Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards

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art_FARFEL_Alzheimers_disease_frequency_peaks_in_the_tenth_decade_2019.PDF (1011.4 KB)
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2019
Editora
BMC
DOI
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Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
YU, Lei
BOYLE, Patricia A.
LEURGANS, Sue
SHAH, Raj C.
SCHNEIDER, Julie A.
BENNETT, David A.
Autor de Grupo de pesquisa
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Coordenadores
Organizadores
Citação
ACTA NEUROPATHOLOGICA COMMUNICATIONS, v.7, article ID 104, 9p, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Age is the most robust risk factor for Alzheimer's dementia, however there is little data on the relation of age to Alzheimer's disease (AD) and other common neuropathologies that contribute to Alzheimer's dementia. We use data from two community-based, clinical-pathologic cohorts to examine the association of age with AD and other common pathologies. Participants were 1420 autopsied individuals from the Religious Orders Study or Rush Memory and Aging Project who underwent annual clinical evaluations for diagnosis of Alzheimer's dementia, mild cognitive impairment (MCI), and level of cognition. The neuropathologic traits of interest were pathologic AD according to modified NIA-Reagan criteria, three quantitative measures of AD pathology (global AD pathology score, beta-amyloid load and PHFtau tangle density), macro- and micro-scopic infarcts, neocortical Lewy bodies, TDP-43 and hippocampal sclerosis. Semiparametric generalized additive models examined the nonlinear relationship between age and the clinical and pathological outcomes. The probability of Alzheimer's dementia at death increased with age such that for every additional year of age, the log odds of Alzheimer's dementia was 0.067 higher, corresponding to an odds ratio of 1.070 (p<0.001). Results were similar for cognitive impairment and level of cognition. By contrast, a nonlinear relationship of age with multiple indices of AD pathology was observed (all ps<0.05), such that pathologic AD reached a peak around 95years of age and leveled off afterwards; the quantitative measures of AD pathology were significantly lower at ages above 95. The association of age with other neuropathologies was quite distinct from that of AD in that most increased with advancing age. AD pathology appears to peak around 95years of age while other common pathologies continue to increase with age.
Palavras-chave
Alzheimer's disease, Age, Neuropathology, Tau protein, Amyloid
URI
https://observatorio.fm.usp.br/handle/OPI/32978
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/22