Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/33070
Title: | Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis |
Authors: | YOSHIKAWA, Fabio Seiti Yamada; LIMA, Josenilson Feitosa de; SATO, Maria Notomi; RAMOS, Yasmin Alefe Leuzzi; AOKI, Valeria; ORFALI, Raquel Leao |
Citation: | TOXINS, v.11, n.6, 2019 |
Abstract: | Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/56 |
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File | Description | Size | Format | |
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art_YOSHIKAWA_Exploring_the_Role_of_Staphylococcus_Aureus_Toxins_in_2019.PDF | publishedVersion (English) | 856.74 kB | Adobe PDF | View/Open |
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