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https://observatorio.fm.usp.br/handle/OPI/32526| Title: | Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders |
| Authors: | CARVALHO, Carolina Muniz; PAN, Pedro M.; OTA, Vanessa K.; SPINDOLA, Leticia M.; XAVIER, Gabriela; SANTORO, Marcos L.; MAZZOTTI, Diego R.; PELLEGRINO, Renata; HAKONARSON, Hakon; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; GADELHA, Ary; BRESSAN, Rodrigo A.; BELANGERO, Sintia I. |
| Citation: | PSYCHIATRY RESEARCH, v.273, p.575-577, 2019 |
| Abstract: | We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G x CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G x CM with either MD or psychopathology. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - LIM/23 Artigos e Materiais de Revistas Científicas - ODS/16 |
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| art_CARVALHO_Effects_of_the_interaction_between_genetic_factors_and_2019.PDF Restricted Access | publishedVersion (English) | 177 kB | Adobe PDF | View/Open Request a copy |
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