Impact of Brush Cytology Analysis for the Diagnosis of Esophageal Squamous Cell Carcinoma: The Quality of Liquid-Based Preparation of Cytological Slides

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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2019
Editora
KARGER
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Título do Volume
Autores
MARIANO, Vania S.
PASTREZ, Paula R. A.
COSTA, Allini Mafra
GUIMARAES, Denise P.
CUNHA, Thiago R.
NETO, Said A. Z.
SCAPULATEMPO-NETO, Christovam
SYRJANEN, Kari J.
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Citação
ACTA CYTOLOGICA, v.63, n.3, p.240-246, 2019
Projetos de Pesquisa
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Resumo
Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduodenoscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis. (C) 2019 S. Karger AG, Basel
Palavras-chave
Esophageal squamous cell cancer, Brush cytology, Liquid-based cytology, SurePath
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