Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study
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Citações na Scopus
33
Tipo de produção
article
Data de publicação
2019
Editora
WILEY
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Citação
JOURNAL OF BONE AND MINERAL RESEARCH, v.34, n.7, p.1264-1274, 2019
Resumo
Body composition changes as a result of ageing may impact the survival of older adults. However, its influence on mortality risk is uncertain. Currently, the best method for body composition analysis in clinical practice is DXA. Nonetheless, the few studies on body composition by DXA and mortality risk in the elderly have some limitations. We investigated the association between body composition by DXA and mortality in a cohort of elderly subjects. Eight hundred thirty-nine community-dwelling subjects (516 women, 323 men) >= 65 years of age were assessed by a questionnaire, clinical data, laboratory exams, and body composition by DXA at baseline. Total fat and its components (eg, visceral adipose tissue [VAT]) were estimated. Appendicular lean mass (ALM) adjusted for fat and ALM divided by height(2) was used to ascertain the presence of low muscle mass (LMM). Mortality was recorded during follow-up. Multivariate logistic regression was used to compute ORs for all-cause and cardiovascular mortality. Over a mean follow-up of 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. In men, after adjustment for relevant variables, the presence of LMM (OR, 11.36, 95% CI, 2.21 to 58.37, P = 0.004) and VAT (OR, 1.99, 95% CI, 1.38 to 2.87, P < 0.001, for each 100-g increase) significantly increased all-cause mortality risk, whereas total fat, measured by the fat mass index, was associated with decreased mortality risk (OR, 0.48, 95% CI, 0.33 to 0.71, P < 0.001). Similar results were observed for cardiovascular mortality. In women, only LMM was a predictor of all-cause (OR, 62.88, 95% CI, 22.59 to 175.0, P < 0.001) and cardiovascular death (OR, 74.54, 95% CI, 9.72 to 571.46, P < 0.001). LMM ascertained by ALM adjusted for fat and fat mass by itself are associated with all-cause and cardiovascular mortality risk in the elderly. Visceral and subcutaneous fat have opposite roles on mortality risk in elderly men. Thus, DXA is a promising tool to estimate risk of mortality in the elderly. (c) 2019 American Society for Bone and Mineral Research.
Palavras-chave
AGEING, DXA, MORTALITY, SARCOPENIA, VISCERAL ADIPOSE TISSUE
Referências
- Altman DG, 2000, STAT MED, V19, P3275, DOI 10.1002/1097-0258(20001215)19:23<3275::AID-SIM626>3.0.CO;2-M
- Batsis JA, 2016, INT J OBESITY, V40, P761, DOI 10.1038/ijo.2015.243
- Baumgartner RN, 1998, AM J EPIDEMIOL, V147, P755
- Bea JW, 2015, AM J EPIDEMIOL, V182, P585, DOI 10.1093/aje/kwv103
- Bunout D, 2011, AUSTRALAS J AGEING, V30, P89, DOI 10.1111/j.1741-6612.2010.00448.x
- Cesari M, 2009, J GERONTOL A-BIOL, V64, P377, DOI 10.1093/gerona/gln031
- Chuang SY, 2014, NUTR METAB CARDIOVAS, V24, P784, DOI 10.1016/j.numecd.2013.11.010
