Activation of Interleukin-1 Beta in Arterialized Vein Grafts and the Influence of the -511C/T IL-1 beta Gene Polymorphism
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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
BONIN, Thaiz Ferraz
CAMPOS, Luciene Cristina Gastalho
Citação
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, v.6, n.2, article ID 20, 8p, 2019
Resumo
The interleukin-1 family is associated with innate immunity and inflammation. The latter has been linked to the genesis of cardiovascular diseases. We, therefore, investigated whether interleukin-1 beta (IL-1 beta) is activated during arterialization of vein grafts. First, we examined the activation of IL-1 beta using the rat arterialized jugular vein serially sampled for up to 90 days. IL-1 beta expression increased 18 times on day 1 in the arterialized rat jugular vein and remained five times above nonarterialized vein levels for up to 90 days. Similarly, IL-1 beta expression increased early (1-5 days) in human vein graft autopsy samples compared with late phases (1-4 years). Activation was also detected in ex vivo arterialized human saphenous veins. Upon stratification of the results, we uncovered a T allele promoter attenuating effect in IL-1 beta activation in response to hemodynamic stress. Altogether, the results show that IL-1 beta is activated during arterialization of vein grafts in rats and humans, and this response is modulated by -511C/T IL-1 beta gene polymorphism. It is tempting to speculate that the activation of IL-1 beta, and consequently local inflammation, modulates early vascular remodeling and that the gene polymorphism may be useful in predicting outcomes or assisting in interventions.
Palavras-chave
human saphenous vein, interleukin-1 beta, vein graft, gene polymorphisms
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