen MG, 2011, J PEDIATR UROL, V7, P105, DOI 10.1016/j.jpurol.2010.12.004
· Maisels MJ, 2004, PEDIATRICS, V114, P297
· Mandelia A, 2013, PEDIATR NEPHROL, V28, P1991, DOI 10.1007/s00467-013-2506-8
· Miklovicova D, 2008, PEDIATR NEPHROL, V23, P937, DOI 10.1007/s00467-007-0741-6
· Misseri R, 2004, J SURG RES, V119, P149, DOI 10.1016/j.jss.2004.02.016
· Morris RK, 2008, BEST PRACT RES CL OB, V22, P97, DOI 10.1016/j.bpobgyn.2007.08.007
· Morris RK, 2013, LANCET, V382, P1496, DOI 10.1016/S0140-6736(13)60992-7
· Murer L, 2006, J UROLOGY, V176, P2668, DOI 10.1016/j.juro.2006.08.055
· Nguyen HT, 2014, J PEDIATR UROL, V10, P982, DOI 10.1016/j.jpurol.2014.10.002
· Nguyen HT, 2010, J PEDIATR UROL, V6, P212, DOI 10.1016/j.jpurol.2010.02.205
· Noyan A, 2015, J PEDIATR UROL, V11, DOI 10.1016/j.jpurol.2015.02.021
· Olvera-Posada D, 2017, J ENDOUROL, V31, P111, DOI 10.1089/end.2016.0215
· Pasala S, 2017, ARCH DIS CHILDHOOD-E, V102, P37, DOI 10.1136/archdischild-2016-311062
· PETERS CA, 1995, J UROLOGY, V154, P1874, DOI 10.1016/S0022-5347(01)66815-0
· Schwartz GJ, 2009, CLIN J AM SOC NEPHRO, V4, P1832, DOI 10.2215/CJN.01640309
· Taha MA, 2007, BJU INT, V99, P899, DOI 10.1111/j.1464-410X.2006.06641.x
· TOMLINSON PA, 1994, PEDIATR NEPHROL, V8, P21, DOI 10.1007/BF00868252
· Trnka P, 2012, CLIN J AM SOC NEPHRO, V7, P1567, DOI 10.2215/CJN.09640911
· Truong LD, 2011, CONTRIB NEPHROL, V169, P311, DOI 10.1159/000314578
· Villar J, 2014, LANCET, V384, P857, DOI 10.1016/S0140-6736(14)60932-6
· Wasilewska A, 2011, PEDIATR NEPHROL, V26, P579, DOI 10.1007/s00467-011-1773-5
· Wuhl E, 2013, CLIN J AM SOC NEPHRO, V8, P67, DOI 10.2215/CJN.03310412
dc.description.index MEDLINE
dc.identifier.eissn 1432-198X
hcfmusp.citation.wos 0

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account