- Cruz-Jentoft AJ, 2019, AGE AGEING, V48, P16, DOI 10.1093/ageing/afy169
- Delmonico MJ, 2007, J AM GERIATR SOC, V55, P769, DOI 10.1111/j.1532-5415.2007.01140.x
- Domiciano DS, 2014, OSTEOPOROSIS INT, V25, P2805, DOI 10.1007/s00198-014-2821-3
- Domiciano DS, 2013, OSTEOPOROSIS INT, V24, P595, DOI 10.1007/s00198-012-2002-1
- Domiciano DS, 2016, J BONE MINER RES, V31, P1146, DOI 10.1002/jbmr.2795
- Enoki H, 2007, CLIN NUTR, V26, P597, DOI 10.1016/j.clnu.2007.06.008
- Figueiredo CP, 2014, OSTEOPOROSIS INT, V25, P589, DOI 10.1007/s00198-013-2455-x
- GENANT HK, 1993, J BONE MINER RES, V8, P1137, DOI 10.1002/jbmr.5650080915
- Graf CE, 2016, CLIN NUTR, V35, P1499, DOI 10.1016/j.clnu.2016.04.003
- Hanai T, 2015, NUTRITION, V31, P193, DOI 10.1016/j.nut.2014.07.005
- Honda H, 2007, AM J CLIN NUTR, V86, P633
- Jensen MK, 2013, CIRCULATION, V127, DOI 10.1161/01.cir.0000437739.71477.ee
- Karakelides H, 2005, CURR TOP DEV BIOL, V68, P123, DOI 10.1016/S0070-2153(05)68005-2
- Kato A, 2003, NEPHROL DIAL TRANSPL, V18, P333, DOI 10.1093/ndt/18.2.333
- Katzmarzyk PT, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.15
- Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
- Kuk JL, 2006, OBESITY, V14, P336, DOI 10.1038/oby.2006.43
- Lee CG, 2011, J AM GERIATR SOC, V59, P233, DOI 10.1111/j.1532-5415.2010.03245.x
- Lee JSW, 2012, AGE, V34, P597, DOI 10.1007/s11357-011-9272-y
- Lopes JB, 2011, J CLIN DENSITOM, V14, P359, DOI 10.1016/j.jocd.2011.04.006
- Marinangeli CPF, 2013, NUTR REV, V71, P332, DOI 10.1111/nure.12025
- Mohammad A, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2016.38
- Narumi T, 2015, EUR J INTERN MED, V26, P118, DOI 10.1016/j.ejim.2015.01.008
- Navaneethan SD, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-108
- Neeland IJ, 2013, OBESITY, V21, pE439, DOI [10.1038/oby.20135, 10.1002/oby.20135]
- Newman AB, 2006, J GERONTOL A-BIOL, V61, P72, DOI 10.1093/gerona/61.1.72
- Newman AB, 2003, J AM GERIATR SOC, V51, P1602, DOI 10.1046/j.1532-5415.2003.51534.x
- Rolland Y, 2014, AM J CLIN NUTR, V100, P1352, DOI 10.3945/ajcn.114.086728
- Rothney MP, 2013, OBESITY, V21, pE134, DOI 10.1002/oby.20140
- Rubbieri G, 2014, CLIN CASES MINER BON, V11, P181, DOI 10.11138/ccmbm/2014.11.3.181
- Sanada K, 2010, EUR J APPL PHYSIOL, V110, P57, DOI 10.1007/s00421-010-1473-z
- Santilli V, 2014, CLIN CASES MINER BON, V11, P177, DOI 10.11138/ccmbm/2014.11.3.177
- Santos RR, 2013, REV MED MINAS GERAIS, V23, P64
- Shepherd JA, 2006, J CLIN DENSITOM, V9, P31, DOI 10.1016/j.jocd.2006.05.005
- Srikanthan P, 2016, AM J CARDIOL, V117, P1355, DOI 10.1016/j.amjcard.2016.01.033
- Studenski SA, 2014, J GERONTOL A-BIOL, V69, P547, DOI 10.1093/gerona/glu010
- Szulc P, 2010, AM J CLIN NUTR, V91, P1227, DOI 10.3945/ajcn.2009.28256
- Thibault R, 2012, ANN NUTR METAB, V60, P6, DOI 10.1159/000334879
- Toss F, 2012, AGE AGEING, V41, P677, DOI 10.1093/ageing/afs087
- World Health Organization, 2004, ICD 10 INT STAT CLAS
- Zamboni M, 2005, INT J OBESITY, V29, P1011, DOI 10.1038/sj.ijo.0803005
- Zamboni M, 1997, AM J CLIN NUTR, V66, P111