A possible association between fructose consumption and pulmonary emphysema
Carregando...
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
TOLEDO-ARRUDA, Alessandra Choqueta de
VIEIRA, Rodolfo de Paula
Citação
SCIENTIFIC REPORTS, v.9, article ID 9344, 9p, 2019
Resumo
Chronic Obstructive Pulmonary Disease (COPD) is a syndrome that comprises several distinct and overlapping phenotypes. In addition to persistent airflow limitation and respiratory symptoms, COPD is also characterized by chronic systemic inflammation. Epidemiological studies have shown that dietary fibers, fruits and vegetables intake protects against the COPD development, while fructose-loading is associated with increased risk of asthma and chronic bronchitis. Since dietary factors might affect susceptibility to COPD by modulating oxidative stress and inflammatory responses, we evaluated how fructose feeding might affect the smoking-induced emphysema in mice. We found that chronic fructose intake induced destruction and remodeling of lung parenchyma and impairment of respiratory mechanics, which are associated with distinctive cytokine profiles in bronchoalveolar lavage fluid, blood plasma and skeletal muscle. The combined effects of chronic fructose intake and cigarette smoking on destruction of lung parenchyma are more pronounced than the effects of either alone. Excessive intake of fructose might directly cause pulmonary emphysema in mice rather than just altering its natural history by facilitating the installation of a low-grade systemic inflammatory milieu.
Palavras-chave
Referências
- [Anonymous], 2018, GLOBAL INITIATIVE CH
- [Anonymous], 2018, CHRONIC OBSTRUCTIVE
- Barnes PJ, 2009, EUR RESPIR J, V33, P1165, DOI 10.1183/09031936.00128008
- Barnes PJ, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.76
- Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
- Basaranoglu M, 2013, WORLD J GASTROENTERO, V19, P1166, DOI 10.3748/wjg.v19.i8.1166
- BRETT J, 1993, AM J PATHOL, V143, P1699
- Cao C, 2015, SCI REP-UK, V5, DOI 10.1038/srep16461
- Ceddia RB, 2005, INT J OBESITY, V29, P1175, DOI 10.1038/sj.ijo.0803025
- DeChristopher LR, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.7
- DeChristopher LR, 2015, EUR J CLIN NUTR, V69, P1371, DOI 10.1038/ejcn.2015.101
- DeChristopher LR, 2018, BRIT J NUTR, V119, P1157, DOI 10.1017/S0007114518000417
- DeChristopher LR, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0097-x
- DeChristopher LR, 2016, PUBLIC HEALTH NUTR, V19, P123, DOI 10.1017/S1368980015000865
- Diamantis E, 2017, CURR CARDIOL REV, V13, P209, DOI 10.2174/1573403X13666170426104611
- Divo M, 2012, AM J RESP CRIT CARE, V186, P155, DOI 10.1164/rccm.201201-0034OC
- Forno E, 2015, J ALLERGY CLIN IMMUN, V136, P304, DOI 10.1016/j.jaci.2015.01.010
- Gomes RFM, 2000, J APPL PHYSIOL, V89, P908
- Gugliucci A, 2017, ADV NUTR, V8, P54, DOI 10.3945/an.116.013912
- Hanson C, 2016, ANN AM THORAC SOC, V13, P643, DOI 10.1513/AnnalsATS.201509-609OC
- HANTOS Z, 1992, J APPL PHYSIOL, V72, P168
- Janda S, 2009, CHEST, V136, P734, DOI 10.1378/chest.09-0194
- Jenke A, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13523
- Kaluza J, 2018, EPIDEMIOLOGY, V29, P254, DOI 10.1097/EDE.0000000000000750
- Kaluza J, 2017, THORAX, V72, P500, DOI 10.1136/thoraxjnl-2015-207851
- Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
- LANG MR, 1994, THORAX, V49, P319, DOI 10.1136/thx.49.4.319
- Lopes FDTQS, 2013, HISTOL HISTOPATHOL, V28, P269, DOI 10.14670/HH-28.269
- Mackenzie B, 2016, MED SCI SPORT EXER, V48, P1459, DOI 10.1249/MSS.0000000000000927
- Malik VS, 2015, J AM COLL CARDIOL, V66, P1615, DOI 10.1016/j.jacc.2015.08.025
- Martinez-Martinez E, 2016, J MOL CELL CARDIOL, V92, P96, DOI 10.1016/j.yjmcc.2016.01.012
- MAYES PA, 1993, AM J CLIN NUTR, V58, P754
- Milutinovic PS, 2012, AM J PATHOL, V181, P1215, DOI 10.1016/j.ajpath.2012.06.031
- Park S, 2016, PREV MED, V91, P58, DOI 10.1016/j.ypmed.2016.08.004
- Prado CM, 2006, AM J RESP CELL MOL, V35, P457, DOI 10.1165/rcmb.2005-0391OC
- Ramos DS, 2010, MED SCI SPORT EXER, V42, P113, DOI 10.1249/MSS.0b013e3181ad1c72
- Rastogi Deepa, 2014, Ann Am Thorac Soc, V11, P744, DOI 10.1513/AnnalsATS.201311-403OC
- Singh VP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129850
- Takubo Y, 2002, AM J RESP CRIT CARE, V166, P1596, DOI 10.1164/rccm.2202001
- Toledo AC, 2012, EUR RESPIR J, V39, P254, DOI 10.1183/09031936.00003411
- Van Herck MA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101072
- van Huisstede A, 2013, J OBES, DOI 10.1155/2013/131349
- Walker RW, 2012, J AM COLL NUTR, V31, P369, DOI 10.1080/07315724.2012.10720445
- WEIBEL ER, 1963, LAB INVEST, V12, P131
- Yin HL, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006836
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - ODS/03